※一部利用できない機能があります
1.
論文 |
柳下, 信一
|
|||||
2.
論文 |
茶谷, 修平
概要:
金沢大学医学部医学科
|
|||||
3.
論文 |
野村, 素弘
|
|||||
4.
論文 |
4. Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity
Oshima, Masanobu ; Suzki, Hiromi ; Guo, Xiaoying ; Oshima, Hiroko
概要:
We have previously demonstrated that short-term exposure to hypergravity at 2G for 4 h induces expression of cyclooxygenase-2 (COX-2) in the mouse heart. Moreover, expression of vascular endothelial growth factor (VEGF) is also
…
induced in the heart in a COX-2-dependent manner. Here, we demonstrate that long-term exposure of mice to 2G for 24 h resulted in a significant increase of serum VEGF level, although expression of COX-2 and VEGF in the heart decreased to the 1G-control level. Moreover, increase of serum VEGF was not suppressed by treatment with COX-2 inhibitor, indicating that VEGF was induced in a COX-2-independent manner. These results suggest that gravitational force contributes to maintenance of the serum VEGF level.
続きを見る
|