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| 1.
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松尾, 信郎 ; Matsuo, Shinro
概要:
金沢大学附属病院核医学診療科<br />「短時間心筋SPECT/CTによる新しい診断技術の開発」については、虚血性心疾患またはその疑い症例に対して、低エネルギー性コリメータとSMARTZOOMコリメータを用いて心筋血流検査を行っ
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た。IQ-SPECTシステム短時間撮影による撮影で得られた解析の有用性が示された。「左室位相解析によるリスク層別化」は、位相解析を行って左室同期不全の指標を計測し、位相解析指標の規定因子についての解析が臨床応用できる。「N-13アンモニアによるリスク層別化研究」では、アンモニア合成装置を用いて、N-13アンモニアを合成し、TOF技術による虚血性心疾患の新しい診断技術が利用可能となる。<br />Regarding the development of a new diagnostic technique by myocardial SPECT / CT, Myocardial perfusion test was performed using SMARTZOOM collimator (IQ-SPECT) or low energy collimator. The results of IQ-SPECT system, obtained with short-time acquisition were compared with those of conventional shooting, and the analysis results were shown to be useful for clinical use. In the study "Risk stratification by left ventricular phase analysis", the index of left ventricular dyssynchrony was measured using phase analysis and QGS software which can evaluate left ventricular function. And the factors from phase analysis were validated in patients with coronary artery disease. In the research "Research on risk stratification by N-13 ammonia", N-13 ammonia was synthesized using ammonia synthesizer and the study was performed to develop a new diagnostic technique for ischemic heart disease by TOF technology.<br />研究課題/領域番号:26461846, 研究期間(年度):2014-04-01 - 2017-03-31
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| 2.
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小林, 正和 ; Kobayashi, Masato
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金沢大学医薬保健研究域附属健康増進科学センター<br />本研究では、最新型小動物用単光子放出断層撮像法における定量測定法を確立した。2種類の装置の性能評価を行った結果、ピンホールコリメータは、パラレルとスリッドと比較して感度が
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低下したが、高い空間分解能をもたらした。特に、eXplore speCZT CT120では半導体検出器を搭載しているためエネルギー分解能も優れていた。更に減弱と空間分解能補正法を組み合わせることで定量性もある程度確保できたが、マウス撮像では高分解能なコリメータ、ラット撮像では高感度用コリメータを新たに開発する必要性が生じた。その結果、マウス用では1.7倍の分解能となり、ラット用では2-3倍感度が向上し,定量性も確保されていた。<br />In this study, we developed a quantitative measurement on a new small animal SPECT/CT scanners with a semiconductor detecotor.After assessment of performance on the scanners,seinsitivity of pinhole collimators was lower than that of parallel and slit collimators, while resolution was higher. Especially, eXplore speCZT CT120 was superior to another scanner on energy resolution. In addition, attenuation and resolution correction have kept quaitification of radioactive counts.However, we needed to develop new pinhole collimators for mice to yield higher resolution and for rats to yield higher sensitivity. The collimators provided 1.7 times resoulution for mice imaging and 2-3 times sensitivity for rats imaging.<br />研究課題/領域番号:24601008, 研究期間(年度):2012-04-01 - 2015-03-31
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| 3.
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小野口, 昌久 ; Onoguchi, Masahisa
概要:
核医学画像はCTやMRIと異なり,画像を構築する技師(技術者)や医師の施設間差が大きく,施設間で診断が異なる場合も存在することから,心筋SPECT専用の画像精度管理と画像標準化を目的としたファントムおよび解析評価ツールの必要性が求められてい
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る。今回,開発したシステムの大きな特徴は心筋病変部の広さと深さを簡便に同時評価できる心筋ファントムの構築と画像の自動解析評価ツールの構築の2点であり,実用化に向けて必要なファントム作成技術および撮像システムの研究開発を試みた。<br />The goal of this study is to develop myocardial phantom EMIT (the evaluation system of myocardial image based on technical grounds) and analysis system toward standardization of myocardial SPECT image to reduce a difference of image quality among institutions. The construction of database criteria for quality of myocardial SPECTimage was possible. To be able to legally evaluate images of their own institutions using the database criteria, it was suggested that this myocardial phantom and analysis systemmay contribute to reduce a difference of image quality among institutions.<br />研究課題/領域番号:22591322, 研究期間(年度):2010-2012
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Shikano, Naoto ; Kawai, Keiichi ; Garcia Flores II, Leo ; Nishii, Ryuichi ; Kubota, Nobuo ; Ishikawa, Nobuyoshi ; Kubodera, Akiko
概要:
金沢大学大学院医学系研究科<br />We evaluated the use of radiolabeled 4-iodo-L-meta-tyrosine as an amino acid transport marker.
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The pharmacologic features of this compound, particularly the biodistribution and excretion, were examined by conducting in vivo and in vitro studies using 4-125I-iodo-L-meta-tyrosine (4- 125I-mTyr). Results obtained for L-14C-Tyr and 3- 125I-iodo-α-methyl-L-tyrosine (125I-IMT) were used for comparison. Methods: In vivo biodistribution studies of 4- 125I-mTyr were performed in male ddY mice. Urinary excretion of 4-125I-mTyr and 125I-IMT with administration of probenecid was studied. Local distribution of 4-125I-mTyr and 125I-IMT in kidney was visualized by autoradiography. We performed metabolite analysis of 4-125I-mTyr in mice. For in vitro studies, reabsorption mechanisms of 4-125I-mTyr were compared with those of 125I-IMT and the parent L-14C-Tyr using superconfluent monolayers of the porcine kidney epithelial cell line LLC-PK1 in medium containing inhibitor (L-Tyr, D-Tyr, and 2,4-dinitrophenol), in Na +-free medium, and at 4°C. Results: 4-125I-mTyr demonstrated high accumulation in the pancreas and kidney and comparable brain uptake to that of 125I-IMT. Blood clearance of 4-125I-mTyr was faster than that of 125I-IMT. Three hours after administration, >70% of 4-125I-mTyr was excreted via the urine, whereas <5% was found in the feces. Renal autoradiography revealed moderate accumulation of 4-125I-mTyr and high accumulation of 125I-IMT in the renal cortex. Probenecid further reduced accumulation of 4-125I-mTyr and 125I-IMT in the kidney as well as urinary excretion. At 30 min after tracer injection, intact free 4-125I-mTyr accounted for >98.1% of the total present in kidney and >96.3% in urine. Protein incorporation was not observed. Uptake of 4-125I-mTyr into LLC-PK1 cell monolayers was remarkably reduced by 5 mmol/L L-Tyr (4.6%) and incubation at 4°C (15.6%) but was reduced by 5 mmol/L D-Tyr (50.0%). L-14C-Tyr and 125I-IMT showed similar results; however, uptake of 125I-IMT was enhanced by 0.1 mmol/L 2,4-dinitrophenol (165.1%), an inhibitor of generation of energy-rich phosphates. Conclusion: The artificial amino acid 4-125I-mTyr demonstrated high metabolic stability, rapid blood clearance, rapid urinary excretion, and similar biodistribution to other radioiabeled L-Tyr analogs. 4-125I-mTyr can be a competitive substrate of L-Tyr reabsorption. However, 4-125I-mTyr demonstrates different pharmacologic features than those of 125I-IMT, particularly in renal handling. 4-125I-mTyr may potentially be applied as a new amino acid transport marker.
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Shuke, Noriyuki ; Okizaki, Atsutaka ; Kino, Shuichi ; Sato, Junichi ; Ishikawa, Yukio ; Zhao, Chunlei ; Kinuya, Seigo ; Watanabe, Naoto ; Yokoyama, Kunihiko ; Aburano, Tamio
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金沢大学大学院医学系研究科<br />The objective of this study was to validate a method for estimating regional liver asialoglycop
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rotein (ASGP) receptor amount from single blood samples using static SPECT with 99mTc-diethylenetriaminepentaacetic acid galactosyl human serum albumin (99mTc-GSA). Methods: Based on a 2-compartment nonlinear model, regional ASGP receptor amount could be calculated from total liver ASGP receptor amount (Ro) and regional GSA uptake at a specific time. Because Ro could be estimated from single blood samples using an empiric formula, regional GSA uptake obtained as a SPECT voxel count could be converted to regional ASGP receptor amount by solving a non-linear model equation. To validate this method, data from 62 patients with chronic liver disease underwent dynamic SPECT (30 rotations per 30 min) and simultaneous multiblood sampling and were analyzed by this method. Ro was calculated as the sum of voxel values of parametric receptor images generated from plasma concentration of GSA at 20 min and of static SPECT images generated by merging dynamic SPECT data (12-20 min). Ro was also estimated by fitting time-activity curves (4-30 min) of plasma and whole liver to the nonlinear model using the nonlinear regression method. Ro obtained from the receptor image was compared with that from curve fitting in relation to the results of hepatic function tests (indocyanine green test, hepaplastin test, and branched-chain amino acids/tyrosine plasma concentration ratio) and Child's classification. Results: Ros from the 2 methods showed a significant linear correlation (r2 = 0.938; P < 0.0001; slope = 0.90; y-intercept = 1.5). Both Ros had significant correlations with the results of hepatic function tests (P < 0.001) and differed significantly among the 3 groups of Child's classification (P < 0.0001). Conclusion: The present method could provide a quantitative ASGP receptor image without dynamic data acquisition. This approach could be useful for quantitative evaluation of regional liver function and estimation of residual liver function in hepatectomy.
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南部, 一郎
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小林, 真
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Taki, Junichi ; Matsunari, Ichiro
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金沢大学医学部附属病院核医学診療科<br />Introduction: In normal condition, the heart obtains more than two-thirds of its energy fro
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m the oxidative metabolism of long chain fatty acids, although a wide variety of substrates such as glucose, lactate, ketone bodies and amino acids are also utilised. In ischaemic myocardium, on the other hand, oxidative metabolism of free fatty acid is suppressed and anaerobic glucose metabolism plays a major role in residual oxidative metabolism. Therefore, metabolic imaging can be an important technique for the assessment of various cardiac diseases and conditions. Materials and methods: In SPECT, several iodinated fatty acid traces have been introduced and studied. Of these, 123I-labelled 15-(p-iodophenyl)3-R, S-methylpentadecanoic acid (BMIPP) has been the most commonly used tracer in clinical studies, especially in some of the European countries and Japan. Results and discussion: In this review article, several fatty acid tracers for SPECT are characterised, and the mechanism of uptake and clinical utility of BMIPP are discussed in detail. © 2007 Springer-Verlag.
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| 9.
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Matsuo, Shinro ; Nakajima, Kenichi ; Wakabayashi, Hiroshi ; Akhter, Nasima ; Taki, Junichi ; Okuda, Koichi ; Kinuya, Seigo
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金沢大学附属病院核医学診療科<br />Background: We evaluated the relationship between computed tomography angiography (CTA) and SP
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ECT, and assessed to determine the clinical usefulness of the fusion image using CTA and myocardial perfusion imaging (MPI). Methods: Forty-one consecutive patients [after coronary artery bypass operation (n = 13) and suspected stenosis (n = 28)] underwent MPI and CTA. SPECT/CTA fused images were generated. Results: In total, 687 segments including bypass graft in 164 coronary arteries were analyzed. Myocardial ischemia on MPI was observed in 11 patients among 28 with CTA abnormalities, one had both ischemia and infarction, and 7 had only infarction. Segment-based analysis showed that ischemia was found in 14 segments (24%) among 59 stenoses on CTA. Forty stenotic segments (69%) were not associated with perfusion abnormality. The rest 5 stenotic segments were considered equivocal (8%). A fusion image made it possible to associate perfusion defects with its corresponding coronary artery in 4 out of 5 equivocal lesions on side-by-side analysis. Patients with incremental diagnostic information on SPECT/CTA fusion (n = 4) had significant smaller coronary diameter than that of not-improved coronary vessels (2.0 ± 0.4 vs. 3.9 ± 0.4 mm, p = 0.001). Conclusion: Cardiac fusion imaging accurately diagnosed functionally relevant coronary stenosis. SPECT/CTA fusion images in coronary artery disease may provide added diagnostic information on functional relevance of coronary artery disease. © 2009 The Japanese Society of Nuclear Medicine.
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| 10.
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Matsuo, Shinro ; Nakajima, Kenichi ; Yamasaki, Yoshimitsu ; Kashiwagi, Atsunori ; Nishimura, Tsunehiko
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金沢大学附属病院核医学診療科<br />Background: This study was designed to determine the clinical risk for hard events after norma
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l single-photon emission computed tomography (SPECT) and to identify the predictors of increased risk in asymptomatic patients with diabetes mellitus, based on a Japanese Assessment of Cardiac Events and Survival Studies by quantitative gated SPECT (J-ACCESS)-2 study. Methods and Results: A total of 513 consecutive asymptomatic patients who underwent stress 99 mTc-tetrofosmin SPECT in Japan were included in this study. Based on SPECT image and QGS data, 319 had a summed stress score ≤3, a summed difference score <2 and normal cardiac function (end-systolic volume ≤60 ml, males, ≤40 ml, females; left ventricular ejection fraction ≥49%, males, ≥50%, females). Myocardial perfusion was normal in 62% of this study population. During a 3-year follow-up, there were a total of 8 cardiac major events (2.5%): 2 cases of sudden death, 5 of acute coronary syndrome, and 1 of hospitalization because of congestive heart failure. The annual major event rate was 0.8%. Subjects undergoing coronary angiography had significantly more major events than those who did not among normal SPECT subjects (P=0.01). Kaplan-Meier analysis showed that the cardiac major events rate was very low, and subjects with normal SPECT can be considered as low risk among asymptomatic patients with diabetes. Conclusions: An excellent prognosis was associated with a normal SPECT in asymptomatic patients with diabetes, so these patients can be exempted from further invasive procedure.
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