※一部利用できない機能があります
| 1.
図書 |
図書
|
永井竜児, 大島寛史編著 ; 青井啓悟 [ほか] 著
|
||||
| 2.
その他 |
その他
|
山本, 靖彦 ; Yamamoto, Yasuhiko
|
||||
| 3.
論文 |
論文
|
3. Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Yamamoto, Yasuhiko ; Liang, Mingkun ; Munesue, Seiichi ; Deguchi, Kisaburo ; Harashima, Ai ; Furuhara, Kazumi ; Yuhi, Teruko ; Zhong, Jing ; Akther, Shirin ; Goto, Hisanori ; Eguchi, Yuya ; Kitao, Yasuko ; Hori, Osamu ; Shiraishi, Yoshitake ; Ozaki, Noriyuki ; Shimizu, Yu ; Kamide, Tomoya ; Yoshikawa, Akifumi ; Hayashi, Yasuhiko ; Nakada, Mitsutoshi ; Lopatina, Olga ; Gerasimenko, Maria ; Komleva, Yulia ; Malinovskaya, Natalia ; Salmina, Alla B. ; Asano, Masahide ; Nishimori, Katsuhiko ; Shoelson, Steven E. ; Yamamoto, Hiroshi ; Higashida, Haruhiro ; 山本, 靖彦 ; 棟居, 聖一 ; 古原, 和美 ; 堀, 修 ; 白石, 昌武 ; 尾﨑, 紀之 ; 吉川, 陽文 ; 中田, 光俊 ; 東田, 陽博
概要:
金沢大学医薬保健研究域医学系<br />Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bo
…
nding behaviours. Mice lacking secreted oxcytocin (Oxt -/-, Cd38 -/-) or its receptor (Oxtr -/-) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt -/- and Cd38 -/-, but not Oxtr -/- mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The increases in oxcytocin in the brain which follow exogenous administration are lost in Ager -/- male mice lacking RAGE, and behaviours characteristic to abnormalities in oxcytocin signalling are recapitulated in Ager -/- mice, including deficits in maternal bonding and hyperactivity. Our findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding.<br />30820471
続きを見る
|
||||
| 4.
論文 |
論文
|
Higuchi, Takashi ; Takeuchi, Akihiko ; Munesue, Seiichi ; Yamamoto, Norio ; Hayashi, Katsuhiro ; Kimura, Hiroaki ; Miwa, Shinji ; Inaki, Hiroyuki ; Shimozaki, Shingo ; Kato, Takashi ; Aoki, Yu ; Abe, Kensaku ; Taniguchi, Yuta ; Aiba, Hisaki ; Murakami, Hideki ; Harashima, Ai ; Yamamoto, Yasuhiko ; Tsuchiya, Hiroyuki ; 武内 , 章彦 ; 棟居, 聖一 ; 山本, 憲男 ; 林 , 克洋 ; 三輪, 真嗣 ; 谷口, 裕太 ; 原島, 愛 ; 山本, 靖彦 ; 土屋, 弘行
概要:
金沢大学医薬保健研究域医学系<br />Surgical resection is the only treatment for chondrosarcomas, because of their resistance to chemoth
…
erapy and radiotherapy; therefore, additional strategies are crucial to treat chondrosarcomas. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor, which has been reported as a possible therapeutic target in certain malignancies including chondrosarcomas. In this study, we demonstrated that a nonsteroidal anti-inflammatory drug, zaltoprofen, could induce PPARγ activation and elicit anti-tumor effects in chondrosarcoma cells. Zaltoprofen was found to induce expressions of PPARγ mRNA and protein in human chondrosarcoma SW1353 and OUMS27 cells, and induce PPARγ-responsible promoter reporter activities. Inhibitory effects of zaltoprofen were observed on cell viability, proliferation, migration, and invasion, and the activity of matrix metalloproteinase-2 (MMP2); these effects were dependent on PPARγ activation and evidenced by silencing PPARγ. Moreover, we showed a case of a patient with cervical chondrosarcoma (grade 2), who was treated with zaltoprofen and has been free from disease progression for more than 2 years. Histopathological findings revealed enhanced expression of PPARγ and reduced expression of MMP2 after administration of zaltoprofen. These findings demonstrate that zaltoprofen could be a promising drug against the malignant phenotypes in chondrosarcomas via activation of PPARγ and inhibition of MMP2 activity. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.<br />29573200
続きを見る
|
||||
| 5.
論文 |
論文
|
El‑Far, Ali Hafez Ali MohammedTsuchiya Hiroshi Yamamoto Hazem M.E. Shaheen Yasser S. El‑Sayed Shuhei Kawano Sei‑Ichi Tanuma Yasuhiko Yamamoto ; Munesue, Seiichi ; Harashima, Ai ; Satoh, Akira ; Shindo, Mika ; Nakajima, Shingo ; Inada, Mana ; Tanaka, Mariko ; Takeuchi, Akihiko ; Tsuchiya, Hiroyuki ; Yamamoto, Hiroshi ; Shaheen, Hazem M.E. ; El‑Sayed, Yasser S. ; Kawano, Shuhei ; Tanuma, Sei‑Ichi ; Yamamoto, Yasuhiko ; 棟居, 聖一 ; 原島, 愛 ; 武内 , 章彦 ; 土屋, 弘行 ; 山本, 靖彦
概要:
金沢大学医薬保健研究域医学系<br />Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in
…
the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized‑peptide strategy drug design system. Papaverine significantly inhibited RAGE‑dependent nuclear factor κ‑B activation driven by high mobility group box‑1, a RAGE ligand. Using RAGE‑ or dominant‑negative RAGE‑expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE‑dependent cell proliferation and migration dose‑dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies.<br />Embargo Period 6 months
続きを見る
|
||||
| 6.
論文 |
論文
|
山本, 靖彦 ; Yamamoto, Yasuhiko
|
||||
| 7.
その他 |
その他
|
山本, 靖彦 ; Yamamoto, Yasuhiko
概要:
取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1211号, 学位授与年月日：平成8年3月25日,学位授与年：1996
|
||||
| 8.
論文 |
論文
|
山本, 博 ; 山本, 靖彦
概要:
学会開催報告 / Reviews
|
||||
| 9.
論文 |
論文
|
山本, 靖彦
概要:
金沢大学 医 第1内科<br />糖尿病状態で促進的に形成される後期糖化反応生成物(AGE)が培養膵癌細胞の増殖にどのように影響するかを検討した. 1)培養膵癌細胞Mia PaCa-2細胞の増殖はAGEの濃度に依存して促進された. 2)AG
…
EはMia PaCa-2細胞のPDGF-B mRNAレベルを増大させ,抗ヒトPDGF-BB抗体はAGEによるMia PaCa-2細胞のDNA合成をほぼ完全に抑制した. 3)RAGE mRNAに対するアンチセンスオリゴヌクレオチド投与により,AGEのMia PaCa-2細胞のDNA合成促進及びPDGF-B遺伝子発現誘導効果はほぼ完全に抑制された.以上の結果より,AGEは培養膵癌細胞Mia PaCa-2細胞の増殖を誘導し,この増殖誘導にはPAGEを介するオートクリンPDGF-Bの産生亢進を介するものと結論された
続きを見る
|
||||
| 10.
論文 |
論文
|
山本, 靖彦
|
