※一部利用できない機能があります
| 1.
学位論文 |
学位
|
齋藤, 裕人 ; Saito, Hiroto
概要:
博士論文要旨Abstract 以下に掲載：Gastric Cancer Online pp.1-13 2017. Springer. 共著者：Hiroto Saito, Sachio Fushida, Shinichi Harada, To
…
moharu Miyashita, Katsunobu Oyama, Takahisa Yamaguchi, Tomoya Tsukada, Jun Kinoshita, Hidehiro Tajima, Itasu Ninomiya,Tetsuo Ohta
続きを見る
|
||||
| 2.
学位論文 |
学位
|
齋藤, 裕人 ; Saito, Hiroto
概要:
博士論文本文Full 以下に掲載：Gastric Cancer Online pp.1-13 2017. Springer. 共著者：Hiroto Saito, Sachio Fushida, Shinichi Harada, Tomoha
…
ru Miyashita, Katsunobu Oyama, Takahisa Yamaguchi, Tomoya Tsukada, Jun Kinoshita, Hidehiro Tajima, Itasu Ninomiya,Tetsuo Ohta
続きを見る
|
||||
| 3.
論文 |
論文
|
Okamoto, Koichi ; Ninomiya, Itasu ; Maruzen, Shogo ; Saito, Hiroto ; Tsukada, Tomoya ; Kinoshita, Jun ; Makino, Isamu ; Nakamura, Keishi ; Oyama, Katsunobu ; Miyashita, Tomoharu ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Kitagawa, Hirohisa ; Fushida, Sachio ; Fujimura, Takashi ; Ohta, Tetsuo
概要:
Background: Tachyarrhythmia after esophagectomy is a severe complication that should not be underestimated because of it
…
s negative impact. The aims of this study were to clarify the cause and impact of postoperative tachyarrhythmia after thoracoscopic esophagectomy. Additionally, we analyzed the usefulness of landiolol administration for postoperative tachyarrhythmia. Methods: We evaluated the predictive factors for tachyarrhythmia onset after surgery and its clinical impact in 127 patients who underwent thoracoscopic esophagectomy with extended lymphadenectomy. Moreover, we analyzed the efficacy of landiolol for postoperative tachyarrhythmia. Results: Tachyarrhythmia developed in 38 of the 127 patients. Multivariate analysis showed that advanced age, heart disease, and hyperlipidemia were associated with postoperative tachyarrhythmia. Hyponatremia, hypoalbuminemia, and leukocytosis on postoperative day 3 were significantly associated with tachyarrhythmia onset. The incidence of all complications and respiratory complications, including pneumonia, was significantly higher in patients with than in those without tachyarrhythmia. The mortality rate in the tachyarrhythmia group tended to be higher than that in the nontachyarrhythmia group. Landiolol as a treatment for tachyarrhythmia immediately decreased heart rate and safely reduced subsequent respiratory complications. Conclusion: In elderly patients with cardiac disease or hyperlipidemia, surgeons should be alert for the occurrence of tachyarrhythmia after esophagectomy. Postoperative tachyarrhythmia is a marker of morbidities with particular emphasis on respiratory complications. However, it can be adequately managed by landiolol, resulting in fewer respiratory complications. Landiolol might be a safe and convenient agent for managing postoperative tachyarrhythmia after thoracoscopic esophagectomy, resulting in lower mortality and morbidity rates. © 2013 The Japan Esophageal Society and Springer.
続きを見る
|
||||
| 4.
論文 |
論文
|
Saito, Hiroto ; Fushida, Sachio ; Miyashita, Tomoharu ; Oyama, Katsunobu ; Yamaguchi, Takahisa ; Tsukada, Tomoya ; Kinoshita, Jun ; Tajima, Hidehiro ; Ninomiya, Itasu ; Ohta, Tetsuo
概要:
Background: The theory of extravasated platelet aggregation in cancer lesions was recently introduced. We investigated t
…
he association of platelet aggregation in gastric cancer stroma with clinicopathological features, chemotherapeutic response, pathological response, and survival. Methods: The study comprised 78 patients with advanced gastric cancer who had undergone gastrectomy with or without combination of docetaxel, cisplatin and S-1 (DCS) as preoperative chemotherapy between 2005 and 2014. The patients were divided into two groups: patients who had received preoperative DCS therapy forming the p-DCS group and patients who had not received preoperative DCS therapy forming the control group. The 39 patients in the control group had received gastrectomy and postoperative chemotherapy of S-1 alone. Platelet aggregation in biopsy specimens before preoperative DCS therapy in the p-DCS group and at the time of diagnosis in the control group were evaluated using CD42b immunohistochemical staining. Results: Twenty-four patients in the p-DCS group and 19 in the control group were found to have platelet aggregation in their cancer stroma. Patients with histologically confirmed platelet aggregation had significantly higher rates of chemoresistance (58.3%) than those without platelet aggregation (20.0%) (P = 0.019). According to multivariate analysis, CD42b expression (odds ratio: 5.102, 95% confidence interval: 1.039-25.00, P = 0.045) was correlated with chemoresistance. CD42b expression and histological non-responder status were both significantly correlated with poor overall survival (OS) (P = 0.012, P = 0.016); however, RECIST was not correlated with OS. In the control group, CD42b expression was also significantly correlated with poor overall survival (OS) (P = 0.033). In the p-DCS group, according to multivariate analysis, male sex (hazard ratio: 0.281, 95% confidence interval: 0.093-0.846, P = 0.024) was correlated with good prognosis and CD42b expression (hazard ratio: 4.406, 95% confidence interval: 1.325-14.65, P = 0.016) with poor prognosis. Conclusions: This study suggests that platelets in gastric cancer stroma may create a favorable microenvironment for chemoresistance. CD42b immunohistochemical staining of biopsy specimens is a promising candidate for being a prognostic marker in patients with gastric cancer. © 2017 The Author(s).
続きを見る
|
