1.

図書

図書
editor, Heinz Furthmayr
出版情報: Boca Raton, Fla. : CRC Press, c1982
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2.

図書

図書
edited by Elizabeth D. Hay
出版情報: New York : Plenum Press, c1991
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3.

図書

図書
by Ilona Banga ; [ms. rev. by Gy. Romhányi and M. Németh-Csóka ; translated by E. Farkas]
出版情報: Budapest : Akadémiai Kiadó, 1966
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4.

図書

図書
edited by Richard Mayne, Robert E. Burgeson
出版情報: San Diego ; Tokyo : Academic Press, c1987
シリーズ名: Biology of extracellular matrix ; A series
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5.

図書

図書
editors, Karl A. Piez, A.H. Reddi
出版情報: New York : Elsevier, c1984
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6.

図書

図書
sponsored by the New York Heart Association
出版情報: Boston : Little, Brown, c1964
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7.

図書

図書
edited by Jaqueline B. Weiss, Malcolm I.V. Jayson
出版情報: Edinburgh ; New York : Churchill Livingstone, 1982, c1983
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8.

図書

図書
edited by G.N. Ramachandran
出版情報: London ; New York : Academic P., 1967
シリーズ名: Treatise on collagen ; vol. 1
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9.

図書

図書
edited by Bernard S. Gould
出版情報: London ; New York : Academic Press, 1968
シリーズ名: Treatise on collagen ; v. 2
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10.

論文

論文
Sakai, Katsuya ; Nakamura, Takahiro ; Suzuki, Yoshinori ; Imizu, Takafumi ; Matsumoto, Kunio
出版情報: Biochemical and Biophysical Research Communications.  412  pp.98-103,  2011-08-01.  Elsevier
URL: http://hdl.handle.net/2297/29189
概要: Matrix metalloproteinases (MMPs) play roles in spatially dynamic processes, including morphogenesis, wound healing, and tumor invasion. Three-dimensional (3-D) type I collagen stimulates cellular activation of MMP-2, however, the mechanisms underlying this are controversial. The present study investigated mechanisms for 3-D collagen-induced MMP-2 activation in highly invasive human malignant mesothelioma cells. MMP-2 was effectively activated by cells cultured in 3-D collagen but not in 2-D collagen, whereas MMP-2 activation was not regulated by the flexibility of collagen. The 3-D collagen did not largely increase the gene expression of MMP-2 and MT1-MMP. However, MT1-MMP exposed to the cell surface was much increased by 3-D collagen, and loss of MT1-MMP abolished MMP-2 activation in response to 3-D collagen. MT1-MMP and integrin β1 translocated to pericellular regions interacting with collagen-coated microbeads, however their localization was different. Importantly, inhibition of integrin β1 function and expression did not affect 3-D collagen-induced cell surface localization of MT1-MMP and MMP-2 activation. Our results strongly suggest that 3-D collagen scaffolding may provide opportunity for direct and multivalent interaction with MT1-MMP, by which MMP-2 activation occur in abundant cell surface MT1-MMP-dependent manner, rather than a manner regulated by matrix stiffness and integrin β1 function. © 2011 Elsevier Inc. All rights reserved. 続きを見る