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Sakai, Kenji ; Asakawa, Miwako ; Takahashi, Ryoichi ; Ishida, Chiho ; Nakamura, Ritsuko ; Hamaguchi, Tsuyoshi ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito ; 坂井, 健二 ; 中村, 律子 ; 濵口, 毅 ; 小野, 賢二郎 ; 岩佐, 和夫 ; 山田, 正仁
概要:
金沢大学附属病院神経内科<br />Embargo Period 12 months
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Hamaguchi, Tsuyoshi ; Noguchi-Shinohara, Moeko ; Nozaki, Ichiro ; Nakamura, Yosikazu ; Sato, Takeshi ; Kitamoto, Tetsuyuki ; Mizusawa, Hidehiro ; Yamada, Masahito
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金沢大学医薬保健研究域医学系<br />To elucidate the association between medical procedures and sporadic Creutzfeldt-Jakob disease (sCJD
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), we analyzed medical procedures (any surgical procedure, neu- rosurgery, ophthalmic surgery, and blood transfusion) for patients registered by the CJD Surveillance Committee in Japan during 1999-2008. We conducted an age-stratified case-control study with 753 sCJD patients and 210 controls and a study of patients who underwent neurosurgical or ophthalmic surgical procedures at the same hospital. Although the control group was relatively small, no evidence was found that prion disease was transmitted through the investigated medical procedures before onset of sCJD. After onset of sCJD, 4.5% of the sCJD patients underwent operations, including neurosurgical for 0.8% and ophthalmic for 1.9%; no special precautions against transmission of prion diseases were taken. Fortunately, we have not identified patients with prion disease attributed to these operations. Our findings indicate that surgical procedures or blood transfusion had little effect on the incidence of sCJD.
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Noguchi-Shinohara, Moeko ; Hamaguchi, Tsuyoshi ; Nozaki, Ichiro ; Sakai, Kenji ; Yamada, Masahito
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Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfel
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dt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n = 12), AD (n = 10) and RPD but no CJD (non-CJD-RPD; n = 9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n = 10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this. © 2011 Springer-Verlag.
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Sakai, Kenji ; Hamaguchi, Tsuyoshi ; Yamada, Masahito
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金沢大学医薬保健研究域医学系<br />A 77-year-old man showed bilateral abducens palsies and multiple cranial nerve enhancement on magnet
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ic resonance images (MRI) and aseptic meningitis. He had xerophthalmia and xerostomia. Serum anti-SS-A and anti-SS-B antibodies were present. He had Sjogren's syndrome (SjS) and corticosteroid therapy ameliorated the symptoms. The cranial nerve enhancement and the cerebrospinal fluid findings were normalized. In patients with SjS, there have not been any reports of multiple areas of cranial nerve enhancement on MRI. We propose that in this case the aseptic meningitis and subsequent lymphocytic infiltration to the cranial nerves contributed to the multiple cranial neuropathy and multiple cranial nerve enhancement on MRI. © 2010 The Japanese Society of Internal Medicine.
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濱口, 毅 ; Hamaguchi, Tsuyoshi
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金沢大学附属病院<br />赤ワインポリフェノールのアルツハイマー病(AD)に対する効果を検討するため、ADモデルマウスに赤ワインポリフェノールの1 種であるケルセチンを経口投与した。ケルセチン投与によって、AD モデルマウスの体重は増加し
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たが、生存率、運動機能、認知機能、脳病理でのAD 変化に有意な差を認めず、ケルセチン経口投与によるAD 治療は難しいものと考えられた。<br />研究課題/領域番号:19890083, 研究期間(年度):2007 – 2008<br />出典：「アルツハイマー病に対するワイン関連ポリフェノールの治療効果の検討」研究成果報告書 課題番号19890083（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19890083/19890083seika/)を加工して作成
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濱口, 毅 ; Hamaguchi, Tsuyoshi
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金沢大学附属病院<br />本研究は、試験管内でアミロイドbの線維化を促進することを確認しているカゼイン、フィブロイン、セリシン、アクチンなどの食品あるいは化粧品由来のペプチドが、生体内でもアミロイドbの線維化を促進するかを検討することを目
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的としている。試験管内で線維化したカゼイン、アクチンの線維をモデルマウスの脳および腹腔内に接種し、接種1年後に解剖して脳へのアミロイドbの沈着程度を検討した。カゼイン線維を脳内に接種したマウスの一部では、脳血管にアミロイドbの沈着を認めた。<br />We reported that casein, fibroin, siren, and actin, which are contained in foods or cosmetics, could promote amyloid b protein fibril formation in vitro. The objective of this study is to investigate whether the fibrils of these peptides can promote cerebral b-amyloidosis in vivo. We made the fibrils of casein and actin in vitro, and injected them into Alzheimer's disease (AD) model mouse brain. Furthermore, intraperitoneal injection was also performed. One year after the injections, we evaluated amyloid b protein (Ab) deposition in the mice brain. We found a little Ab deposition on the blood vessels in AD model mice injected casein into the brain. We will continue to evaluate Ab deposition of the mice brains.<br />研究課題/領域番号:26461267, 研究期間(年度):2014-04-01 – 2017-03-31
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濵口, 毅 ; Hamaguchi, Tsuyoshi
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金沢大学附属病院脳神経内科<br />高齢者ブレインバンクから33例の剖検症例の硬膜を収集し、それらの硬膜をアミロイドbeta蛋白質（Abeta）に対する抗体（4G8）を用いて免疫染色を行なったところ、8例（24.2%）で硬膜上の血管にAb
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etaの沈着を認めた。収集した硬膜をホモジネートし、若年（3ヶ月齢）のAlzheimer病（AD）モデルマウスの脳に接種したところ、接種12ヶ月後にはAbeta沈着を認めた硬膜を接種したADモデルマウスでは脳血管にAbetaの沈着（脳アミロイドアンギオパチー：CAA）を認めたが、Abetaが沈着していなかった硬膜を接種したADモデルマウスでは脳実質および脳血管共にAbetaの沈着を認めなかった。<br />We obtained dura maters from 33 autopsied patients from a geriatric brain bank, and immunohistochemical study of those dura maters were performed using an antibody against amyloid beta protein (Abeta). Eight of 33 patients (24.2%) had Abeta deposition on the vessel of the dura mater. The dura maters were homogenized at 19% (w/v) in PBS, and the supernatants were injected into the brain of Alzheimer’s disease (AD) model mice. One year after the injection, immunohistochemical study using the antibody against Abeta showed that Abeta deposited on the vessels of AD model mice brain injected the homogenate of dura mater with Abeta deposition, while no Abeta deposition was observed in the brain and vessels of AD model mice injected the homogenate of dura mater without Abeta deposition.<br />研究課題/領域番号:17K09752, 研究期間(年度):2017-04-01 - 2020-03-31<br />出典：「モデルマウスを用いた硬膜移植による脳βアミロイドーシスの個体間伝播についての研究」研究成果報告書 課題番号17K09752（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09752/17K09752seika/)を加工して作成
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