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論文

論文
Tajima, Hidehiro ; Takamura, Hiroyuki ; Kitagawa, Hirohisa ; Nakayama, Akira ; Shoji, Masatoshi ; Watanabe, Toshifumi ; Tsukada, Tomoya ; Nakanuma, Shinichi ; Okamoto, Koichi ; Sakai, Seisho ; Kinoshita, Jun ; Makino, Isamu ; Nakamura, Keishi ; Hayashi, Hironori ; Oyama, Katsunobu ; Inokuchi, Masafumi ; Nakagawara, Hisatoshi ; Miyashita, Tomoharu ; Ninomiya, Itasu ; Fushida, Sachio ; Fujimura, Takashi ; Wakayama, Tomohiko ; Iseki, Shoichi ; Ikeda, Hiroko ; Ohta, Tetsuo ; 田島, 秀浩 ; 高村, 博之 ; 北川, 裕久 ; 中村, 信一 ; 岡本, 浩一 ; 木下, 淳 ; 牧野, 勇 ; 中村, 慶史 ; 林, 泰寛 ; 尾山, 勝信 ; 井口, 雅史 ; 中川原, 寿俊 ; 宮下, 知治 ; 二宮, 致 ; 若山, 友彦 ; 藤村, 隆 ; 井関, 尚一 ; 池田, 博子 ; 太田, 哲生
出版情報: Oncology Letters.  9  pp.1733-1738,  2015-04.  Spandidos Publications
URL: http://hdl.handle.net/2297/00049839
概要: 金沢大学医薬保健研究域医学系<br />A 33-year-old female was diagnosed with a solid pseudopapillary tumor (SPT) of the pancreas and mult iple liver metastases at the Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital (Kanazawa, Japan). Distal pancreatectomy and postoperative systemic chemotherapy with gemcitabine (GEM) and S-1, an oral fluoropyrimidine derivative, was administered, however, liver metastases became enlarged and local recurrence occurred. Therefore, the patient was referred to the Department of Gastroenterologic Surgery at the Graduate School of Medicine (Kanazawa, Japan) for hepatic arterial infusion (HAI) chemotherapy. Oral S-1 (80 mg/m2) was administered as well as HAI chemotherapy with GEM (1,000 mg/standard liver volume). Following 18 cycles, tumor sizes were reduced and 18-fluorodeoxyglucose positron emission tomography (18FDG-PET) examination revealed obvious reduction of tumor FDG uptake. Transarterial tumor embolization (TAE) was performed for the previously unresectable right subphrenic liver tumor, and the other tumors were surgically resected. The resected tumors were diagnosed as liver metastases and a local recurrence of SPT in the postoperative pathological examination, which revealed that the resected tumors were composed of sheets of bland cells, which were positive for CD10, CD56, vimentin, neuron-specific enolase and α-antitrypsin. The postoperative course was uneventful, and the patient is currently under observation at an outpatient clinic; postoperative adjuvant chemotherapy with oral S-1 has continued, and additional TAE is planned. In the future, if the middle segment of the liver becomes enlarged, surgery for the residual right lobe tumor may be possible. This case demonstrates one method of SPT treatment: Preoperative HAI chemotherapy with GEM, plus oral S-1 and TAE. If complete resection can be achieved, the majority of patients with SPT have a favorable prognosis. In patients with unresectable metastases from SPT, it is crucial to conduct systematic multimodal treatment to maximize treatment success. © 2015, Spandidos Publications. All Rights Reserved.<br />Embargo Period 6 months 続きを見る
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論文

論文
Gabata, Toshifumi ; Matsui, Osamu ; Terayama, Noboru ; Kobayashi, Satoshi ; Sanada, Junichiro
出版情報: Abdominal Imaging.  33  pp.437-443,  2008-07-01.  Springer Verlag (Germany)
URL: http://hdl.handle.net/2297/9986
概要: 金沢大学医薬保健研究域医学系<br />We aimed to evaluate the imaging findings of hepatic metastases from pancreatic cancers, especially wedge-shaped enhancement and its etiology. Dynamic CT and MR images were performed in 87 patients with liver metastases from pancreatic carcinomas, and CT during arterial portography (CTAP) and CT during hepatic arteriography (CTHA) in 51 patients. Liver metastases were multiple in 84 patients (97%) and solitary in only three (3%). In 44 of 87 patients (51%), all liver metastases showed ring-like enhancement compatible with metastatic adenocarcinomas on dynamic CT and/or dynamic MR imaging. In 37 patients, more than one metastatic lesion showed wedge-shaped contrast enhancement on dynamic CT, dynamic MRI and CTHA, and wedge-shaped perfusion defect on CTAP adjacent to metastatic tumors. Six patients showed multiple wedge-shaped enhancements, which were initially diagnosed as multiple arterioportal shunts (AP shunts). However, metastatic tumors appeared within the area of wedge-shaped enhancement and increased in size on follow-up CT and/or MR images. After all, 43 of 87 patients (49%) had AP shunt like contrast enhancement adjacent to liver metastases. Liver metastases from pancreatic carcinomas frequently show transient wedge-shaped enhancement, and should not be misdiagnosed as nontumorous arterioportal shunts. © 2007 Springer Science+Business Media, LLC. 続きを見る
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論文

論文
Yang, Xiaoqin ; Lu, Peirong ; Ishida, Yuko ; Kuziel, William A. ; Fujii, Chifumi ; Mukaida, Naofumi
出版情報: International Journal of Cancer.  118  pp.335-345,  2006-11-15.  Wiley-Liss
URL: http://hdl.handle.net/2297/6665
概要: 金沢大学がん研究所がん病態制御<br />The liver parenchyma is populated by hepatocytes and several nonparenchymal cell types, including K upffer cells and hepatic stellate cells. Both Kupffer cells and hepatic stellate cells are responsive to the chemokine CCL2, but the precise roles of CCL2 and these cells in liver tumor formation remain undefined. Hence, we investigated the effects of the lack of the major CCL2 receptor, CCR2, on liver tumor formation induced by intraportal injection of the murine colon adenocarcinoma cell line, colon 26. Wild-type mice showed macroscopic tumor foci in the liver 10 days after injection of colon 26 cells. After 10 days, CCL2 proteins were detected predominantly in tumor cells, coincident with increased intratumoral macrophage and hepatic stellate cell numbers. Although tumor formation occurred at similar rates in wild-type and CCR2-deficient mice up to 10 days after tumor cell injection, the number and size of tumor foci were significantly attenuated in CCR2-deficient mice relative to wild-type mice thereafter. Moreover, neovascularization and matrix metalloproteinase 2 expression were diminished in CCR2-deficient mice with a concomitant reduction in the accumulation of macrophages and hepatic stellate cells. Furthermore, matrix metalloproteinase 2 was detected predominantly in hepatic stellate cells but not in macrophages. We provided the first definitive evidence that the absence of CCR2-mediated signals can reduce the trafficking of hepatic stellate cells, a main source of matrix metalloproteinase 2, and consequently can diminish neovascularization during liver tumor formation. © 2005 Wiley-Liss, Inc. 続きを見る
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論文

論文
高橋, 豊 ; Takahashi, Yutaka
出版情報: 平成14(2002)年度 科学研究費補助金 基盤研究(C) 研究報告書概要 = 2002 Fiscal Year Final Research Report Summary.  2001 – 2002  pp.2p.-,  2004-04-13. 
URL: http://hdl.handle.net/2297/00063762
概要: 金沢大学がん研究所<br />ヌードマウスに同所移植(胃癌細胞を胃など)すると何らかの血管新生因子の発現が亢進し、これが血管新生を高め、転移や増殖活性につながることが知られている。今回、Vascular endothelial growth factor(VEGF)が亢進するKKLS胃癌株とBasic fibroblast growth factor(bFGF)が亢進するKM12sm大腸癌株(いずれも高率に肝転移を伴う)を対象に、それぞれの株に体し、抗VEGF抗体を同所移植後3週目より、100μgx2/w投与した。血管新生抑制能としての対照として、既に血管内皮細胞の増殖抑制による血管新生抑制能を報告したポリアミン阻害剤のDFMOを用いた。13週目にマウスをすべて屠殺し、転移の有無をみるとともに、抗VEGF抗体治療がなされたKKLSにおけるVEGF, bFGFの発現をmRNAレベルで解析した。その結果、13週目における肝転移の発生率は、対照群のDFMO投与群で、KKLS 3/10,KM12sm 2/10と同程度の抑制率であったが、抗VEGF抗体投与群では、VEGF依存性のKKLS 1/10に対し、KM12sm 7/10と大きな差が認められた。またVEGF抗体治療がなされたKKLS腫瘍のVEGF, bFGFのmRNAレベルに変化は認められなかった。以上より、抗VEGF抗体による治療は、VEGFの高発現の腫瘍を対象とすることが、重要と思われた。また本治療によりVEGF産生能に変化がないことから、長期間継続治療が可能であると考えられた。また、転移再発予防実験として、血管新生の亢進が起こり、その後に肝転移を起こす既報のモデルを用い、血管新生の亢進前と更新前に抗VEGF抗体を投与したところ、前に阻害した群で有意に肝転移を抑制することが判明した。以上より、抗VEGF抗体などの血管新生抑制剤は、VEGFが亢進する症例において、早い時期に継続治療することが最も効率的な投与になるものと考えられた。<br />I examined the effect of antibody to VEGF on two cell lines, KKLS and KM12sm : I have previously reported that VEGF upregulated in the orthotopic implantation of KKLS, and bFGF did in that of KM12sm. Antibody to VEGF inhibited the liver metastasis of KKLS, while did not that of KM12sm. Moreover, mRNA of other angiogenic factors such as bFGF did not upregulate in KKLS after therapy of antibody to VEGF therapy.From these results, it is suggested that antibody to VEGF should be given to the tumor whose VEGF upregulated and we can give it for a long time.<br />研究課題/領域番号:13671288, 研究期間(年度):2001 – 2002<br />出典:「抗VEGF抗体による血管新生治療の確立」研究成果報告書 課題番号1367128(KAKEN:科学研究費助成事業データベース(国立情報学研究所))(https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-13671288/136712882002kenkyu_seika_hokoku_gaiyo/)を加工して作成 続きを見る