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サース・アンドラーシュ, 盛田常夫著
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市瀬史著
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吉川敏一著
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平岡真寛, 田中良明編集
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田村, 昌也 ; Tamura, Masaya
概要:
共同研究施設より貸与をうけた磁性流体を用い、細胞への磁性流体への取り込みを確認する実験を追加して行った。細胞株211Hに磁性流体を添付した溶液を遠心分離し、その上清、細胞の各々のFe含有量をICP-MS法にて測定した。細胞成分にFeの取り込
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みが確認できた。小型動物を加温する加温器を本学工学部と作成し、小型動物（ヌードマウス：250g）の加温実験を行った。腹部皮下に1mlの磁性流体を注入し、加温を行った。2~5分で42-42℃の温度上昇を得た。5匹に実験を施行し、全例加温後も生存を確認した。明らかな有害事象はなかった。<br />Using the magnetic fluid loaned from the collaborative research facility, experiments were performed to confirm uptake into the magnetic fluid into cells. The magnetic fluid was attached to the cell line 211H, the solution after 24 hours was centrifuged, and the Fe content of each of the supernatant and the cells was measured by ICP-MS methods. The uptake of Fe was confirmed in the cellular components. A small-sized heater for small animals, such as mouse, rat was created. Using this, a heating experiment of a small animals (nude mouse: 250g) was performed. The 1ml magnetic fluid was injected into abdomen subcutaneously. A temperature rise of 42-43℃ was obtained in 2 to 5 minutes. The experiment was conducted on 5 animals and survival was confirmed after heating in all cases. No obvious adverse events such as skin burns were identified.<br />研究課題/領域番号:16K10702, 研究期間(年度):2016-04-01 - 2019-03-31
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伊藤要子著
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