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論文
Nakajima, Kenichi ; Takeishi, Yasuchika ; Matsuo, Shinro ; Yamasaki, Yoshimitsu ; Nishimura, Tsunehiko
出版情報: Journal of Nuclear Cardiology.  20  pp.234-241,  2013-04-01.  American Society of Nuclear Cardiology (ASNC) / Springer Verlag (Germany)
URL: http://hdl.handle.net/2297/33408
概要: Purpose: Patients with metabolic syndrome (MetS) have potentially higher risk for cardiovascular events. The aim of this study was to evaluate the effect of MetS on cardiac events in type-2 diabetic patients asymptomatic for coronary artery disease (CAD) in a Japanese population. Methods: A total of 485 patients from a J-ACCESS-2 investigation with stress-gated myocardial perfusion imaging (MPI) and quantitative-gated MPI analysis were examined. Cardiovascular hard events (cardiac death and acute coronary syndrome) and total events during a 3-year follow-up were analyzed. Results: The MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256). The hard events were 8 and 12 for the MetS and non-MetS groups (P = n.s.), and total events were 31 and 31 for each of these groups, respectively (P = n.s.). Significant variables related to total cardiovascular events included age, current smoking, insulin use, total cholesterol, ejection fraction, summed stress score ≥ 9, and summed difference score ≥ 2. Cox proportional hazard analysis and Kaplan-Meier survival analysis showed that only the summed stress score was related to total events (P = .01), and the presence and the number of items for MetS criteria were not. Conclusion: In patients with type 2 diabetes asymptomatic for CAD, cardiovascular events and ischemia are as common in diabetic patients without MetS as in those with MetS. A high MPI defect score is related to total events including cardiac and cerebrovascular events. © 2012 American Society of Nuclear Cardiology. 続きを見る
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論文
柏原, 謙悟 ; 山嶋, 哲盛 ; 新多, 寿 ; 早瀬, 秀男 ; 伊藤, 治英 ; 山本, 信二郎
出版情報: Neurologia medico-chirurgica = 神経外科.  26  pp.689-694,  1986-01-01.  日本脳神経外科学会 = The Japan Neurosurgical Society
URL: http://hdl.handle.net/2297/40415
概要: 564 patients with subarachnoid hemorrhage caused by ruptured cerebral aneurysm were studied statistically with a correlation between retinal hemorrhage (RH) and outcome. Of these, 142 patients (or 25%) exhibited RH. No correlation was demonstrated between the frequency of RH and age or sex. Unilateral RH was seen in 34 patients with middle cerebral artery or internal carotid artery aneurysm and out of them, 25 patients (or 74%) had RH in the aneurysm side. The mortality rate of the patients with RH was 35% which is higher than that of patients without RH (13%). Of the 93 survivors with RH, 68 patients (or 73%) required daily-care. In contrast, out of 367 survivors without RH, 124 patients (or 34%) required daily-care. There was a significant correlation between the severity of RH and survival rate or activities of daily living, although there was no difference in the outcome between the patients with unilateral and bilateral RH. There were 15 cases (or 2.7%) with Terson's syndrome (TS). The mortality rate of patients with TS was 20% and all of the 12 survivors required daily-care. It is concluded that ruptured cerebral aneurysms with RH show a poorer prognosis than those without RH. 続きを見る
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七島, 篤志   ; 角田, 順久   ; 木下, 直江   ; 澤井, 照光  ; 阿保, 貴章  ; 飛永, 修一 ; 林, 徳真吉  ; 永安, 武   ; 中沼, 安二
出版情報: 消化器科 = Digestive medicine.  47  pp.303-311,  2008-01-01.  科学評論社
URL: http://hdl.handle.net/2297/29618
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論文
牧田, 治朗
出版情報: 金沢大学十全医学会雑誌.  96  pp.756-772,  1987-08-20.  金沢大学十全医学会
URL: http://hdl.handle.net/2297/7968
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山田, 善夫
出版情報: 金沢大学十全医学会雑誌.  94  pp.311-328,  1985-04-20.  金沢大学十全医学会
URL: http://hdl.handle.net/2297/7783
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論文
岡宗, 絢子
出版情報: 金沢大学十全医学会雑誌 = Journal of the Jûzen Medical Society.  120  pp.138-147,  2011-12-01.  金沢大学十全医学会 = The Juzen Medical Society Kanazawa University
URL: http://hdl.handle.net/2297/30240
概要: [原著] [Originals] / 平成23年11月2日受付, 平成23年12月7日受理
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丸山, 裕美子
出版情報: 金沢大学十全医学会雑誌.  107  pp.64-73,  1998-02-20.  金沢大学十全医学会
URL: http://hdl.handle.net/2297/9279
概要: 金沢大学医学部医学科
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論文
Nakajima, Kenichi ; Nakata, Tomoaki
出版情報: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.  56  pp.11S-19S,  2015-06-01.  Society of Nuclear Medicine
URL: http://hdl.handle.net/2297/43645
概要: Cardiac neuroimaging with (123)I-metaiodobenzylguanidine ((123)I-MIBG) has been officially used in clinical practice in Japan since 1992. The nuclear cardiology guidelines of the Japanese Circulation Society, revised in 2010, recommended cardiac (123)I-MIBG imaging for the management of heart failure (HF) patients, particularly for the assessment of HF severity and prognosis of HF patients. Consensus in North American and European countries regarding incorporation into clinical practice, however, has not been established yet. This article summarizes 22 y of clinical applications in Japan of (123)I-MIBG imaging in the field of cardiology; these applications are reflected in cardiology guidelines, including recent methodologic advances. A standardized cardiac (123)I-MIBG parameter, the heart-to-mediastinum ratio (HMR), is the basis for clinical decision making and enables common use of parameters beyond differences in institutions and studies. Several clinical studies unanimously demonstrated its potent independent roles in prognosis evaluation and risk stratification irrespective of HF etiologies. An HMR of less than 1.6-1.8 and an accelerated washout rate are recognized as high-risk indicators of pump failure death, sudden cardiac death, and fatal arrhythmias and have independent and incremental prognostic values together with known clinical variables, such as left ventricular ejection fraction and brain natriuretic peptide. Another possible use of this imaging technique is the selection of therapeutic strategy, such as pharmacologic treatment and nonpharmacologic treatment with an implantable cardioverter-defibrillator or cardiac resynchronization device; however, this possibility remains to be investigated. Recent multiple-cohort database analyses definitively demonstrated that patients who were at low risk for lethal events and who were defined by an HMR of greater than 2.0 on (123)I-MIBG studies had a good long-term prognosis. Future investigations of cardiac (123)I-MIBG imaging will contribute to better risk stratification of low-risk and high-risk populations, to the establishment of cost-effective use of this imaging technique for the management of HF patients, and to worldwide acceptance of this imaging technique in clinical cardiology practice. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc. 続きを見る
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Hara, Akinori ; Furuichi, Kengo ; Koshino, Akihiko ; Yasuda, Haruka ; Tran, Trang Thi Thu ; Iwata, Yasunori ; Sakai, Norihiko ; Shimizu, Miho ; Kaneko, Shuichi ; Nakamura, Hiroyuki ; Wada, Takashi ; 原, 章規 ; 古市, 賢吾 ; 岩田, 恭宜 ; 坂井, 宣彦 ; 清水, 美保 ; 金子, 周一 ; 中村, 裕之 ; 和田, 隆志
出版情報: Kidney International Reports.  3  pp.133-141,  2018-01-01.  Elsevier Inc
URL: http://hdl.handle.net/2297/00050598
概要: 金沢大学医薬保健研究域医学系<br />Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) i n type 2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diabetes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology<br />Embargo Period 12 months 続きを見る
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論文
太田, 安彦 ; 清水, 洋介 ; 加藤, 陽介 ; 松本, 勲 ; 田村, 昌也 ; 小田, 誠 ; 湊, 宏 ; 渡辺, 剛 ; Ohta, Yasuhiko ; Shimizu, Yosuke ; Kato, Yosuke ; Matsumoto, Isao ; Tamura, Masaya ; Oda, Makoto ; Minato, Hiroshi ; Watanabe, Go
出版情報: 胸部外科 = 日本心臓血管外科学会雑誌 = The Japanese journal of thoracic surgery.  58  pp.949-953,  2005-10.  日本心臓血管外科学会 = The Japanese Society for Cardiovascular Surgery / 南江堂
URL: http://hdl.handle.net/2297/00051076
概要: 金沢大学医薬保健研究域医学系<br />This retrospective analysis was undertaken to review our results of treatment of lung cancers with invasion of non-apical and non-vertebral chest wall structures. In summary of our experience, although relatively good prognosis can be expected in N0M0 patients with the histological type of adenocarcinoma by initial operation, distant relapse remains a major problem of the disease. Furthermore, our results are in agreement with the idea that postoperative adjuvant therapy is of little value in patients with complete resection. To ameliorate surgical outcomes, induction treatment should be considered and preoperative staging assessment needs to be strictly done for proper selection of patients with this locally advanced disease. The indication of initial operation needs to be cautiously determined for patients with this disease. 続きを見る