全自動ELISAシステムによるゾニサミドおよびハロペリドールの血漿中濃度測定

フォーマット:

論文

責任表示:

石崎, 純子 ; 横川, 弘一 ; 中島, 恵美 ; 古田, 壽一 ; 越野, 好文 ; 関, 秀俊 ; 谷口, 昂 ; 長谷川, 光広 ; 山下, 純宏 ; 市村, 藤雄

言語:

日本語

出版情報:

日本医療薬学会, 1997-08-10

著者名:

石崎, 純子

横川, 弘一

中島, 恵美

古田, 壽一

越野, 好文

関, 秀俊

谷口, 昂

長谷川, 光広

山下, 純宏

市村, 藤雄

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掲載情報:

病院薬学

ISSN:

0389-9098      

巻:

23

通号:

4

開始ページ:

358

終了ページ:

363

バージョン:

publisher

概要:

金沢大学大学院自然科学研究科分子作用学<br />金沢大学医学部附属病院薬剤部<br />金沢大学大学院医学系研究科<br />A fully automated enzyme immunoassay system, Omni (BIO-TEK Co.) (ELISA system), using Markit-M Excegran and Markit-M Haloperidol (Dainippon Pharmaceutical Co. … ) was evaluated to determine the concentrations of zonisamide (ZNS) and haloperidol (HP) in human plasma. At first, the within-run (ZNS : n=8, HP : n=10) and the between-run (4 days) precisions of ZNS and HP were examined. The coefficient of the variations in both the within-run and the between-run previsions of HP were below 5.0 and 7.00/0, respectively. In contrast, the some values of ZNS were below 6.5 and 8.40/0, respectively. A good correlation was observed between this ELISA system and HPLC (r=0.917), which was used to determine the plasma ZNS concentration. In the case of HP, a good correlation was seen between this ELISA system and the manual ELISA method (r=0.978). This method was thus used to monitor the serum levels in patients receiving ZNS or HP therapy. The relationship was observed between the daily dose (mg/kg) and the plasma concentration of the trough level for ZNS and HP, respectively (r=0.750 p<0.001, r= 0.669 p<0.001). However, the ratio of the plasma concentration of ZNS and the daily dose increased significantly with aging. 続きを見る

URL:

http://hdl.handle.net/2297/6254