※一部利用できない機能があります
| 1.
図書 |
図書
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Timothy R. Parsons and Masayuki Takahashi, and Barry Hargrave
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| 2.
その他 |
その他
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高橋, 正行 ; Takahashi, Masayuki
概要:
取得学位：博士(工学)，学位授与番号：博甲第146号，学位授与年月日：平成7年3月25日,学位授与年：1995
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| 3.
論文 |
論文
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Shimizu, Hiroko ; Popova, Milena ; Fleury, Fabrice ; Kobayashi, Masahiko ; Hayashi, Naoyuki ; Sakane, Isao ; Kurumisaka, Hitoshi ; Venkitaraman, Ashok R. ; Takahashi, Masayuki ; Yamamoto, Ken-ichi
概要:
金沢大学がん研究所がん分子細胞制御<br />The assembly of RAD51 recombinase on DNA substrates at sites of breakage is essential for their r
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epair by homologous recombination repair (HRR). The signaling pathway that triggers RAD51 assembly at damage sites to form subnuclear foci is unclear. Here, we provide evidence that c-ABL, a tyrosine kinase activated by DNA damage which phosphorylates RAD51 on Tyr-315, works at a previously unrecognized, proximal step to initiate RAD51 assembly. We first show that c-ABL associates with chromatin after DNA damage in a manner dependent on its kinase activity. Using RAD51 mutants that are unable to oligomerize to form a nucleoprotein filament, we separate RAD51 assembly on DNA to form foci into two steps: stable chromatin association followed by oligomerization. We show that phosphorylation on Tyr-315 by c-ABL is required for chromatin association of oligomerization-defective RAD51 mutants, but is insufficient to restore oligomerization. Our findings suggest a new model for the regulation of early steps of HRR. © 2009 Elsevier Inc. All rights reserved.
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| 4.
論文 |
論文
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Shimizu, Hiroko ; Kitayama, Satoko ; Kobayashi, Masahiko ; Kurumisaka, Hitoshi ; Takahashi, Masayuki ; Yamamoto, Ken-ichi
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