※一部利用できない機能があります
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver
- フォーマット:
- 論文
- 責任表示:
- Wu, Yu ; Wang, Ying Ying ; Nakamoto, Yasunari ; Li, Ying-Yi ; Baba, Tomohisa ; Kaneko, Shuichi ; Fujii, Chifumi ; Mukaida, Naofumi
- 言語:
- 英語
- 出版情報:
- Nature Publishing Group, 2010-04-01
- 著者名:
Wu, Yu Wang, Ying Ying Nakamoto, Yasunari Li, Ying-Yi Baba, Tomohisa Kaneko, Shuichi Fujii, Chifumi Mukaida, Naofumi - 掲載情報:
- Oncogene
- ISSN:
- 0950-9232
- 巻:
- 29
- 通号:
- 15
- 開始ページ:
- 2228
- 終了ページ:
- 2237
- バージョン:
- author
- 概要:
- 金沢大学がん研究所<br />Pim-3, a proto-oncogene with serine/threonine kinase activity, was enhanced in hepatocellular carcinoma (HCC) tissues. To address the roles of Pim-3 in HCC development, we prepared transgenic mice that express human Pim … -3 selectively in liver. The mice were born at a Mendelian ratio, were fertile and did not exhibit any apparent pathological changes in the liver until 1 year after birth. Pim-3-transgenic mouse-derived hepatocytes exhibited accelerated cell cycle progression. The administration of a potent hepatocarcinogen, diethylnitrosamine (DEN), induced accelerated proliferation of liver cells in Pim-3 transgenic mice in the early phase, compared with that observed for wild-type mice. Treatment with DEN induced lipid droplet accumulation with increased proliferating cell numbers 6 months after the treatment. Eventually, wild-type mice developed HCC with a frequency of 40% until 10 month after the treatment. Lipid accumulation was accelerated in Pim-3 transgenic mice with higher proliferating cell numbers, compared with that observed for wild-type mice. Pim-3 transgenic mice developed HCC with a higher incidence (80%) and a heavier burden, together with enhanced intratumoral CD31-positive vascular areas, compared with that observed for wild-type mice. These observations indicate that Pim-3 alone cannot cause, but can accelerate HCC development when induced by a hepatocarcinogen, such as DEN. © 2010 Macmillan Publishers Limited. All rights reserved. 続きを見る
- URL:
- http://hdl.handle.net/2297/24282
類似資料:
Japanese Cancer Association / Blackwell Publishing Ltd | |
8
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