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山田, 正仁 ; Yamada, Masahito
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Muroishi, Toyoteru ; Sakai, Kenji ; Yanase, Daisuke ; Ikeda, Yoshihisa ; Machiya, Tomohiko ; Kato-Motozaki, Yuko ; Samuraki, Miharu ; Yamada, Masahito ; 坂井, 健二 ; 山田, 正仁
概要:
金沢大学附属病院神経内科<br />We report the case of a 57-year-old man with neuromyelitis optica spectrum disorder (NMOSD) presenting
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as acute eosinophilic encephalomyelitis. Magnetic resonance imaging revealed central nervous system lesions typical of NMOSD and anti-aquaporin-4 antibodies in the serum were identified; however, eosinophilia was evident in the cerebrospinal fluid (CSF) at the early stage of the disease. The number of eosinophils in the CSF decreased subsequently. Although activation of eosinophils is known to be an important factor in the development of NMOSD lesions, prominent eosinophilia in the CSF at the early stage of the disease has never been reported in patients with NMOSD. © 2017 Elsevier Ltd.<br />Embargo Period 12 months
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山田, 正仁 ; Yamada, Masahito
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Sakai, Kenji ; Asakawa, Miwako ; Takahashi, Ryoichi ; Ishida, Chiho ; Nakamura, Ritsuko ; Hamaguchi, Tsuyoshi ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito ; 坂井, 健二 ; 中村, 律子 ; 濵口, 毅 ; 小野, 賢二郎 ; 岩佐, 和夫 ; 山田, 正仁
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金沢大学附属病院神経内科<br />Embargo Period 12 months
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Furukawa, Yutaka ; Yoshikawa, Hiroaki ; Iwasa, Kazuo ; Yamada, Masahito
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金沢大学保健管理センター<br />115<br />To clarify the long-term efficacy, safety and the cytokine network-modulating effects of tacr
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olimus in myasthenia gravis, medical records of 86 newly diagnosed consecutive patients and nine steroid-dependent patients were retrospectively reviewed, and peripheral blood mononuclear cells (PBMC) were cultured for the cytokine profile. Steroid reduction effects were observed by using tacrolimus, and no serious adverse effects were observed. The culture study showed reduced IL-12, IL-17, IFN-γ, GM-CSF, TNF-α and MIP-1β, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells. © 2008 Elsevier B.V. All rights reserved.
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Kobayashi, Shota ; Yokoyama, Shigeru ; Maruta, Takahiro ; Negami, Masako ; Muroyama, Akiko ; Mitsumoto, Yasuhide ; Iwasa, Kazuo ; Yamada, Masahito ; Yoshikawa, Hiroaki
概要:
Autoantibody against nicotinic acetylcholine receptor (nAChR) α3 subunit has been implicated in the pathogenesis of para
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neoplastic neurological syndrome. To examine the effect of anti-α3 subunit autoantibody on cell-surface nAChRs, we established human embryonic kidney 293 cells stably co-expressing α3 and β4 subunits. Upon incubation with seropositive patient's serum, this cell line showed co-accumulation of patient's IgG and α3 subunits in the cytoplasm. These data support the hypothesis that anti-α3 subunit autoantibody induces internalization of cell-surface nAChRs and thereby impairs synaptic transmission. © 2012 Elsevier B.V. All rights reserved.
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Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
概要:
金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth
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enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved.
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Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
概要:
金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth
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enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved.
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Noto, Daisuke ; Takahashi, Kazuya ; Miyake, Sachiko ; Yamada, Masahito
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金沢大学医薬保健研究域医学系<br />Microglia are believed to be the only resident immune cells in the CNS, originating from hematopoiet
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ic-derived myeloid cells and invading the CNS during development. However, the detailed mechanisms of differentiation and transformation of microglial cells are not fully understood. Here, we demonstrate that murine microglial cells show two morphological forms in vitro, namely, small round cells expressing CD11b, Iba1, triggering receptor expressing on myeloid cells-2 (TREM2), and weakly expressing major histocompatibility complex class II and large flat cells expressing only CD11b and Iba1. Moreover, lineage-negative bone marrow (LN) cells cultured with primary mixed glial culture cells could differentiate into only the small round microglia-like cells, despite the absence of CCR2 and Gr-1 expression. Addition of macrophage colony stimulating factor (M-CSF) to LN cell culture allowed the proliferation and expression of TREM2 in LN cells, and the addition of neutralizing anti-M-CSF antibodies suppressed the proliferation of LN cells despite the expression of TREM2. When LN cells were cultured with M-CSF, the number of small round cells in the culture was considerably low, indicating that the small round morphology of the immature cells is not maintained in the presence of only M-CSF. On the other hand, when LN cells were grown in the presence of astrocytes, the small round cells were maintained at a concentration of approximately 30% of the total population. Therefore, cell-cell contact with glial cells, especially astrocytes, may be necessary to maintain the small round shape of the immature cells expressing TREM2. © Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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Yoshita, Mitsuhiro ; Ishida, Chiho ; Yanase, Daisuke ; Yamada, Masahito
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金沢大学医薬保健研究域医学系<br />Myasthenic symptoms and the echocardiographic findings of dilated cardiomyopathy are very rare in pr
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imary AL amyloidosis. We report a 59yearold man with dyspnea on effort and weakness after exercise. His electrocardiogram showed ischemic heart disease and echocardiography indicated dilated cardiomyopathy. Muscle biopsy revealed amyloidosis with deposits of lambda light chainderived amyloid within the vessel wall. Treatment with PGE1 resulted in improvement of the myasthenic symptoms. This patient indicates that myasthenic symptoms and dilated cardiomyopathy would be a unique syndrome associated with systemic AL amyloidosis involving mainly the small vessels, i.e., AL amyloid angiopathy, in the skeletal muscles and myocardium vessels.
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