1.

論文

論文
Tsuchida, Masayuki ; Kawashiri, Masa-aki ; Teramoto, Ryota ; Takata, Mutsuko ; Sakata, Kenji ; Omi, Wataru ; Okajima, Masaki ; Takamura, Masayuki ; Ino, Hidekazu ; Kita, Yoshihito ; Takegoshi, Tadayoshi ; Inaba, Hideo ; Yamagishi, Masakazu ; 川尻, 剛照 ; 寺本, 了太 ; 坂田, 憲治 ; 岡島, 正樹 ; 高村, 雅之 ; 井野, 秀一 ; 稲葉, 英夫 ; 山岸, 正和
出版情報: Circulation journal.  73  pp.1243-1247,  2009-06-25.  Japanese Circulation Society = 日本循環器学会
URL: http://hdl.handle.net/2297/48501
概要: Background: Although acute coronary syndrome (ACS) and stroke are known to increase after earthquake, few data exist reg arding the effect of earthquake on these cardiovascular events in rural areas. Methods and Results: The Noto Peninsula earthquake with a magnitude of 6.9 occurred at 9:45 a.m. on 25 March 2007. The first case of ACS occurred approximately 15 min later, whereas cerebral hemorrhage (CH) occurred 72 h after the onset of earthquake. During the 35 days after earthquake, among 49 patients who were attended by local ambulance, 5 patients with ACS (10.2%) and 8 with CH (16.3%) were documented and 4 died. The total number of both ACS and CH cases was greater than the averages for the same period of the past 3 years in this area (2.0 vs 5 and 2.3 vs 8, P<0.01). Interestingly, the most cases of ACS had occurred within 7 days after earthquake and for CH not until 35 days later. Conclusions: Even in rural areas a severe earthquake results in increased incidence of ACS and CH, which can occur at different times after the event, although the effects of other environmental factors should be further investigated. (Circ J 2009; 73: 1243-1247)<br />出版者照会後に全文公開 続きを見る
2.

その他

その他
金森, 尚美 ; 古荘, 浩司 ; 松尾, 信郎 ; 草山, 隆志 ; 近田, 明男 ; 北野, 鉄平 ; 小林, 大祐 ; 薄井, 荘一郎 ; 村井, 久純 ; 中嶋, 憲一 ; 高村, 雅之
出版情報: 北陸循環器核医学研究会記録集.  59  pp.1-17,  2013-02-02.  北陸循環器核医学研究会 = Hokuriku Nuclear Medicine Circulation Conference
URL: http://hdl.handle.net/2297/34722
3.

論文

論文
大倉, 誓一郎 ; 高村, 雅之 ; 油谷, 伊佐央 ; 三田村, 康仁 ; 村井, 久純 ; 古荘, 浩司 ; 丸山, 美知郎 ; 阪上, 学 ; 金子, 周一 ; 高田, 重男
出版情報: 北陸循環器核医学研究会記録集.  43  pp.15-16,  2005-01-22.  北陸循環器核医学研究会 = Hokuriku Nuclear Medicine Circulation Conference
URL: http://hdl.handle.net/2297/25470
4.

論文

論文
吉澤, 尚 ; 湯浅, 豊司 ; 高村, 雅之 ; 長井, 英夫 ; 阪上, 学 ; 小林, 健一 ; 高田, 重男
出版情報: 北陸循環器核医学研究会記録集.  30  pp.21-22,  1998-07-04.  北陸循環器核医学研究会 = Hokuriku Nuclear Medicine Circulation Conference
URL: http://hdl.handle.net/2297/25705
5.

論文

論文
安間, 圭一 ; 森田, 裕子 ; 古荘, 浩司 ; 丸山, 美知郎 ; 佐伯, 隆広 ; 高村, 雅之 ; 湯浅, 豊司 ; 長井, 英夫 ; 勝木, 達夫 ; 阪上, 学 ; 小林, 健一 ; 高田, 重男 ; 臼田, 和生
出版情報: 北陸循環器核医学研究会記録集.  28  pp.21-22,  1997-07-12.  北陸循環器核医学研究会 = Hokuriku Nuclear Medicine Circulation Conference
URL: http://hdl.handle.net/2297/25996
6.

論文

論文
吉澤, 尚 ; 佐伯, 隆広 ; 丸山, 美知郎 ; 高村, 雅之 ; 居軒, 功 ; 湯浅, 豊司 ; 長井, 英夫 ; 織田, 裕之 ; 島倉, 淳泰 ; 阪上, 学 ; 小林, 健一 ; 高田, 重男
出版情報: 北陸循環器核医学研究会記録集.  27  pp.17-18,  1996-12-07.  北陸循環器核医学研究会 = Hokuriku Nuclear Medicine Circulation Conference
URL: http://hdl.handle.net/2297/26161
7.

論文

論文
Nasti, Alessandro ; Sakai, Yoshio ; Seki, Akihiro ; Buffa, Geraldine Belen ; Komura, Takuya ; Mochida, Hatsune ; Yamato, Masatoshi ; Yoshida, Keiko ; Ho, Tuyen T. B. ; Takamura, Masayuki ; Usui, Soichiro ; Wada, Takashi ; Honda, Masao ; Kaneko, Shuichi ; 酒井, 佳夫 ; 餅田, 初音 ; 吉田, 佳子 ; 高村, 雅之 ; 薄井, 荘一郎 ; 和田, 隆志 ; 本多, 政夫 ; 金子, 周一
出版情報: European Journal of Immunology.  47  pp.2163-2174,  2017-12.  Wiley
URL: http://hdl.handle.net/2297/00050487
概要: 金沢大学医薬保健研究域医学系<br />Stromal cells in adipose tissue are useful for repair/regenerative therapy as they harbor a su bstantial number of mesenchymal stem cells; therefore, freshly isolated autologous uncultured adipose tissue derived stromal cells (u-ADSCs) are useful for regenerative therapy, and obviate the need for mesenchymal stem cells. We evaluated the therapeutic effect of murine u-ADSCs and sorted subsets of u-ADSCs in a concanavalin A (ConA) induced murine model of hepatitis, as well as their characteristics. We found that 10–20% of u-ADSCs expressed the CD45 leukocyte-related antigen. CD68, which is a marker of macrophages (MΦs), was expressed by 50% of CD45+ u-ADSCs. About 90% of CD68+CD45+ cells expressed CD206 antigen, which is a marker of inhibitory M2-type MΦs. Genes related to M2-type MUs were especially more highly expressed by CD45+CD206+ u-ADSCs than by CD45− u-ADSCs. CD45+ u-ADSCs inhibited the expression of cytokines/chemokines and suppressed the proliferation of splenocytes stimulated with ConA. We observed that not only whole u-ADSCs, but also the CD45+ subset of u-ADSCs ameliorated the ConA-induced hepatitis in mice. In conclusion, we show that freshly isolated murine u-ADSCs were effective against acute hepatitis, and CD45+ u-ADSCs acting phenotypically and functionally like M2-type MΦs, contributed to the repair of liver tissue undergoing inflammation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim<br />Embargo Period 12 months 続きを見る
8.

論文

論文
Nakahashi, Takuya ; Tada, Hayato ; Sakata, Kenji ; Nomura, Akihiro ; Ohira, Miho ; Mori, Mika ; Takamura, Masayuki ; Hayashi, Kenshi ; Yamagishi, Masakazu ; Kawashiri, Masa-aki ; 多田, 隼人 ; 坂田, 憲治 ; 野村, 章洋 ; 大平, 美穂 ; 森, 三佳 ; 高村, 雅之 ; 林, 研至 ; 山岸, 正和 ; 川尻, 剛照
出版情報: Journal of Atherosclerosis and Thrombosis.  25  pp.709-719,  2018.  日本動脈硬化学会 = Japan Atherosclerosis Society
URL: http://hdl.handle.net/2297/00053009
概要: 金沢大学附属病院循環器内科<br />Aim: To assess whether combining measurements obtained from carotid ultrasonography in addition to the age, creatinine, and ejection fraction (ACEF) score would improve the predictive ability of outcome in patients with acute coronary syndrome (ACS).\nMethods: We examined 264 patients with ACS (194 men; mean age: 68±11 years) who underwent percutaneous coronary intervention. The carotid plaque score (cPS) and intima–media thickness (cIMT) were determined by carotid ultrasonography. The modified ACEF score was calculated using the following formula: (age/left ventricular ejection fraction) +1 point for every 10 mL/min reduction in creatinine clearance below 60 mL/min per 1.73 m2. The endpoint of this study was major adverse cardiovascular and cerebrovascular events (MACEs), defined as all-cause death, myocardial infarction, stoke, and target vessel revascularization.\nResults: During the median 4-year follow-up, there were 121 incidents of MACEs. Multivariate Cox proportional hazard regression analysis revealed that cPS ≥9.8 (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.01–2.31) and ACEF score ≥1.20 (HR, 1.62; 95% CI, 1.11–2.39) were significantly associated with MACEs, whereas cIMT was not. When the new combined risk score was calculated by multiplying the cPS by the modified ACEF score, the freedom from MACEs at 5 years was 71% and 31% for the lower and higher scores, respectively (p<0.001). The area under the receiver-operating characteristic curve for MACEs for the ACEF score, cPS, and combined risk score were 0.65, 0.66, and 0.71, respectively (p<0.05).\nConclusion: The cPS offers an incremental predictive value when combined to the simple ACEF score in ACS.<br />This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. 続きを見る
9.

論文

論文
篁, 俊成 ; 和田, 隆志 ; 酒井, 明人 ; 水腰, 英四郎 ; 高村, 雅之 ; 古市, 賢吾 ; 古荘, 浩司 ; 御簾, 博文 ; 金子, 周一
出版情報: 金沢大学資料館紀要 = Bulletin of The Kanazawa University Musium.  7  pp.15-39,  2012-03-01.  金沢大学資料館 = Kanazawa University Musium
URL: http://hdl.handle.net/2297/30405
10.

論文

論文
高村, 雅之 ; Takamura, Masayuki
出版情報: 平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 = 2015 Fiscal Year Final Research Report.  2013-04-01 - 2016-03-31  pp.4p.-,  2016-05-09. 
URL: http://hdl.handle.net/2297/00051545
概要: 金沢大学附属病院循環器内科<br />臨床研究(自己脂肪組織由来間質細胞を用いた再生医療に関する臨書研究~虚血性心不全に対して~)実施した際の臨床サンプルを用いて、再生細胞の特性解析、抗サイトカイン効果の解析を実施進めた。マウス モデルを用いた検討では、虚血再灌流障害モデルマウスに対して、脂肪組織由来再生細胞投与による心機能改善効果とその機序について解析を進めた。再生細胞投与による炎症性サイトカインの上昇抑制効果とそのシグナルについても解析を進めた。上記の結果の一部を、第80回日本循環器学会総会と第15回日本再生医療学会総会において発表した。<br />The analysis of adipose tissue derived regenerative cell were performed in patients who underwent our clinical study entitled “The Effect of Autologous Adipose Tissue Derived Regenerative Cells to Ischemic Heart Failure Patient”. Part of the beneficial effects to improve the cardiac performance may be related with reduction of inflammatory cytokines such as IL-1B, TNF-A.Also we investigated the effect of adipose tissue derived regenerative cells to myocardial ischemia-reperfusion model mice. And the significant reduction of inflammatory cytokines and improved cardiac function were closely related with the infusion of regenerative cells.Part of these findings were presented at The 80th Annual Scientific Meeting of Japanese Circulation Society and The 15th Congress of The Japanese Society for Regenerative Medicine.<br />研究課題/領域番号:25461049, 研究期間(年度):2013-04-01 - 2016-03-31 続きを見る