The evolving concept of liver cancer stem cells

フォーマット:

論文

責任表示:

Nio, Kouki ; Yamashita, Taro ; Kaneko, Shuichi

言語:

英語

出版情報:

BioMed Central Ltd., 2017-01-30

著者名:

• Nio, Kouki
• Yamashita, Taro
• Kaneko, Shuichi

掲載情報:

Molecular Cancer

ISSN:

1476-4598      

巻:

16

通号:

1

開始ページ:

4

バージョン:

publisher

概要:

Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism … of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment. © 2017 The Author(s). 続きを見る

URL:

http://hdl.handle.net/2297/47048