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論文

論文
Seok, Young Mi ; Azam, Mohammed Ali ; Okamoto, Yasuo ; Sato, Atsushi ; Yoshioka, Kazuaki ; Maeda, Masataka ; Kim, In Kyeom ; Takuwa, Yoh
出版情報: Hypertension.  56  pp.934-941,  2010-11-01.  American Heart Association
URL: http://hdl.handle.net/2297/25788
概要: 金沢大学医薬保健研究域医学系<br />Rho-mediated inhibition of myosin light chain (MLC) phosphatase (MLCP), together with Ca-depen dent MLC kinase activation, constitutes the major signaling mechanisms for vascular smooth muscle contraction. We recently unveiled the involvement of Ca-induced, phosphoinositide 3-kinase (PI3K) class IIα isoform (PI3K-C2α)-dependent Rho activation and resultant Rho kinase-dependent MLCP suppression in membrane depolarization- and receptor agonist-induced contraction. It is unknown whether Ca- and PI3K-C2α- dependent regulation of MLCP is altered in vascular smooth muscle of hypertensive animals and is involved in hypertension. Therefore, we studied the role of the Ca-PI3K-C2α-Rho-MLCP pathway in spontaneously hypertensive rats (SHRs). PI3K-C2α was readily detected in various vascular beds of Wistar-Kyoto rats and activated by high KCl. High KCl also stimulated vascular Rho activity and phosphorylation of the MLCP regulatory subunit MYPT1 at Thr in a PI3K inhibitor wortmannin-sensitive manner. In mesenteric and other vessels of SHRs at the hypertensive but not the prehypertensive stage, the activity of PI3K-C2α but not class I PI3K p110α was elevated with concomitant rises of Rho activity and Thr-phosphorylation of MYPT1, as compared with normotensive controls. Infusion of the Ca channel antagonist nicardipine reduced blood pressure with suppression of vascular activity of PI3K-C2α-Rho and phosphorylation of MYPT1 in hypertensive SHRs. Infusion of wortmannin lowered blood pressure with inhibition of PI3K-C2α-Rho activities and MYPT1 phosphorylation in hypertensive SHRs. These observations suggest that an increased activity of the Ca-PI3K-C2α-Rho signaling pathway with resultant augmented MLCP suppression contributes to hypertension in SHRs. The Ca- and PI3K-C2α-dependent Rho stimulation in vascular smooth muscle may be a novel, promising target for treating hypertension. © 2010 American Heart Association, Inc. 続きを見る
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論文

論文
林, 浩孝 ; 大野, 智 ; 橋本, 慎太郎 ; 新井, 隆成 ; 鈴木, 信孝
出版情報: 日本補完代替医療学会誌 = Japanese journal of complementary and alternative medicine.  5  pp.37-47,  2008-01-01.  日本補完代替医療学会 = The Japanese Society for Complementary and Alternative Medicine
URL: http://hdl.handle.net/2297/28432
概要: 「特定保健用食品」のうち,生活習慣病の 1 つである高血圧に関連して「血圧が高めの方に適する」表示をした食品については,現在のところ,再許可等特定保健用食品を含め約 90 種類の商品がある.そのうちのいくつかについて,安全性・有効性について 解説する. Of “foods for specified health use (FOSHU)”, approximately 90 kinds are presently indicated as “appropriate for hypertension”. In this review we describe their safety and effectiveness. 続きを見る
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論文

論文
大桑, 仁
出版情報: 金沢大学十全医学会雑誌.  100  pp.615-631,  1991-08-20.  金沢大学十全医学会
URL: http://hdl.handle.net/2297/8284