1.

論文

論文
Motozaki, Yuko ; Sugiyama, Yu ; Ishida, Chiho ; Komai, Kiyonobu ; Matsubara, Shiro ; Yamada, Masahito
出版情報: Journal of the Neurological Sciences.  260  pp.236-239,  2007-09-15.  Elsevier
URL: http://hdl.handle.net/2297/7021
概要: 金沢大学医学部附属病院神経内科<br />A family with familial amyloid polyneuropathy (FAP) due to a transthyretin (TTR) Leu58Arg mut ation was investigated clinicopathologically. The proband presented with sensorimotor-autonomic polyneuropathy and autopsy demonstrated massive amyloid deposition in the peripheral nerves and heart. However, the mother was characterized by carpal tunnel syndrome and ocular vitreous opacities. Thus, there was considerable phenotypic heterogeneity among family members despite the identical TTR genotype. © 2007 Elsevier B.V. All rights reserved. 続きを見る
2.

論文

論文
Hirohata, Mie ; Yasukawa, Yoshihiro ; Ishida, Chiho ; Komai, Kiyonobu ; Yamada, Masahito
出版情報: Journal of the Neurological Sciences.  232  pp.111-113,  2005-05-15.  Elsevier
URL: http://hdl.handle.net/2297/7404
概要: 金沢大学医学部附属病院放射線部<br />We report a 50-year-old woman with primary Sjögren's syndrome (SjS) who initially showe d forgetfulness, and later developed disturbance of consciousness. In addition to aseptic meningoencephalitis revealed by cerebrospinal fluid examination and magnetic resonance imaging (MRI), the presence of serum anti-SS-A and anti-SS-B antibodies and inflammatory findings in lip biopsy indicated primary SjS. Fluid attenuated inversion recovery (FLAIR) of MRI revealed well defined small, high signal intensity areas in the cortex involving the subcortical white matter. Corticosteroid therapy resulted in rapid and nearly complete resolution of the cortical lesions with marked improvement of the clinical manifestations. Memory disturbance is a rare initial manifestation in meningoencephalitis associated with SjS. Our patient with SjS showed inflammatory cortical lesions on MRI, which were reversed by corticosteroid therapy. © 2005 Elsevier B.V. All rights reserved. 続きを見る
3.

論文

論文
Sakai, Kenji ; Ikeda, Yoshihisa ; Ishida, Chiho ; Matsumoto, Yasuko ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito
出版情報: Neuromuscular Disorders.  25  pp.706-712,  2015-09-01.  Elsevier
URL: http://hdl.handle.net/2297/43019
概要: Inclusion body myositis is a form of inflammatory myopathy. We identified 4 cases of inclusion body myositis showing granuloma formation in muscle tissue and aimed to assess the features of this atypical form of inclusion body myositis. We retrospectively reviewed consecutive patients who satisfied European Neuromuscular Centre IBM Research Diagnostic Criteria 2011. Then, we assessed clinical profiles and pathological findings in patients with inclusion body myositis with granuloma and compared these findings with those of typical inclusion body myositis without granuloma. We identified 15 patients with inclusion body myositis. Four patients showed granuloma formation in muscle tissue in addition to typical pathological features of inclusion body myositis. Granulomas comprised a mixture of inflammatory cells, such as macrophages, epithelioid histiocytic cells, and lymphocytes. One patient was found to have mediastinal granulomatous lymphadenopathy; however, the evidence in other patients was insufficient for a diagnosis of systemic sarcoidosis. There were no significant differences between groups with and without granuloma regarding clinical manifestations, laboratory findings, response to immunomodulating therapies, or myopathological profiles. We established a new form of inclusion body myositis showing granuloma formation in muscle tissue. Inclusion body myositis and granuloma formation could have identical pathomechanisms concerning dysregulation of autophagy. © 2015 Elsevier B.V.<br />in Press / Embargo Period 12 months 続きを見る
4.

論文

論文
Sakai, Kenji ; Ishida, Chiho ; Morinaga, Akiyoshi ; Takahashi, Kazuya ; Yamada, Masahito
出版情報: Cerebellum.  14  pp.707-710,  2015-05-12.  Springer
URL: http://hdl.handle.net/2297/43020
概要: We described a 63-year-old Japanese female with genetically confirmed Huntington’s disease who showed unusual pathological findings in the cerebellum. This case exhibited typical neuropathological features as Huntington’s disease, including severe degeneration of the neostriatum and widespread occurrence of ubiquitin and expanded polyglutamine-positive neuronal intranuclear and intracytoplasmic inclusions. The cerebellum was macroscopically unremarkable; however, somatic sprouts and halo-like amorphous materials of Purkinje cell with a large amount of torpedoes were noteworthy. Furthermore, the Purkinje cells were found to have granular cytoplasmic inclusions. Somatic sprouting is a form of degenerated Purkinje cell exhibited in several specific conditions. Although this finding usually appeared in developmental brains, several neurodegenerative disorders, including Menkes kinky hair disease, familial spinocerebellar ataxia, acute encephalopathy linked to familial hemiplegic migraine, and several other conditions, have been reported showing sprouting from the soma of Purkinje cell. We propose that Huntington’s disease is another degenerative condition associated with these distinct neuropathological findings of Purkinje cell. Abnormally accumulated huntingtin protein in the cytoplasm could be related to the development of these structures. © 2015 Springer Science+Business Media New York<br />In Press 続きを見る
5.

論文

論文
Sakai, Kenji ; Ikeda, Yoshihisa ; Ishida, Chiho ; Matsumoto, Yasuko ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito
出版情報: Neuromuscular Disorders.  25  pp.706-712,  2015-09-01.  Elsevier B.V.
URL: http://hdl.handle.net/2297/43403
概要: Inclusion body myositis is a form of inflammatory myopathy. We identified 4 cases of inclusion body myositis showing granuloma formation in muscle tissue and aimed to assess the features of this atypical form of inclusion body myositis. We retrospectively reviewed consecutive patients who satisfied European Neuromuscular Centre IBM Research Diagnostic Criteria 2011. Then, we assessed clinical profiles and pathological findings in patients with inclusion body myositis with granuloma and compared these findings with those of typical inclusion body myositis without granuloma. We identified 15 patients with inclusion body myositis. Four patients showed granuloma formation in muscle tissue in addition to typical pathological features of inclusion body myositis. Granulomas comprised a mixture of inflammatory cells, such as macrophages, epithelioid histiocytic cells, and lymphocytes. One patient was found to have mediastinal granulomatous lymphadenopathy; however, the evidence in other patients was insufficient for a diagnosis of systemic sarcoidosis. There were no significant differences between groups with and without granuloma regarding clinical manifestations, laboratory findings, response to immunomodulating therapies, or myopathological profiles. We established a new form of inclusion body myositis showing granuloma formation in muscle tissue. Inclusion body myositis and granuloma formation could have identical pathomechanisms concerning dysregulation of autophagy. © 2015 Elsevier B.V.<br />Embargo Period (12 months) 続きを見る
6.

論文

論文
Ikeda, Tokuhei ; Noto, Daisuke ; Noguchi-Shinohara, Moeko ; Ono, Kenjiro ; Takahashi, Kazuya ; Ishida, Chiho ; Yoshita, Mitsuhiro ; Kawaguchi, Masahito ; Kawahara, Norio ; Iwasa, Kazuo ; Tomita, Katsuro ; Yamada, Masahito
出版情報: Clinical Neurology and Neurosurgery.  112  pp.62-64,  2010-01-01.  Elsevier BV
URL: http://hdl.handle.net/2297/19435
概要: 金沢大学附属病院神経内科<br />We report two cases of superficial siderosis (SS) of the central nervous system (CNS), which is caused by chronic haemorrhaging into the subarachnoid space with haemosiderin deposition in the superficial portion of the CNS. Patient 1 had fluid collection in the spinal canal, which was reported as the source of the chronic bleeding. Patient 2 was bleeding from thickened dura at the level of the sacral vertebrae. Both of the patients had xanthochromic cerebrospinal fluid. We surgically repaired the sources of bleeding. Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms were not aggravated for about 1 year. We measured several CSF markers of SS before and after surgery. Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-tau), iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly elevated at diagnosis. After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly reduced while CSF-iron and CSF-ferritin had not decreased. It is suggested that CSF-t-tau and CSF-p-tau reflected the neural damage in SS and were useful to evaluate the effectiveness of SS therapies. © 2009 Elsevier B.V. All rights reserved. 続きを見る
7.

その他

その他
石田, 千穂 ; Ishida, Chiho
出版情報: 博士学位論文要旨 論文内容の要旨および論文審査結果の要旨/金沢大学大学院医学研究科.  平成11年7月  1999-07-01.  金沢大学
URL: http://hdl.handle.net/2297/15498
概要: 取得学位 : 博士(医学), 学位授与番号 : 医博乙第1475号,学位授与年月日:平成11年2月17日,学位授与年:1999
8.

論文

論文
Ishida, Chiho ; Furui, Eisuke ; Sakashita, Yasuo ; Yamada, Masahito
出版情報: Internal Medicine.  44  pp.326-327,  2005-01-01.  The Japanese Society of Internal Medicine = 日本内科学会
URL: http://hdl.handle.net/2297/24034
概要: 金沢大学医薬保健研究域医学系<br />We report a case of a 53-year-old man with Behçet’s disease (BD) and paradoxical stroke. This patient suddenly developed sensory aphasia, right oculomotor palsy, nystagmus, and left ataxic hemiparesis. MR images showed fresh embolic infarcts in the midbrain and the left parietotemporal lobe. He presented with uveitis, oral aphthous ulcers and genital ulcers. An electrocardiogram revealed no abnormalities, and a transesophageal echocardiogram disclosed a patent foramen ovale. Since venous involvement is common in BD, we suspected the presence of smaller thrombi probable in this patient. We conclude that embolic stroke is a notable complication of BD with right-to-left shunting. 続きを見る
9.

論文

論文
Kato-Motozaki, Yuko ; Koma, Kiyonobu ; Takahashi, Kazuya ; Ishida, Chiho ; Ueda, Masami ; Kusunoki, Susumu ; Yamada, Masahito
出版情報: Internal Medicine.  48  pp.569-572,  2009-01-01.  The Japanese Society of Internal Medicine = 日本内科学会
URL: http://hdl.handle.net/2297/24207
概要: 金沢大学医薬保健研究域医学系<br />Polyethylene glycol-interferon ホア (PEG-IFNホア) has been used as the standard treatment for hepa titis C virus (HCV) infection. There have been no previous reports of polyradiculoneuropathy with anti-ganglioside antibodies induced by PEG-IFNホア-2b. We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN ホア-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in his symptoms accompanied by a reduction in the antibody level. PEG-IFN ホア-2b may induce peripheral neuropathy mediated by anti-GA1 and anti-GM1 antibodies. © 2009 The Japanese Society of Internal Medicine. 続きを見る
10.

論文

論文
Ishida, Chiho ; Fujii, Eisuke ; Sakashita, Yasuo ; Yamada, Masahito
出版情報: Internal Medicine.  44  pp.326-327,  2005-04-01.  日本内科学会 = the Japanese Society of Internal Medicine
URL: http://hdl.handle.net/2297/29265
概要: We report a case of a 53-year-old man with Behçet's disease (BD) and paradoxical stroke. This patient suddenly developed sensory aphasia, right oculomotor palsy, nystagmus, and left ataxic hemiparesis. MR images showed fresh embolic infarcts in the midbrain and the left parietotemporal lobe. He presented with uveitis, oral aphthous ulcers and genital ulcers. An electrocardiogram revealed no abnormalities, and a transesophageal echocardiogram disclosed a patent foramen ovale. Since venous involvement is common in BD, we suspected the presence of smaller thrombi probable in this patient. We conclude that embolic stroke is a notable complication of BD with right-to-left shunting. 続きを見る