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渡辺孝著
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論文
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中谷, 壽男 ; Nakatani, Toshio
概要:
金沢大学医薬保健研究域保健学系<br />1．鼡径リンパ節を切除してマウスの後肢に浮腫を作製し，浮腫部位に皮膚創傷を作製した．浮腫が継続しなかったために，創傷の治癒にリンパ浮腫が影響するかは不明であった．2．蜂蜜のマウスのIII度熱傷治癒へ
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の効果はほとんど見られなかった．3．女性ホルモンのエストロゲンは高齢，栄養不良のマウス皮膚創傷治癒への効果がみられた． 4．アルゴンガスに高電圧をかけて発生させるプラズマはマウス皮膚創傷治癒を早める可能性があることが判明した．<br />A mouse model of lymphedema after inguinal lymphadenectomy with a skin would at the same site was created to examine the influences of the condition. Honey, and estrogen as a female hormone on would healing were examined. The following findings were obtained: the influence of lymphedema on the wound healing remained unclear, as lymphedema did not persist; the effect of honey on the third-degree burn was poor; estrogen positively affected wound healing in elderly and malnourished mice; and a plasma jet generated by applying a high voltage to argon gas was also suggested to promote would healing.<br />研究課題/領域番号:25293430, 研究期間(年度):2013-04-01 – 2016-03-31
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論文 |
論文
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中谷, 壽男 ; Nakatani, Toshio
概要:
マウスの皮膚創傷全層欠損創に対する治癒への影響を検討した.エストロゲンは卵巣摘出のマウスで創傷治癒促進効果があったが,雄マウスには効果がなかった.効果は雌のみなのかはさらに検討の余地がある.イソフラボンの創傷治癒促進効果はほとんど無かった.
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肥満マウスは,創作製後に急激に痩せたので,肥満が治癒を遅延させるかは不明であった.リンパ管新生の抑制は治癒を遅延させるようだ.蜂蜜は種類によって創傷または熱傷創の治癒効果は異なることから,いろいろな種類を試す必要がある.<br />We investigated factors that affect the healing of full-thickness cutaneous wounds in mice. Estrogen was effective for wound healing in ovariectomized mouse, but not in male mouse. There is room for further investigation on whether it is effective only in females. The effect of isoflavone on wound healing was not clear. It was also unclear whether obesity caused a delay of wound healing because the obese mice dramatically lost weight after wounding. It is thus necessary to re-examine models of obesity. Inhibition of lymphangiogenesis seemed to delay the healing. Since the effect of honey on wounds or burn wounds depended on the type of honey, it is necessary to evaluate several kinds of honey.<br />研究課題/領域番号:22592363, 研究期間(年度):2010–2012
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