1.

論文

論文
Hayashi, Yasuhiko ; Shima, Hiroshi ; Kinoshita, Masashi ; Nakada, Mitsutoshi ; Miyashita, Katsuyoshi ; Hamada, Jun-ichiro
出版情報: Journal of Clinical Neuroscience.  16  pp.1075-1077,  2009-08-01.  Elsevier
URL: http://hdl.handle.net/2297/18381
概要: 金沢大学附属病院脳神経外科<br />A 30-year-old man presented with a history of several convulsive episodes. A CT scan showed a calcifi ed focus in the right temporal lobe. Cerebral angiography yielded no abnormal findings. At craniotomy, the M3 portion of the middle cerebral artery was found to terminate with a blind end at the junction with the calcified mass. A pathological diagnosis of an ossified cerebral aneurysm was made. Calcified cerebral aneurysms are not rare; they are thought to be the result of intra-aneurysmal thrombosis or degenerative changes in the aneurysmal wall. However, complete mural ossification of a cerebral aneurysm is seldom seen, and ossified peripheral middle cerebral artery aneurysms are extremely rare in young individuals. The ossified aneurysm that we report developed over a prolonged period and may have arisen during childhood. © 2008 Elsevier Ltd. All rights reserved.. 続きを見る
2.

論文

論文
Kinoshita, Masashi ; Nakada, Mitsutoshi ; Tanaka, Shingo ; Ozaki, Noriyuki ; Hamada, Jun-ichiro ; Hayashi, Yutaka
出版情報: Acta Neurochirurgica.  153  pp.659-665,  2011-03-01.  Springer Verlag (Germany)
URL: http://hdl.handle.net/2297/26239
概要: 金沢大学医薬保健研究域医学系<br />Background: The retrochiasmatic region is one of the most challenging areas to surgically expose. Th e authors evaluated the transcrusal approach, which involves removal of the superior and posterior semicircular canal from the ampulla to the common crus, to expose the retrochiasmatic region and compared it with the retrolabyrinthine approach, both of which are a variation of the posterior petrosal approach with hearing preservation, with a special emphasis on the influence of temporal lobe retraction. Methods: Six sides of silicone-injected cadaveric heads were dissected using two approaches: the transcrusal approach and the retrolabyrinthine approach. For each craniotomy, 3 exposure parameters in the retrochiasmatic region were measured: (1) horizontal distance, (2) vertical distance, and (3) triangular area of exposure, at three different levels of temporal lobe retractions: 0, 5, and 10 mm of retraction from the level of the tentorial incisura. Results: Without temporal lobe retraction, only the transcrusal and not the retrolabyrinthine approach provided a direct exposure of the retrochiasmatic region, especially in the horizontal distance (p < 0.001). At all levels of temporal lobe retraction, the transcrusal approach provided greater exposure in the horizontal and vertical distances and in the area of exposure. Nonetheless, in the horizontal distance, the difference between the transcrusal and retrolabyrinthine approaches decreased along with increased temporal lobe retraction, and almost no difference was obtained at 10 mm of retraction. Conclusions: Posterior petrosal approaches can provide an excellent exposure of the retrochiasmatic region. Of these two approaches, namely, transcrusal and retrolabyrinthine with hearing preservation, the transcrusal approach offers greater exposure than the retrolabyrinthine approach. The beneficial effect of partial labyrinthectomy of the transcrusal approach to the retrochiasmatic region is accentuated in the exposure of the horizontal distance with less temporal lobe retraction. © 2010 Springer-Verlag. 続きを見る
3.

論文

論文
Hayashi, Yasuhiko ; Tachibana, Osamu ; Mohri, Masanao ; Kinoshita, Masashi ; Hayashi, Yutaka ; Yoshinaga, Tomofumi ; Hamada, Jun-ichiro
出版情報: European Journal of Radiology Extra.  66  pp.e1-e3,  2008-04-01.  Elsevier
URL: http://hdl.handle.net/2297/9559
概要: We encountered a 49-year-old female presenting with left oculomotor palsy who was found to be co-localized cavernous sin us cavernous angioma (CA) and pituitary adenoma. Although CA originated from parasellar regions are not so rare, on neuroimaging studies, the characteristics of CA may be difficult to differentiate from those of pituitary adenomas. The co-localization of these two tumors was identified by preoperative dynamic MRI study. As intraoperative histological examination confirmed our preoperative diagnosis, we performed biopsy of the CA only to avoid uncontrollable intraoperative hemorrhage. © 2008 Elsevier Ireland Ltd. All rights reserved. 続きを見る
4.

論文

論文
Hayashi, Yasuhiko ; Shima, Hiroshi ; Kita, Daisuke ; Kinoshita, Masashi ; Yoshida, Yuya ; Hasegawa, Mitsuhiro ; Hamada, Jun-ichiro
出版情報: Journal of Clinical Neuroscience.  16  pp.568-570,  2009-04-01.  Elsevier
URL: http://hdl.handle.net/2297/17156
概要: 金沢大学附属病院脳神経外科<br />A 41-year-old man presented with exophthalmos and loss of visual acuity. Neuroradiological studies sh owed a large mass extending from the intraorbital region to the frontal lobe. In addition, it also involved the middle cranial and infratemporal fossae with accompanying skull destruction. The tumor was almost totally removed. The histological diagnosis was sebaceous carcinoma with pagetoid changes. Despite surgery and local irradiation, intracranial metastases were recognized one year later, and the patient underwent total tumor removal and whole-brain irradiation. Although multiple lung metastases were detected one year after the second operation, three years post-surgery he remains free of intracranial tumor recurrence. Sebaceous carcinoma of meibomian gland origin with pagetoid changes is a distinct, highly aggressive clinical entity. Early diagnosis and appropriate treatment are essential to improve the prognosis of patients with meibomian gland carcinoma with intracranial extension. © 2008 Elsevier Ltd. All rights reserved. 続きを見る
5.

論文

論文
Hayashi, Yasuhiko ; Shima, Hiroshi ; Kinoshita, Masashi ; Nakada, Mitsutoshi ; Miyashita, Katsuyoshi ; Hamada, Jun-ichiro
出版情報: Journal of Clinical Neuroscience.  16  pp.1075-1077,  2009-08-01.  Elsevier
URL: http://hdl.handle.net/2297/18758
概要: 金沢大学附属病院脳神経外科<br />A 30-year-old man presented with a history of several convulsive episodes. A CT scan showed a calcifi ed focus in the right temporal lobe. Cerebral angiography yielded no abnormal findings. At craniotomy, the M3 portion of the middle cerebral artery was found to terminate with a blind end at the junction with the calcified mass. A pathological diagnosis of an ossified cerebral aneurysm was made. Calcified cerebral aneurysms are not rare; they are thought to be the result of intra-aneurysmal thrombosis or degenerative changes in the aneurysmal wall. However, complete mural ossification of a cerebral aneurysm is seldom seen, and ossified peripheral middle cerebral artery aneurysms are extremely rare in young individuals. The ossified aneurysm that we report developed over a prolonged period and may have arisen during childhood. © 2008 Elsevier Ltd. All rights reserved. 続きを見る
6.

論文

論文
Hayashi, Yasuhiko ; Shima, Hiroshi ; Miyashita, Katsuyoshi ; Kinoshita, Masashi ; Nakada, Mitsutoshi ; Kida, Shinya ; Hamada, Jun-ichiro
出版情報: Neurologia Medico-Chirurgica.  48  pp.216-219,  2008-01-01.  日本脳神経外科学会
URL: http://hdl.handle.net/2297/25179
概要: 金沢大学医薬保健研究域医学系<br />金沢大学附属病院脳神経外科<br />A 48-year-old man presented with a pseudoaneurysm at the cervical portion of the left internal carotid artery (ICA) secondary to infection in the deep neck space. Magnetic resonance (MR) imaging demonstrated enhancement of the wall of the ICA and a pseudoaneurysm, considered to be sequelae of infection spread. ICA occlusion occurred on the next day resulting in sudden onset of right hemiparesis and motor aphasia. The ICA pseudoaneurysm shrank gradually and his neurological deficits improved with conservative therapy. One month later, he presented with aneurysm regrowth. The common carotid artery was occluded with Guglielmi detachable coils to block arterial flow into the pseudoaneurysm. There were no neurological complications. Marked enhancement of the ICA wall on computed tomography and MR imaging may indicate the possibility of vascular complications such as rupture, pseudoaneurysm development, or ICA occlusion, and consequent neurological deficits. ICA occlusion caused by spread of infection in the deep neck space may cause accelerated coagulopathy due to ICA wall inflammation. 続きを見る
7.

論文

論文
木下, 雅史 ; Kinoshita, Masashi
出版情報: 平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書 = 2016 Fiscal Year Final Research Report.  2015-04-01 - 2017-03-31  pp.4p.-,  2017-06-12. 
URL: http://hdl.handle.net/2297/00051767
概要: 金沢大学医薬保健研究域医学系<br />「心の理論」機能の局在を明らかにするために、覚醒下脳手術を行った右前頭葉グリオーマ15症例において、心の理論タスクによるマッピングデータを収集した。マッピングと機能局在に関して、複数症例において皮質及 び皮質下に再現性のある心の理論タスクの遂行困難な領域を確認し、仮説であった心の理論と関連する白質神経線維束Aとの存在が疑われるマッピング結果が得られた。さらに、術前後の経時的な心の理論の検査結果ならびにボクセル単位脳形態学的解析の結果から、右前頭葉手術において白質神経線維束Aが解剖学的に温存された場合、心の理論の維持・改善が期待できることがわかった。<br />From the data of intraoperative mapping using theory of mind task in awake craniotomy for 15 right frontal gliomas, reproducible positive mappings could be confirmed in cortical and subcortical areas, and then overlapped on tractography and standardized brain MRI. A white matter tract "A" was a candidate tract subserving a network of mentalizing because of the three-dimensional distribution of positive mapping on the bundle in tractography and significant relationships between postoperative impairment of mentalizing and resected cavity including the white matter tract A in voxel-based lesion-symptom mapping analysis. This study suggested that structural preservation of white matte tract A would be able to maintain and improve mentalizing postoperatively in the resection of right frontal glioma.<br />研究課題/領域番号:15K19957, 研究期間(年度):2015-04-01 - 2017-03-31 続きを見る
8.

論文

論文
木下, 雅史 ; Kinoshita, Masashi
出版情報: 平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書 = 2011 Fiscal Year Final Research Report.  2010-2011  pp.4p.-,  2012-05-21.  金沢大学医薬保健研究域医学系
URL: http://hdl.handle.net/2297/00051768
概要: 下前頭回と上前頭回を連絡する神経繊維束の存在を疑い、fiber dissectionとMRIによる解析を行った。その結果、本神経線維束の同定に成功するとともに、ブローカ言語中枢と外側上前頭回を連絡する解剖学的特徴を持つこと、左側大脳半球優位 な偏在性の性質を持ち男性に強い傾向があること、その所見が弓状束の特徴と共通することから、本線維束が言語ネットワークに関係している可能性が示唆された。またこれらの結果は、術中言語マッピングにおいて外側上前頭回刺激時にみられる発語障害を説明しうると考えられた。<br />The association fibers connecting the inferior and superior frontal gyri were analyzed using fiber dissection and MRI techniques. The fibers were anatomically identified to connect between the Broca center and the lateral superior frontal gyrus, and existed dominantly in left cerebral hemisphere and male population. The anatomical feature was common to that of the arcuate fascicle. These findings suggest a close relationship between this pathway and language organization, and may explain speech disturbances induced by lateral superior frontal gyrus stimulation that were sometimes observed during intraoperative language mapping.<br />研究課題/領域番号:22791338, 研究期間(年度):2010-2011 続きを見る
9.

論文

論文
木下, 雅史 ; Kinoshita, Masashi
出版情報: 令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 = 2019 Fiscal Year Final Research Report.  2017-04-01 - 2020-03-31  pp.19p.-,  2020-05-25. 
URL: http://hdl.handle.net/2297/00057904
概要: 金沢大学医薬保健研究域医学系<br />人の感情の情動面に関わる共感性について、機能領域と白質神経ネットワークの解析を行った。これまで開発に至った次世代覚醒下手術において使用可能な共感性評価タスクを作成し、健常成人の机上データをもとに脳腫瘍 であるグリオーマ症例において術中評価が可能であることを証明した。次に右前頭葉グリオーマ患者において共感性タスクを用いた術中評価を行い、各種MRIデータから、人の感情と共感性に関わる神経ネットワークの存在が示唆された。さらに術後の「意欲」への関与が疑われた。感情-共感性-意欲に関わるマルチモーダルネットワークの解明のため、引き続き意欲関連ネットワークに関する発展研究を行う予定である。<br />We analyzed the functional areas and white matter networks of empathy related to human emotions. We established an empathy evaluation task that could be used in our developed awake craniotomy, and proved that it could be assessed intraoperatively in glioma cases, based on standard data from healthy adults. Next, we performed an intraoperative evaluation using the empathy task in patients with right frontal glioma, and various MRI data suggested the existence of a neural network involved in human emotion and empathy. Further involvement in postoperative "motivation" was suspected. In order to elucidate the multimodal network related to emotion, empathy, and motivation, we will continue to conduct developmental research on motivation-related networks.<br />研究課題/領域番号:17K10859, 研究期間(年度):2017-04-01 - 2020-03-31<br />出典:「次世代覚醒下脳手術を応用した共感性ネットワークの解明と温存」研究成果報告書 課題番号17K10859(KAKEN:科学研究費助成事業データベース(国立情報学研究所))(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10859/17K10859seika/)を加工して作成 続きを見る