1.

図書

図書
Kazuichi Hayakawa ... [et al.], editors
出版情報: New York : Nova Science Publishers, c2018
シリーズ名: Environmental research advances series
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2.

図書

図書
Kazuichi Hayakawa, editor
出版情報: Singapore : Springer, c2018
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3.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2005.3
シリーズ名: 科学研究費補助金(基盤研究(B)(2))研究成果報告書 ; 平成15年度~平成16年度
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4.

図書

図書
田崎和江・早川和一(編著)
出版情報: 金沢 : 金沢大学21世紀COEプログラム, 2006.12
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図書
editorial supervisor, Kazuichi Hayakawa ; editors, Ning Tang ... [et al.]
出版情報: Tokyo : Maruzen, c2006
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図書
早川, 和一 ; 木津, 良一(1955-) ; 鎌田, 直人(1962-)
出版情報: Kanazawa : Kanazawa University, c2004
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7.

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宮崎元一,早川和一共著
出版情報: 東京 : 南江堂, 1986.10
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8.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2004.3
シリーズ名: 科学研究費補助金(基盤研究(B)(2))研究成果報告書 ; 平成14年度~15年度
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9.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2001.3
シリーズ名: 科学研究費補助金(基盤研究(B)(1))研究成果報告 ; 平成10年度〜12年度
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10.

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図書
中島憲一郎, 早川和一編
出版情報: 東京 : 南山堂, 2000.1
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11.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1998.3
シリーズ名: 科学研究費補助金基盤研究(C)(2)研究成果報告書 ; 平成8〜9年度
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12.

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図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1992.3
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13.

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研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1996.3
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研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1996.3
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15.

論文

論文
小村, 和久 ; 稲垣, 美幸 ; 西川, 方敏 ; 中西, 孝 ; 早川, 和一 ; 唐, 寧 ; 楊, 小陽 ; 飯田, 孝夫 ; 森泉, 純 ; Komura, Kazuhisa ; Inagaki, Miyuki ; Nishikawa, Katatoshi ; Hayakawa, Kazuichi ; Tang, Ning ; Yang, Xiaoyang ; Iida, Takao ; Moriizumi, Jyun
出版情報: 地球科学 = Earth Science.  61  pp.335-342,  2007-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00063583
概要: 金沢大学環日本海域環境研究センター<br />Variations of radiation levels before and after the Noto Hanto Earthquake in 2007 have been analy zed from the point of view of environmental radioactivity. The 210Pb activities in the airborne particles are collected from Nishi-Futamata in Wajima, are analyzed. The Radon activity at Hegura Island located 50km North of Wajima, and the spatial gamma rays at Nishi-Futamata are measured since April 21, 2007. Abnormal increase of 210Pb activity started 3 weeks before the earthquake are found, suggesting the maximum value just before the earthquake, because it decrease to normal level after 2 weeks. Increase of radon level was not observed at Hegura Island, however, increase of radiation level at Nishi-Futamata area continued for 6 weeks after the earthquake, and settled to normal level in middle of May 2007.<br />環境放射能の観点から能登半島地震発生前後の放射能関連のデータの解析を試みた.解析したのは,輪島市西二又地区で採取した大気浮遊塵中の210Pb,輪島沖50kmに位置する舳倉島のラドン濃度,地震発生後の4月21日から西二又地区で連続測定を実施した空間γ線レベルの3項目である.その結果,地震発生約3週間前から大気浮遊塵試料のラドンの娘核種210Pbの濃度が増加し,地震直前にピークに達した後に低下に転じ,約2週間後にほぼ平常値に回復していたことが分かった.舳倉島のラドンには地震の影響は見られなかったが,西二又における空間γ線レベルはラドンに由来すると考えれる高い値が約6週間後も続き5月中頃に平常値に戻ったことが明らかになった. 続きを見る
16.

論文

論文
Hayakawa, Kazuichi ; Miyoshi, Yasuko ; Kurimoto, Hiroaki ; Matzushima, Yuko ; Takayama, Nariaki ; Tanaka, Seishi ; Miyazaki, Motoichi ; 早川, 和一 ; 三好, 裕子 ; 栗本, 博昭 ; 松島, 優子 ; 高山, 成明 ; 田中, 星司 ; 宮崎, 元一
出版情報: Biological and Pharmaceutical Bulletin.  16  pp.817-821,  1993-09-15.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063584
概要: 金沢大学理工研究域自然システム学系<br />A HPLC determination method for methamphetamine (MA) and its metabolites in the urine samples of abusers has been developed. MA, amphetamine (AP), norephedrine (NE), p-hydroxymethamphetamine (pOHMA), p-hydoroxyamphetamine (pOHAP) and an internal standard, namely β-phenylethylamine (PEA) were derivatized with dansyl chloride. They were separated on a reversed phase column with gradient elution using an acetonitrile/tetrahydrofuran/imidazole buffer mobile phase and chemilumigenically determined using bis(2, 4, 6-trichlorophenyl)-oxalate/hydrogen peroxide as post column reagents. The lower determination limits were as low as 1×10-14-3×10-14mol. AP, NE, pOHAP and PEA were derivatized with naphthalene-2, 3-dicarboxaldehyde, and were separated on a reversed phase column using an acetonitrile/imidazole buffer mobile phase and chemilumigenically determined. The lower determination limits were 3×10-16-1.5×10-15mol. Enzymatic hydrolysis of glucuronides of pOHMA (pOHMAG) and pOHAP (pOHAPG) allowed them to be determined as pOHMA and pOHAP, respectively. After adjusting the pH of the urine samples to 10.5 and adding PEA, all metabolites except glucuronides were extracted quantitatively into chloroform-isopropanol (3 : 1). Utilizing the two methods, MA and all metabolites were determined in urine samples of MA abusers. The tendency, in order of decreasing concentration was : [MA]>[A]>[pOHMAG]>[pOHMA]>[NE]>[pOHAPG]>[pOHAP]. Although ephedrine (EP) was detected in several samples, it was not considered to be a metabolite of MA but rather a component derived from cough medicine. 続きを見る
17.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  45  pp.797-801,  2009-08-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063588
概要: 金沢大学理工研究域自然システム学系
18.

論文

論文
山本, 敦 ; 早川, 和一 ; Yamamoto, Atsushi ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  34  pp.34-38,  1998-01-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063589
概要: 金沢大学理工研究域自然システム学系
19.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  40  pp.195-197,  2004-03-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063590
概要: 金沢大学理工研究域自然システム学系
20.

論文

論文
後藤, 純雄 ; 峯木, 茂 ; 杉田, 和俊 ; 遠藤, 治 ; 村山, 留美子 ; 内山, 巌雄 ; 田中, 基裕 ; 早川, 和一 ; Goto, Sumio ; Mineki, Shigeru ; Sugita, Kazutoshi ; Endo, Osamu ; Murayama, Rumiko ; Uchiyama, Iwao ; Tanaka, Motohiro ; Hayakawa, Kazuichi
出版情報: 環境化学 = Journal of Environmental Chemistry.  7  pp.553-559,  1997-09-12.  環境化学研究会 Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/00063597
概要: 金沢大学理工研究域自然システム学系<br />ナホトカ号から流出し日本海沿岸に漂着した重油の汚染状況を把握するための調査研究の一環として, 平成9年1月16日に採取した漂着重油, ナホトカ号船首部分の重油および市販C重油中に含まれる多環芳香 族炭化水素 (PAH) の分析及び抽出物の変異原性を測定した。その結果, 漂着重油のベンゾ (a) ピレン (BaP) 含有量は1984年に採取された東京都市部の土砂51試料の平均値の約1/4であることやその変異原比活性は同土砂の約4倍であることなどを認めた。<br />As a part of research studies on the pollution at heavy-oil coated parts of the Sea of Japan coastline, resulting from the wrecked Russian tanker Nakhodka on Jan. 2, the following experiments were performed using three heavy oil samples. Polycyclic aromatic hydrocarbons (PAH) were analyzed by HPLC in the heavy oil that washed ashore, which was collected at Mikuni-cho in Fukui Prefecture on Jan. 16, 1997, heavy oil in the oil compartment of the bow of the tanker, and commercial heavy oil (class C) .Mutagenicities of the extracts of these oil samples were also measured. The amount of benzo (a) pyrene (BaP) contained in the heavy oil that washed ashore was about a quarter of the average in 51 soil extracted samples, which were collected at an urban area in Tokyo in 1984, and mutagenicity of the extract from the oil was about 4-fold higher than the average in the extracts from the soil samples. 続きを見る
21.

論文

論文
佐川, 岳人 ; 西, 香菜子 ; 納富, 美穂 ; 平岡, 龍之 ; 塚本, 和巳 ; 早川, 和一 ; Sagawa, Takehito ; Nishi, Kanako ; Notomi, Miho ; Hiraoka, Tatsuyuki ; Tsukamoto, Kazumi ; Hayakawa, Kazuichi
出版情報: 日本食品科学工学会誌 = Nippon Shokuhin Kagaku Kogaku Kaishi.  58  pp.222-228,  2011-05-15.  日本食品科学工学会 Journal of the Japanese Society for Food Science and Technology
URL: http://hdl.handle.net/2297/00063602
概要: 金沢大学理工研究域自然システム学系<br />生スィートバジルを乾燥する際に引き起こされる香りの変化を,香気成分バランスやスィートバジルの組織構造とそのレオロジー特性について,比較解析を行う事で,生スィートバジルの香りを維持する為に必要とさ れる因子の探索を行った.スィートバジルの香気寄与成分として特定したシネオール,リナロール,オイゲノール,オクタナール,1-オクタノール,(E)-2-ヘキセナール,(Z)-3-ヘキセノールの7種類の香気成分は官能評価の特徴を説明する因子となると考えられる.その中でも,生スィートバジルの香りを特徴づける因子としては,微量成分バランスが大きな役割を果たし,ハーブ自体には (E)-2ヘキセナールや (Z)-3-ヘキセノールが存在するが,それがハーブティーに溶出されずオクタナールが高い比率で溶出されることが重要であった.そのような性質を持つ組織構造は,葉内部の細胞壁の形状が乾燥工程を経ても維持されており,その状態は貯蔵弾性率の測定でも比較説明が可能であることが明らかになった.これらの結果により,ハーブの組織構造とハーブティーとして溶出される香気成分バランスに密接な関係がある可能性が示唆された.但し,今回確認された (E)-2-ヘキセナールや (Z)-3-ヘキセノールはみどりの香りと称される物質の1つである.これらの物質は植物中のリノレン酸や配糖体を前駆体として酵素が関与し発現するものであり12),食品加工時に発生することも知られている14)~16) .今後は配糖体量の変化と酵素の関係についても検討を行い,組織構造変化の香りに対する影響をより明確にしてゆく必要があると考える.しかしながら,細胞壁の損傷が少ない状態であった真空乾燥スィートバジルが生特有の香りを保持していたという事実から,乾燥工程を経ることで喫食時に感じる香りの違いは,単純な香気成分の増減という因子だけではなく,組織構造変化という因子からも説明できる可能性が示唆された.乾燥ハーブの香りに対する品質評価を行う上で,乾燥ハーブからハーブティーに抽出されてゆく香気成分のバランス変化や内部組織構造変化の比較といった多面的なアプローチは,今後の有効な評価手法の1つとなることが期待できる.<br />A quality evaluation method for dried herbs was studied with sweet basil leaves (fresh, air-dried, freeze-dried and vacuum-dried sweet basil leaves) as herbal teas, involving hot-water extraction. Sensory evaluation revealed that the flavor of herbal tea with vacuum-dried sweet basil leaves was similar to that with fresh leaves. Seven odor-active compounds (cineole, linalool, eugenol, octanal, 1-octanol, (E)-2-hexenal and (Z)-3-hexenol) from herbal teas were identified by capillary gas chromatographic-mass spectrometry and olfactometry analysis, and it was considered that three compounds (octanal, (E)-2-hexenal and (Z)-3-hexenol) were key compounds for describing the results of sensory evaluation. The structure of dried sweet basil leaves with water-absorption and fresh leaves was observed by differential interference contact microscopy, and their rheological characteristics were measured for storage modulus. As a result, the characteristics of vacuum-dried sweet basil were similar to those of fresh basil. These results suggest that investigation of the aroma using hot-water extraction, tissue structure and rheological characteristics could be effective approaches to qualitatively evaluate dried herbs. 続きを見る
22.

論文

論文
神山, 和夫 ; 小池, 益人 ; 平尾, 宜司 ; 鳥羽, 陽 ; 早川, 和一 ; Koyama, Kazuo ; Koike, Masuhito ; Hirao, Takashi ; Toriba, Akira ; Hayakawa, Kazuichi
出版情報: 日本食品工学会誌 = Japan Journal of Food Engineering.  13  pp.43-49,  2012-09-15.  日本食品工学会 Japan Society for Food Engineering
URL: http://hdl.handle.net/2297/00063603
概要: 金沢大学理工研究域自然システム学系<br />製造工程中に起きるデンプンの部分糊化が,レトルトカレーの最終粘度に及ぼす影響を調べた.レトルトカレーの粘度は,煮込みとそれに続くレトルト殺菌工程で,原料中のデンプンが糊化することで上昇する.しか し,煮込み工程前の原料混合工程の温度が高過ぎると,最終粘度が十分に上昇しないことが経験的にわかっている.そこで,原料混合工程の温度とデンプンの糊化状態をアミロース溶出度,膨潤度,動的粘弾性および示差走査熱量分析から調べ,最終粘度との関係を考察した.その結果,原料混合工程の温度が65℃以上であると,デンプンの部分糊化が起こるため,その後の煮込み工程と殺菌工程での粘度上昇は抑制されることがわかった.<br />The effect of partial gelatinization of starch during precooking operation on the final viscosity of retort curry at serving temperature was investigated. While the increase in the viscosity of retort curry is largely due to the starch gelatinization during the heating processes of cooking and sterilization, it is known empirically that a high temperature during the material mixing operation before cooking may result in a lower final viscosity. The relationship between the temperature and the partial starch gelatinization during material mixing was therefore studied by measuring amylose leaching, swelling ratio, dynamic viscoelasticity, and by differential scanning calorimetry (DSC). When the mixing temperature was at or higher than 65℃, the starch was partially gelatinized under the low water condition, and as the result, the increase in the viscosity during cooking and sterilization was suppressed. This finding is expected to be useful in controlling the viscosity of starch-containing retort foods. 続きを見る
23.

論文

論文
鳥羽, 陽 ; 笠原, 千栄子 ; 戸次, 加奈江 ; 佐溝, 将之 ; 唐, 寧 ; 早川, 和一 ; Toriba, Akira ; Kasahara, Chieko ; Bekki, Kanae ; Samizo, Masayuki ; Ning, Tang ; Hayakawa, Kazuichi
出版情報: 分析化学 = BUNSEKI KAGAKU.  68  pp.839-845,  2019-11-05.  日本分析化学会 The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/00063604
概要: 金沢大学理工研究域自然システム学系<br />大気中の粒子状物質(PM)中の水酸化多環芳香族炭化水素(OHPAH)を定量することを目的とするGC/MSによる分析法を開発した.母核の環数が2〜4環のOHPAH 10種を分析対象とし,トリメチル シリル(TMS)誘導体化したうえで検出し,3種類の重水素化,または安定同位体標識化OHPAHを内部標準物質として用いてPM試料の定量に適用した.OHPAHのTMS誘導体の選択イオン検出(SIM)における検出限界(S/N=3)は,12〜930 fgの範囲で,すべての分析対象物質について10.5分で分離・検出することができた.都市大気標準粉じんや金沢で捕集したPM試料はジクロロメタンで抽出したのち,シリカゲル固相により精製しTMS誘導体化して定量した.金沢で捕集したPM試料中の8種のOHPAHを定量することに成功し,それらの濃度範囲は,20〜4100 fg m−3であり,3-hydroxyfluorantheneのPM中濃度の報告は本研究が初めてである.確立した分析法は,大気粉じん中のOHPAHを定量する際の分析法の選択肢の一つとして有用である.<br />A GC/MS method was developed for the quantification of hydroxylated polycyclic aromatic hydrocarbons (OHPAHs) in airborne particulate matter (PM). Ten OHPAHs having 2 - 4 rings were detected after trimethylsilyl (TMS) derivatization, and the derivatives in PM samples were quantified with three kinds of deuterated or stable isotope labeled OHPAHs as internal standards. The detection limits (S/N = 3) of the derivatives of OHPAHs in the selected ion monitoring (SIM) mode ranged from 12 to 930 fg and all analytes were separated and detected within 10.5 min. A commercially available urban PM sample and PM samples collected in Kanazawa were extracted with dichloromethane, and then the extracts were purified with silica gel solid phase and derivatized OHPAHs in the extracts were quantified. We successfully quantified 8 OHPAHs in PM samples collected in Kanazawa, and their concentrations were in the range of 20 - 4100 fg m−3 and the levels of 3-hydroxyfluoranthene were reported for the first time. This method should be useful as an optional analytical method to quantify OHPAHs in PM samples. 続きを見る
24.

論文

論文
Bekki, Kanae ; Toriba, Akira ; Ning, Tang ; Kameda, Takayuki ; Hayakawa, Kazuichi ; 戸次, 加奈江 ; 鳥羽, 陽 ; 唐, 寧 ; 亀田, 貴之 ; 早川, 和一
出版情報: Journal of UOEH = 産業医科大学雑誌.  35  pp.17-24,  2013-03-01.  産業医科大学 University of Occupational and Environmental Health
URL: http://hdl.handle.net/2297/00063611
概要: 金沢大学理工研究域自然システム学系<br />Polycyclic aromatic hydrocarbons (PAHs) are included in various environmental pollutants such as airborne particles and have been reported to induce a variety of toxic effects. On the other hand, PAH derivatives are generated from PAHs both through chemical reaction in the atmosphere and metabolism in the body.PAH derivatives have become known for their specific toxicities such as estrogenic/antiestrogenic activities and oxidative stress, and correlations between the toxicities and structures of PAH derivatives have been shown in recent studies. These studies are indispensable for demonstrating the health effects of PAH derivatives, since they would contribute to the comprehensive toxicity prediction of many kinds of PAH derivatives.<br />多環芳香族炭化水素類(PAHs)は大気粉塵などの多種類の環境汚染物質に含まれ,長年の研究によって多様な生体影響を引き起こすことが知られている.一方で,PAHsは生体内での代謝反応や,大気中での化学反応によって多種多様な誘導体を生成することが知られている.近年では,PAHだけでなくPAH誘導体の毒性影響が着目されており,エストロゲン様/抗エストロゲン作用,酸化ストレス反応など,PAHとは異なる誘導体独自の毒性影響の存在が報告されている.また,生成するPAH誘導体には多くの構造異性体が存在するが,PAH誘導体が示す毒性作用と構造との間に相関性,いわゆる構造活性相関があることが示されている.以上の研究は,環境中に存在するPAH 誘導体の生体影響を解明する上で重要な研究であるとともに,多種多様なPAH誘導体の総合的な毒性影響予測に貢献できると考えられる. 続きを見る
25.

論文

論文
中澤, 章 ; 唐, 寧 ; 井上, 嘉則 ; 上茶谷, 若 ; 加藤, 敏文 ; 齊藤, 満 ; 小原, 健嗣 ; 鳥羽, 陽 ; 早川, 和一 ; Nakazawa, Akira ; Ning, Tang ; Inoue, Yoshinori ; Kamachitani, Waka ; Katoh, Toshifumi ; Saito, Mitsuru ; Obara, Kenji ; Toriba, Akira ; Hayakawa, Kazuichi
出版情報: Journal of UOEH = 産業医科大学雑誌.  39  pp.69-74,  2017-03-01.  産業医科大学 University of Occupational and Environmental Health
URL: http://hdl.handle.net/2297/00063612
概要: 金沢大学理工研究域自然システム学系<br />著者らが開発した繊維状吸着材(DAM不織布)は,両性イオン型高分子であるジアリルアミン‐マレイン酸共重合体(diallylamine-maleic acid copolymer: DAM)を含有 し,繊維表面に水和層を形成する.本研究では,悪臭物質の一つである半揮発性有機酸(C1-C5)を対象に水溶液だけでなくガス状でもDAM不織布の吸着特性評価を行った.まず,水溶液中のギ酸はDAM不織布の水和層へ溶解した後,DAMのイミノ基との静電相互作用で吸着することがわかった.一方ガス状では,ギ酸,プロピオン酸,酪酸,吉草酸,イソ吉草酸について高い吸着能を有し,吸着量は曝露時間に依存して増加する傾向があった.ガス状有機酸に対する吸着も水溶液と同様の機序で生じていると考えられるが,さらに酢酸を除く有機酸の吸着速度定数と空気 / 水分配係数(log Kaw)が良好な相関性を有したことから,DAM不織布は大気中から不織布表面に形成される水和層へ移行性が高い親水性化合物に対するほど高い選択性をもつことが示された.<br />Diallylamine-maleic acid copolymer (DAM)-nonwoven fabric (DAM-f), a fibrous adsorbent, contains DAM with zwitter-ionic functional groups and forms a hydration layer on the surface. The aim of this report was to evaluate the adsorption selectivity of DAM-f to semi-volatile organic acid (C1-C5). In the aqueous phase, formic acid dissolved in the hydration layer bound to the imino group of DAM-f due to anion exchange interaction. In the gas phase, the adsorption amounts of organic acids increased with the exposure time. Moreover, the adsorption rate constants correlated with the air/water partition coefficients (log Kaw) for formic acid, propionic acid, butyric acid, valeric acid and isovaleric acid, except for acetic acid. These results indicate that DAM-f is highly selective to hydrophilic compounds which easily move from the air to the hydration layer of DAM-f. 続きを見る
26.

論文

論文
早川, 和一 ; 加賀谷, 重浩 ; Hayakawa, Kazuichi
出版情報: ぶんせき.  456  pp.724-726,  2012-12-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48486
27.

論文

論文
早川, 和一 ; 唐, 寧 ; 鳥羽, 陽 ; 亀田, 貴之 ; Hayakawa, Kazuichi ; Ning, Tang ; Toriba, Akira ; Kameda, Takayuki
出版情報: ぶんせき.  402  pp.278-284,  2008-06-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48485
概要: 東アジア地域では,急速な産業発展に伴って,環境問題も深刻化している。本稿では,筆者(早川)が拠点リーダーを務め平成14~18 年度にわたって実施した文部科学省21世紀COE プログラム「環日本海域の環境計測と長期・短期変動予測」の研究成果を 含め,東アジアの有害大気汚染物質としてクローズアップされている多環芳香族炭化水素とニトロ多環芳香族炭化水素に焦点を合わせて,分析化学研究の現状を紹介し,今後の課題について展望する。 続きを見る
28.

論文

論文
小玉, 修嗣 ; 早川, 和一 ; Kodama, Shuji ; Hayakawa, Kazuichi
出版情報: ぶんせき.  303  pp.167-168,  2000-03-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48484
29.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ぶんせき.  268  pp.323-327,  1997-04-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48483
30.

論文

論文
早川, 和一 ; 山本 , 敦 ; 宮崎, 元一 ; Hayakawa, Kazuichi ; Yamamoto, Atsushi ; Miyazaki, Motoichi
出版情報: ぶんせき.  197  pp.358-363,  1991-05-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48481
31.

論文

論文
早川, 和一 ; 宮崎, 元一 ; Hayakawa, Kazuichi ; Miyazaki, Motoichi
出版情報: ぶんせき.  193  pp.47-53,  1991-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48480
32.

論文

論文
Higashi, Tomomi ; Ohkura, Noriyuki ; Fujimura, Masaki ; Nakai, Satoshi ; Honda, Yasushi ; Saijoh, Kiyofumi ; Hayakawa, Kazuichi ; Kobayashi, Fumihisa ; Michigami, Yoshimasa ; Olando, Anyenda Enoch ; Hitomi, Yoshiaki ; Nakamura, Hiroyuki ; 東, 朋美 ; 大倉, 徳幸 ; 藤村, 政樹 ; 西條, 淸史 ; 早川, 和一 ; 小林, 史彦 ; 道上, 義正 ; 人見, 嘉哲 ; 中村, 裕之
出版情報: Atmospheric Environment.  97  pp.544-551,  2014-11-01.  Elsevier Ltd
URL: http://hdl.handle.net/2297/00049597
概要: 金沢大学医薬保健研究域医学系<br />Asian dust, known as kosa in Japanese, is a major public health concern. In this panel study, we eva luated the effects of exposure to kosa on daily cough occurrence. The study subjects were 86 patients being treated for asthma, cough variant asthma, or atopic cough in Kanazawa University Hospital from January 2011 to June 2011. Daily mean concentrations of kosa and spherical particles were obtained from light detection and ranging (LIDAR) measurements, and were categorized from Grade 1 (0 μg/m3) to 5 (over 100 μg/m3). The association between kosa and cough was analyzed by logistic regression with a generalized estimating equation. Kosa effects on cough were seen for all Grades with potential time lag effect. Particularly at Lag 0 (the day of exposure), a dose-response relationship was observed: the odds ratios for Grades 2, 3, 4, and 5 above the referent (Grade 1) were 1.111 (95% confidence interval (CI): 0.995-1.239), 1.171 (95% CI: 1.006-1.363), 1.357 (95% CI: 1.029-1.788), and 1.414 (95% CI: 0.983-2.036), respectively. Among the patients without asthma, the association was higher: the odds ratios for Grades 2, 3, 4 and 5 were 1.223 (95% CI: 0.999-1.497), 1.309 (95% CI: 0.987-1.737), 1.738 (95% CI: 1.029-2.935) and 2.403 (95% CI: 1.158-4.985), respectively. These associations remained after adjusting for the concentration of spherical particles or particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5). Our findings demonstrate that kosa is an environmental factor which induces cough in a dose-response relationship. © 2014 Elsevier B.V.<br />Embargo Period 12 months 続きを見る
33.

その他

その他
金沢大学フロンティアサイエンス機構 ; 早川, 和一 ; 太田, 富久 ; 池本, 良子 ; Hayakawa, Kazuichi ; Ohta, Tomihisa ; Ikemoto, Ryoko
出版情報: FSO Newsletter = Frontier Science Organization Newsletter.  8  pp.11-11,  2011-11-01.  金沢大学フロンティアサイエンス機構 = Frontier Science Organization Kanazawa University
URL: http://hdl.handle.net/2297/30125
34.

論文

論文
戸次, 加奈江 ; 滝上, 英孝 ; 鈴木, 剛 ; 唐, 寧 ; 鳥羽, 陽 ; 亀田, 貴之 ; 早川, 和一
出版情報: 環境化学 = journal of environmental chemistry.  21  pp.27-33,  2011-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39396
概要: Polycyclic aromatic hydrocarbons (PAHs) and dioxins have several toxic properties, including mutagenicity, carcinogenici ty and reproductive toxicity. PAHs mainly originate from the burning of petroleum and coal, while dioxins originate mainly from waste incineration and agrochemicals. Both PAHs and dioxins have aryl hydrocarbon receptor (AhR) binding activity which is related to toxicity of PAHs and dioxins. In this study, we evaluated AhR binding activity of airborne particles collected in Beijing, China and Kanazawa, Japan by DR-CALUX and the contribution of PAHs and dioxins to this activity. AhR binding activity of airborne particles in Beijing (1,200 ng • m-3) was four hundred times higher than in Kanazawa (2.7 ng • m-3). The composition of PAHs didn′t show large difference in Beijing and Kanazawa. The contribution of the PAHs to CALUX-TEQ was higher than dioxins and especially high in Kanazawa (10.4 %). These results suggest that PAHs show large contribution to the toxicity of airborne particles, and other kinds of PAH and PAH related compounds will also contribute to that toxicity. The difference of concentration and composition of these compounds result in the different level of toxicity of airborne particles in each city. 続きを見る
35.

論文

論文
早川, 和一 ; 木津, 良一 ; 安藤, 京子 ; 村橋, 毅 ; 東, 成見 ; 山本, 茂樹 ; 長谷川, 幸司 ; 中浜, 慶子 ; 山下, 克美 ; 松本, 健 ; 後藤, 純雄
出版情報: 環境化学 = journal of environmental chemistry.  7  pp.545-552,  1997-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39393
概要: 「ナホトカ号」から抜き取った重油, 環境試料 (大気, 漂着重油, 海水) 中の芳香族成分をGC/MS, 蛍光検出HPLCで定着した。重油からはベンゼン, トルエン, エチルベンゼン, キシレン, ナフタレン, アセナフテン, フルオレン, アントラセン, フルオランテン, ピレン, ベンツ [a] アントラセン, クリセン, ベンゾ [b] フルオランテン, ベンゾ [k] フルオランテン, ベンゾ [a] ピレン, ジベンツ [a, h] アントラセン, ベンゾ [ghi] ペリレンが検出された。 大気中ベンゼン, トルエン, キシレン, ナフタレン濃度は有毒なレベルより遥かに低かった。しかし, モデル実験から重油流出直後はベンゼン, トルエン, キシレン, ナフタレン濃度は高いことが推定された。漂着重油中のナフタレン濃度は低下傾向が認められたが, ピレン, ベンゾ [a] ピレン濃度はほとんど同じであった。ナフタレンの減少は揮散のためと考えられた。また, 海岸砂中の多環芳香族炭化水素類の組成は漂着重油中のそれと類似していた。ベンゾ [a] ピレンの海水中濃度は低下傾向を示した。 重油の変異原性, DNA損傷についても調べた。重油はSalmonella typhimurium TA98及びTA100株に対し間接変異原性を示した。また, 重油で処理するとヒトFL細胞中でp53遺伝子を活性化させることから, DNA損傷を引き起こすことが明らかとなった。 Aromatic hydrocarbons in the oil spilled from“the Nakhodka”and in the environmental samples including air, reached oil and sea water were determined by gas chromatography/mass spectrometric detection and high-performance liquid chromatography/fluorescence detection. Aromatic hydrocarbons determined in the oil were as follows: benzene, toluene, ethylbenzene, xylenes, naphthalene, acenaphthene, fluorene, anthracene, fluoranthene, pyrene, benz [a] anthracene, chrysene, benzo [b] fluoranthene, benzo- [k] fluoranthene, benzo [a] pyrene, dibenz [a, h] anthracene and benzo [ghi] perylene. Concentrations of benzene, toluene, xylenes and naphthalene in the air collected at contaminated seashores were much lower than their toxic levels. However, a model experiment suggested that their concentrations in the air might be higher just after the oil spill. Although the naphthalene concentration in the reached oil samples tended to decrease with time, pyrene and benzo [a] pyrene concentrations were relatively constant. The decrease in naphthalene concentration in the reached oil samples was considered to be due to vaporization. Benzo [a] pyrene concentrations in sea water tended to decrease with time. The mutagenicity and DNA damage of the oil were assayed. The oil showed indirectacting mutagenicity in the Salmonella typhimurium TA98 and TA100 strains in the presence of S9 mix. Production of p53 protein was enhanced in human FL cells after the treatment with the oil, indicating that the oil caused DNA damage. 続きを見る
36.

論文

論文
早川, 和一 ; 今泉, 範子
出版情報: 水質汚濁研究 = Japan journal of water pollution research.  11  pp.79-82,  1988-01-01.  水環境学会 = Japan Society on Water Environment
URL: http://hdl.handle.net/2297/39387
37.

論文

論文
岸田, 真男 ; 今村, 清 ; 亀田, 貴之 ; 早川, 和一 ; 坂東, 博
出版情報: 環境化学 = journal of environmental chemistry.  20  pp.173-181,  2010-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39404
概要: A determination method of atmospheric oxygenated polycyclic aromatic hydrocarbons (Oxy-PAHs) in particulate matter and t he gaseous phase using gas chromatograph (GC)-mass spectrometer (MS) was studied in the present study. First, we obtained fundamental data of GC-MS analyses (mass spectra and calibration curves) of twelve Oxy-PAHs as follows: acenaphthenequinone (AceQ), 1,4-naphtoquinone (1,4-NQ), 9-fluorenone (9-F-one), 1,4-phenanthrenequinone (1,4-PQ), 1,4-, 9,10-anthaquinone (1,4-, 9,10-AQ), 1-hydroxyanthrquinone (1-OHAQ), 1,2-benzanthraquinone (1,2-BAQ), benz[c]phenanthrene[1,4]quinine (BcP-1,4Q), 3,4-dihydrobenzo[a]anthracene-1(2H)-one (BaA-one), 1,4-chrysenequinone (1,4-CQ) and 9,10-dihydrobenzo[a]pyrene-7(8H)-one (BaP-one). Subsequently, to evaluate collection efficiency of Oxy-PAHs, air was passed through a quartz-fiber filter (QFF) spiked with authentic Oxy-PAHs and then through cleaned polyurethane form (PUF) plugs using a mini-pump or a low-volume air sampler for 24 h in the dark at a constant room temperature (20 or 35 °C). Oxy-PAHs retained on the QFF and those trapped within PUF plugs were simultaneously Soxhlet extracted, purified with silica by gel column chromatography and determined using GC-MS. The calibration curves for the determination of the twelve Oxy-PAHs were proportional in the concentration range between 0.02 and 1.0 μg/mL with r2 values of 0.960-0.999. Among the twelve Oxy-PAH compounds examined, recoveries of six compounds (1,4-NQ, 9-F-one, 9,10-AQ, 1,2-BAQ, BaA-one and BaP-one) during sampling, Soxhlet-extraction and clean-up procedures sufficiently yielded 79-127% at a room temperature of 20 °C and 57-127% at 35 °C . The method detection limits (MDLs) of the six compounds ranged between 0.61-1.07 ng/m3. The proposed method was applied to the determination of the six Oxy-PAH compounds in the atmosphere. Air sample was collected at an urban location of Osaka, Japan for 12-13 February 2007. 1,4-NQ, 9-F-one and 9-F-one were detected in the sample at concentration level of approximately 0.7-3 ng/m3. 続きを見る
38.

論文

論文
戸次, 加奈江 ; 唐, 寧 ; 鳥羽, 陽 ; 早川, 和一
出版情報: 産業医科大学雑誌.  30  pp.39-45,  2008-03-01.  産業医科大学学会
URL: http://hdl.handle.net/2297/32486
概要: 大気中には様々な有機汚染物質が含まれている.そのうち多環芳香族炭化水素(PAH)およびニトロ多環芳香族炭化水素(NPAH)は,化石燃料などの燃焼に伴って発生し,ヒトの健康に影響をおよぼす物質である.環日本海域の4ヶ国,中国,ロシア,韓国,日 本は,主要エネルギーの種類や生活様式,産業構造や事業所の設備などが異なり,その結果大気汚染のレベルと中身も大きく異なると推定される.そこで,本報では中国と日本の製鉄業を中心とする都市である鉄嶺と北九州を選び大気粉塵を捕集後PAH,NPAH,変異原性,活性酸素種(ROS)生成能を測定し化学物質と毒性の点から比較評価を行った.PAH,NPAH濃度は中国で高濃度を示し,冬高夏低の傾向が見られた.また変異原性は冬に高いが,ROS生成能は夏に高くなる傾向が見られ,変異原性とROS生成能には異なる原因物質が関与すると考えられた.PAH,NPAHとは異なる化合物の寄与も大きいことが考えられた. Airborne participate matters contain many kinds of organic pollutants. Among them, polycyclic aromatic hydrocarbons (PAH), nitropolycyclic aromatic hydrocarbons (NPAH) and quinoid PAHs were reported to have several human health effects. We collected airborne particulates in Kitakyushu, Japan and Tieling, China in summer and winter, and analyzed the PAH and NPAH to evaluate the direct- and indirect-acting mutagenicities and generating activities of reactive oxygen species (ROS). The concentrations of PAHs and NPAHs in Tieling were much higher than in Kitakyushu, with seasonal variations. The mutagenicity level was higher in winter while the ROS generation activity was higher in summer. These results suggest that concentrations of PAH and NPAH didn' t correlate with mutagenicity and ROS generation activity. More studies are needed on the environmental behaviors of compounds other than PAHs and NPAHs, such as quinoid PAHs, and their biological activities. 続きを見る
39.

論文

論文
唐, 寧 ; 伊崎, 陽彦 ; 徳田, 貴裕 ; 季, 若男 ; 董, 麗君 ; 呉, 慶 ; 周, 志俊 ; 黄, 蓉 ; 林, 振宇 ; 亀田, 貴之 ; 鳥羽, 陽 ; 島, 正之 ; 早川, 和一
出版情報: 分析化学 = BUNSEKI KAGAKU.  62  pp.267-273,  2013-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/36937
概要: Urban air contains various kinds of organic pollutants. Among them, several polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are carcinogenic and/or endocrine disrupting. PAHs and NPAHs in the atmosphere mainly originate from imperfect combustion of organic matter, such as petroleum and coal. In this study, total suspended particles (TSP) were collected in three different particulate size fractions by using Andersen low-volume air samplers in Shenyang, Shanghai and Fuzhou, China, in the winter and summer seasons in 2010. Nine PAHs and twelve NPAHs in the extracts from the TSP were analyzed by HPLC with fluorescence detection and chemiluminescence detection, respectively. The mean concentrations of the sums of the nine PAHs and twelve NPAHs were highest in Shenyang and lowest in Fuzhou. In each city, more than 80% of the total PAHs and total NPAHs were found in the fine particulate fraction (<2.1 μm). All PAHs and NPAHs were clearly higher in the winter than in the summer. Furthermore, the ratio of the molar concentrations of 1-nitropyrene to pyrene ([1-NP]/[Pyr]), which is a suitable indicator to estimate the contribution of diesel-engine vehicles and coal combustion to urban TSP, were smaller in Shenyang in the winter. However, in Shanghai, Fuzhou and Shenyang (summer), the [1-NP]/[Pyr] ratios were close to those of particulates released from diesel-engine automobiles. Our study showed that the major contributors of atmospheric PAHs and NPAHs were diesel-engine vehicles both in the winter and the summer in Shanghai and Fuzhou, and in the summer in Shenyang. However, in the winter in Shenyang, atmospheric PAHs and NPAHs seemed to be affected by the mixture of coal combustion systems, such as coal heating and diesel-engine vehicles. 2010年の冬季及び夏季に中国の東部に位置する瀋陽,上海及び福州で総浮遊粒子状物質をアンダーセン式ローボリウムエアサンプラーを用いて粒径別(<2.1 μm,2.1~7 μm,>7 μm)に捕集した.強い発がん性または内分泌かく乱性を有する9種の多環芳香族炭化水素(PAH)と12種のニトロ多環芳香族炭化水素(NPAH)をそれぞれ高速液体クロマトグラフ(HPLC)蛍光検出法,HPLC化学発光検出法で分析した.その結果,3都市の大気中PAH,NPAH濃度はいずれも冬高夏低の季節変動を呈し,また季節によらず瀋陽で最も高く,福州で最も低いことが分かった.また3都市の大気中PAH,NPAHの80% 以上は呼吸器への沈着率の高い微小粒子画分(<2.1 μm)に存在した.さらに,大気中PAH,NPAHの主要発生源の識別マーカーであるピレンに対する1-ニトロピレン濃度比を3都市で比較した結果,上海,福州及び夏季の瀋陽の大気中PAH,NPAHの主要発生源がディーゼル車であり,冬季の瀋陽はディーゼル車と石炭暖房施設の両方であることが明らかになった. 続きを見る
40.

論文

論文
唐, 寧 ; 伊崎, 陽彦 ; 徳田, 貴裕 ; 季, 若男 ; 董, 麗君 ; 呉, 慶 ; 周, 志俊 ; 黄, 蓉 ; 林, 振宇 ; 亀田, 貴之 ; 鳥羽, 陽 ; 島, 正之 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  62  pp.267-273,  2013-01-01.  日本分析化学会
URL: http://hdl.handle.net/2297/43418
概要: Urban air contains various kinds of organic pollutants. Among them, several polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are carcinogenic and/or endocrine disrupting. PAHs and NPAHs in the atmosphere mainly originate from imperfect combustion of organic matter, such as petroleum and coal. In this study, total suspended particles (TSP) were collected in three different particulate size fractions by using Andersen low-volume air samplers in Shenyang, Shanghai and Fuzhou, China, in the winter and summer seasons in 2010. Nine PAHs and twelve NPAHs in the extracts from the TSP were analyzed by HPLC with fluorescence detection and chemiluminescence detection, respectively. The mean concentrations of the sums of the nine PAHs and twelve NPAHs were highest in Shenyang and lowest in Fuzhou. In each city, more than 80% of the total PAHs and total NPAHs were found in the fine particulate fraction (<2.1 μm). All PAHs and NPAHs were clearly higher in the winter than in the summer. Furthermore, the ratio of the molar concentrations of 1-nitropyrene to pyrene ([1-NP]/[Pyr]), which is a suitable indicator to estimate the contribution of diesel-engine vehicles and coal combustion to urban TSP, were smaller in Shenyang in the winter. However, in Shanghai, Fuzhou and Shenyang (summer), the [1-NP]/[Pyr] ratios were close to those of particulates released from diesel-engine automobiles. Our study showed that the major contributors of atmospheric PAHs and NPAHs were diesel-engine vehicles both in the winter and the summer in Shanghai and Fuzhou, and in the summer in Shenyang. However, in the winter in Shenyang, atmospheric PAHs and NPAHs seemed to be affected by the mixture of coal combustion systems, such as coal heating and diesel-engine vehicles. 2010年の冬季及び夏季に中国の東部に位置する瀋陽,上海及び福州で総浮遊粒子状物質をアンダーセン式ローボリウムエアサンプラーを用いて粒径別(<2.1 μm,2.1~7 μm,>7 μm)に捕集した.強い発がん性または内分泌かく乱性を有する9種の多環芳香族炭化水素(PAH)と12種のニトロ多環芳香族炭化水素(NPAH)をそれぞれ高速液体クロマトグラフ(HPLC)蛍光検出法,HPLC化学発光検出法で分析した.その結果,3都市の大気中PAH,NPAH濃度はいずれも冬高夏低の季節変動を呈し,また季節によらず瀋陽で最も高く,福州で最も低いことが分かった.また3都市の大気中PAH,NPAHの80% 以上は呼吸器への沈着率の高い微小粒子画分(<2.1 μm)に存在した.さらに,大気中PAH,NPAHの主要発生源の識別マーカーであるピレンに対する1-ニトロピレン濃度比を3都市で比較した結果,上海,福州及び夏季の瀋陽の大気中PAH,NPAHの主要発生源がディーゼル車であり,冬季の瀋陽はディーゼル車と石炭暖房施設の両方であることが明らかになった. 続きを見る
41.

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亀田, 貴之 ; 片山, 裕規 ; 後藤, 知子 ; 鳥羽, 陽 ; 唐, 寧 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  62  pp.979-984,  2013-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44505
概要: A simple and sensitive method for measuring quinoid polycyclic aromatic hydrocarbons (PAHQs) in soluble organic fraction (SOF) of airborne particles based on two-dimensional high-performance liquid chromatography (HPLC) with fluorescence detection was established. The system involves a reversed phase column with naphtylethyl groups bonded silica packing material for sample clean-up, a 6-port switching valve, an ODS column for trapping the fraction containing PAHQs, a reversed phase column with cholesteryl groups bonded silica packing material for sample separation, and a Pt-Rh catalytic column for the reduction of PAHQs to a corresponding fluorescent compound. The accuracy of the assay, as applied to airborne particulate sample extracts spiked with known amounts of PAHQs were 91 – 107%. The detection limits were 19 to 2000 fmol per injection (signal-to-noise ratio = 3), and the calibration range was from 1 to 100 pmol with excellent proportionality (R2≥0.9992) for four kinds of PAHQs: benz[a]anthracene-7,12-dione, fluoranthene-2,3-dione, pyrene-1,6-dione, and pyrene-1,8-dione. PAHQs in SOF of airborne particles collected in Kyoto, Japan were successfully measured using the established analytical method with simple sample-preparation steps: ultrasonic extraction in organic solvent and concentration under reduced pressure and/or a nitrogen stream. 続きを見る
42.

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鳥羽, 陽 ; 本間, 千春 ; 宇於崎, 和香 ; Chuesaard, Thanyarat ; 唐, 寧 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  63  pp.23-29,  2014-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44506
概要: A high-performance liquid chromatographic (HPLC) method with fluorescence detection was developed for the quantification of polycyclic aromatic hydrocarbons (PAHs) in cigarette mainstream and sidestream smoke particulates. Fifteen kinds of PAHs classified as priority pollutants by the US EPA were quantified with six perdeuterated PAHs as internal standards. The smoke filter samples obtained from 3 brands of cigarettes using standardized smoking conditions were extracted with dichloromethane, and then treated with tandem solid phase extraction cartridges (Silica and Neutral Alumina). The limits of detection ranged from 0.24 to 2.2 pg, and were more sensitive than those by GC-MS. The analytes were quantified by using the internal standards, and the developed method achieved sufficient reproducibility and accuracy. The PAH levels in mainstream and sidestream smoke from 3 cigarette brands were in the range of 0.2 – 305 ng cigarette−1 and 26.4 – 6160 ng cigarette−1, respectively. The total PAH content in sidestream smoke was more than 10 times higher compared with that of mainstream smoke. This method should be useful as an optional analytical method to quantify PAHs in cigarette smoke particulates. 続きを見る
43.

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今成, 登志男 ; 大久保, 登 ; 早川, 和一 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  28  pp.285-288,  1979-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44504
概要: 生体試料中の金属を電気透析試料調製器によって陽イオンとして直接抽出する方法(A法)とEDTA-金属錯体として陰イオンとして抽出する方法(B法)について条件の検討を行った. A法の条件は泳動液0.05N酢酸,電流密度15mA/cm2,抽出時間 (20~40)分,B法の条件は泳動液0.05N水酸化アンモニウム-1m M EDTA,電流密度20mA/cm2,抽出時問(20~40)分であった.A法では鉄(III),銅(II)の回収率80%,亜鉛(II)の回収率は90%,一方B法については鉄(III),亜鉛(II)の回収率100%,銅(II)の回収率は95%であった.たん白質として牛血清アルブミン,電解質として塩化ナトリウムの共存の影響を調べた後,B法を血しょう中のアルブミン結合亜鉛の分析に応用した. The extraction of metals from biological materials by an electrodialytic sample preparator was studied. Two procedures are proposed in this method : one depends on the extraction of metals as cationic ions (Mode A) and the other depends on the extraction of metal-EDTA complexes as anionic ions (Mode B). The basic conditions for Mode A are : carrier solution; 0.05 N CH3COOH, current density; 15 mA/cm2, extraction time; (2040) min. The conditions for Mode B are : carrier solution; 0.05 N NH4OH-1 mM EDTA, current density; 20 mA/cm2 and extraction time; (2040)min. The recoveries of Fe(III), Cu(II) and Zn(II) in Mode A were 90, 80 and 90%, and in Mode B the recoveries were 100, 95 and 100% respectively. The effects of electrolytes and proteins on the extraction of metals were examined, and the application of Mode B for the determination of albumin bound zinc in human plasma was carried out as follows : the supernatant containing albumin bound zinc was obtained by polyethylene glycol treatment and subjected to electrodialysis for 40 min according to the conditions described in Mode B. Albumin bound zinc in the extract was determined by atomic absorption spectrometry (AAS). Total plasma zinc was measured according to direct dilution method by AAS and α2-macroglobulin bound zinc was obtained by the difference. 続きを見る
44.

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木津, 良一 ; 安藤, 京子 ; 早川, 和一
出版情報: 衛生化学 = Eisei kagaku.  44  pp.321-333,  1998-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44931
概要: The Russian tanker Nakhodka met a hull-broken accident in sailing in the Sea of Japan on January 2, 1997, releasing approximately 6200 kl of heavy oil into the Sea of Japan. The spilled oil was driven by the prevailing winds and water currents and polluted the coastline from the Shimane Prefecture through the Yamagata Prefecture. While much effort was made to remove the reached oil, many workers engaged in oil-removing complained of an eyeache, giddiness, a headache, etc. These symptoms were considered to be caused by volatile chemicals in the oil. Although the greater part of the oiled coastline was cleaned shortly after the oil pollution, there is concern that sands, rocks and sea water of the shore were still contaminated with chemicals included in the oil. Furthermore, some part has remained not to be treated. Extensive scientific studies were conducted to 1) evaluate the influence of volatile chemicals in the spilled oil on the health of oil-removing workers, 2) assess the impact of the spill on the ecosystem, 3) where and how long the contamination by the oil or chemicals persists in the environment. This paper reviews the activities and researches made after the Nakhodka oil spill accident. 続きを見る
45.

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山本, 敦 ; 松永, 明信 ; 関口, 久義 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  31  pp.47-50,  1985-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44930
概要: Photometric ion chromatography is a novel method by using the photometer as a detector. A feature of this method is the use of light absorbing ion in the mobil phase, and the appearance of transparent sample ion in the effluent is detected by "trough"in the base line absorbance. We applied this technique by using a conventional HPLC system equipped with a commercially available ion exchange separation column to the determination of bromate in such foodstuffs as bread and kamaboko. Sample solution was prepared by aqueous extraction and mixed with acetone for removal of proteins. After evaporation of the organic solvent, the aqueous solution was dechlorinated by a DOWEX column (Ag-form), and then was subjected to chromatography. Samples of bread and kamaboko were spiked with 5.4 ppm and 8.4 ppm of bromate, respectively, and examined by the above method. The average recoveries were 88.3% in bread and 82.9% in kamaboko, and the coefficients of variation were 7.7% and 7.9%, respectively. The detection limit was 1 ppm. The above findings indicate that bromate can be detected by HPLC using conventional instrumentation, and the sensitivity of this system is comparable to conductimetric detection. 続きを見る
46.

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早川, 和一 ; 山本, 敦 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  40  pp.1-12,  1994-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44934
概要: Ion chromatography (IC), which was introduced in 1975, has become widely used for the sensitive and simultaneous determination of ions. In the early stage, the IC system consisted of two ion-exchange columns (separator and suppressor, respectively) and a conductivity detector. Although this combination is still the most popular, new forms of separation and suppression have been developed. On the other hand, an indirect photometric detection using a UV detector has become popular in IC and other detectors commonly used in HPLC also have been used. Each of them has specific advantages for different types of analyses. Thus, IC is now defined as a form of liquid chromatography of ions. This article reviews new developments of the different forms of IC and their applications, especially to environmental samples, foods, biological materials and drugs, from reports published since 1990. 続きを見る
47.

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吉田, 育世 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  31  pp.317-323,  1985-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44928
概要: Simultaneous determination of carboxylic acids and inorganic anions was investigated by photometric ion chromatography w ith phthalate solution as an eluent. The retention time and the peak area of carboxylic acids changed remarkably with eluent pH. The optimum conditions at present were as follows : analytical column, OYOBUNKO ASA-4000 (4.6 mm i.d.×25 cm) ; eluent, 5×10-4 M disodium phthalate ; flow rate, 2 ml/min ; column temperature, 40°C ; detection wavelength, 240 nm ; injection volume, 100 μl. The detection limits for several carboxylic acids as 3 times noise were 0.05-0.07 mg/l in sample solution. Their calibration curves showed straight lines by the peak area method. The present method has an advantage to determine simultaneously not only carboxylic acids but also inorganic anions. Under the condition described above, both carboxylic acids and inorganic anions in several liquid foods were easily determined by direct injection of the sample prepared with only dilution. 続きを見る
48.

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松永, 明信 ; 山本, 敦 ; 水上, 英一 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  34  pp.70-74,  1988-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44933
概要: A high-performance liquid chromatographic method using post column reaction system was established for the determination of polyphosphates (PP). Linear polyphosphates with the range of polymerization from 2 to 9 (P2-P9) could be separated on an anion exchange column, TSK GEL DEAE-5PW (Toyo Soda), with 0.01 M HNO3 containing NaNO3 as a mobile phase at flow rate of 1.0 ml/min, with a linear gradient in NaNO3 concentration at one hour intervals. PP were detected as the decrease of absorbance at 500 nm of ferric-sulfosalicylate complex by means of an on-line post column reaction at room temperature, with 0.5 mM FeCl3 containing 2.5 mM sulfosalicylic acid as reaction reagent at flow rate of 0.5 ml/min. The proposed method was applied to the analysis of 30 different commercial products of soft drinks. The pretreatment only necessary after mixing the sample with an equal volume of 0.01 M HNO3 was filtration through 0.45 μm pore size filter. P2-P6 (total 0.231 g/kg) and P2-P4 (0.070 g/kg) were found from 2 kinds of the samples, respectively. The determination limit was 0.02 m mol/kg for all of the PP. 続きを見る
49.

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宮崎, 元一 ; 早川, 和一 ; 飯田, 寿恵 ; 藤井, ちず子
出版情報: 衛生化学 = Eisei kagaku.  28  pp.282-285,  1982-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44932
概要: A simple method by using a column packed with Amberlyst-15 resin was established to remove metal ions which affect on PO V and TBA tests for lipid peroxidation. A methanol solution (2 ml) of lipid containing metal ions was applied to the column (0.5 cm×5 cm), and eluted with methanol (6 ml). Metal ions such as Cu2+, Fe3+ and Mn2+ were retained on the column, whereas linoleic acid, linolenic acid and methyl linolenate were completely recovered in the eluate (8 ml). By testing the peroxidized lipid with POV and TBA methods, the recoveries of the lipid mixture after the procedure were more than 85% (POV) and more than 99% (TBA). This pretreatment by using Amberlyst-15 column is available for the peroxidation tests of lipid. 続きを見る
50.

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論文
山本, 敦 ; 松永, 明信 ; 牧野, 正雄 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  33  pp.174-178,  1987-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44937
概要: A method for the simultaneous determination of organic acids was investigated by photometric ion chromatography by using two different eluents. A 4.6 mm i.d.×25 cm stainless column packed with MCI GEL SCA 01 (Mitsubishi Chemical Ind., Ltd.) was used as a separator column. Sample was injected into this column previously equilibrated with 1 mM citraconic acid at pH 6.8. After elution of monobasic organic acids, the eluent was exchanged to a stronger one, 1 mM m-sulfobenzoic acid at pH 6.8. Dibasic organic acids were eluted before the column reequilibration with the secondary eluent. On the other hand, tribasic organic acids such as citric acid were eluted with the secondary eluent. To prevent the base line disorder due to the eluent exchange, the determination at 254 nm was performed. Because this wave length is an isosbestic point of the two eluents. Sour-taste agents in soft drinks could be analysed directly after dilution of samples. 続きを見る
51.

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早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  34  pp.210-224,  1988-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44916
概要: Ion chromatography (IC) with conductivity detection, which was introduced in 1975, has become widely used for the simultaneous determination of inorganic and organic ions. On the other hand, photometric ion chromatography (PIC) based on the difference of absorbances of sample and eluent (mobile phase) species has attracted much attention in the recent field of IC, since this technique has potential advantages over IC methods with conductivity detection. This technique which allows IC on a conventional single column HPLC system with an absorbance detector gives compatible sensitivity to conductivity detection. This paper deals mainly with indirect PIC methods performed by both ion exchange and reversedphase modes, where non-UV-absorbing ions are detected as positive and negative peaks by using UV-absorbing ions in the eluent (mobile phase). The features of PIC have been reasonably well known, but it is necessary to understand principles and conditions of PIC for the effective use of this technique. This paper reviews a number of significant reports which deal with the optimisations of separating column, eluent (mobile phase), detection wavelength, sensitivity and restrictions of PIC with its applications. It is also the purpose of this paper to discuss alternative methods and innovations of PIC. 続きを見る
52.

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論文
早川, 和一
出版情報: 藥學雜誌 = Journal of the Pharmaceutical Society of Japan.  114  pp.669-680,  1994-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44501
概要: Recent studies on the three new photometric detection in the liquid chromatographic methods have been reviewed. The detector and systems based on these detection theories and their applications to several fields have been also described. Differential photometric detection using UV-visible absorbing eluents enabled us to examine the retention and detection mechanism of sample and eluent ions in ion exchange chromatography. Photometric detection in ion chromatography determined transparent ionic compounds using indirect photometric detection mode of this theory. This method was useful for many samples such as environmental water and foods. Polarized photometric detection method has been developed by introducing two polarizers on either side of the UV-visible absorbance detector flow cell. The monitor determined optically active compounds as the change in absorbance. This method was applied for determining food additives such as sugars and organic compounds. A HPLC system with a chemiluminescence detector has been developed for the determination of trace levels of mutagenic nitroarenes such as 1, 3-, 1, 6-, 1, 8-dinitropyrenes and 1-nitropyrene. Utilizing this system, their exhaust from vehicles and behavior in air were examined in detail. This system was also used for determining methamphetamines in abuser urine and hair. 続きを見る
53.

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戸次, 加奈江 ; 鳥羽, 陽 ; 唐, 寧 ; 亀田, 貴之 ; 滝上, 英孝 ; 鈴木, 剛 ; 早川, 和一
出版情報: 藥學雜誌 = Journal of the Pharmaceutical Society of Japan.  132  pp.325-329,  2012-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44502
概要: Polycyclic aromatic hydrocarbons (PAHs), some of which are carcinogenic/mutagenic, are generated by combustion of fossil fuels and also released through tanker or oilfield accident to cause a large scale environmental pollution. PAHs concentration in China is especially high in East Asia because of many kinds of generation sources such as coal heating systems, vehicles and factories without exhaust gas/particulate treatment systems. So, the atmospheric pollution caused by PAHs in China has been seriously concerned from the view point of health effects. Like yellow sand and sulfur oxide, PAHs exhausted in China are also transported to Japan. Additionally, strongly mutagenic nitrated PAHs (NPAHs), estrogenic/antiestrogenic PAH hydroxides (PAHOHs) and reactive oxygen species-producing PAH quinones (PAHQs) are formed from PAHs by the chemical reaction during the transport. Furthermore these PAHOHs and PAHQs are produced by the metabolism in animal body. In the biological activities caused by the above PAH derivatives, the structure-activity relationship was observed. In this review, our recent results on the generation of PAH derivatives by atmospheric transport and metabolism are reported. Also, the existing condition of PAHs as atmospheric pollutants is considered. 続きを見る
54.

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柿本, 健作 ; 東條, 俊樹 ; 先山, 孝則 ; 永吉, 晴奈 ; 小西, 良昌 ; 梶村, 計志 ; 中野, 武 ; 畑, 光彦 ; 古内, 正美 ; 唐, 寧 ; 早川, 和一 ; 鳥羽, 陽
出版情報: 環境化学 = Journal of environmental chemistry.  26  pp.89-93,  2016-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/48560
概要: The particle size distributions of dechloranes were determined. For collecting PM, an Andersen air sampler equipped with five-stage quartz fiber filters and a PM0.1 air sampler equipped with six-stage Teflon and inertial SUS fiber filters were used. Particulate matter (PM) was collected in April 2014 by Andersen air sampler and October 2014 and January 2015 by PM0.1 air sampler. The samples were analyzed for Dechlorane Plus (DP), Dechlorane602, Dechlorane603, and Dechlorane604 Component A using gas chromatography high-resolution mass spectrometry. The almost all nanoparticles smaller than 100 nm are reported to reach and deposit in lung periphery, so it is important to reveal the concentration of these dechloranes in nanoparticles. In our study, only DP was detected in PM. DP was detected from all the filter samples. In this study, the particle size distribution of DP was revealed for the first time and the approximately 70 % of DP exist in <2.5 µm fractions and 10 % of DP exist in <0.1 µm fractions of PM samples. 続きを見る
55.

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早川, 和一 ; 西尾, 和佳子 ; 宮崎, 元一
出版情報: 臨床化学 = Japanese Journal of Clinical Chemistry.  11  pp.44-49,  1982-01-01.  日本臨床化学会 = Japan Society of Clinical Chemistry
URL: http://hdl.handle.net/2297/45682
概要: The lipoperoxidation in plasma was the most accelerated by the addition of 8-hydroxyquinoline (8HQ)-Fe (III) chelate among all 8HQ-metal chelate systems examined. The same tendency was also observed for 5-chloro-7-iodo-8HQ (C)-Fe (III) chelate system. The activity of 8HQ-Fe (III) system in lipoperoxidation was the highest at [8HQ]:[Fe (III)]=1: 1. In quinoline derivatives, the ligands which have 8-hydroxyl group and high solubility in lipid were necessary for lipoperoxidation in plasma by Fe (III) chelate systems. From above facts, both of the denaturation of nervous systems in SMON patients ad ministered with C and the antibiotic effects of 8HQ may be considered as the results of lipoperoxidation by C-Fe (III) chelate and 8HQ-Fe (III) chelate, respectively. 続きを見る
56.

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論文
早川, 和一
出版情報: 藥學雜誌 = Journal of the Pharmaceutical Society of Japan.  129  pp.35-43,  2009-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/28398
概要: The wastes, which have explosiveness, toxicity, infectious, and possibility to cause damage to other people's health and environments, are provided the special management municipal wastes or the special management industry wastes. All the treatment processes from collection to disposal is done under strict management. In this report, we focus on the inorganic and organic experimental waste fluid and the infectious waste among the special management municipal waste or industry waste, because of the similar toxic and chemical characteristics to that of biological and chemical weapons. Understanding how the decomposition and treatment of these wastes are actually done, we clarify the issues of the hazardous waste management and discuss on the possibility to develop the new degradation and treatment method for biological and chemical weapons. 続きを見る
57.

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論文
早川, 和一
出版情報: 藥學雜誌 = Journal of the Pharmaceutical Society of Japan.  127  pp.429-436,  2007-03-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/28397
概要: Many hazardous chemicals are absorbed into human body through respiration and have effects on human health. The 21st Century COE (center of excellence) "Environmental Monitoring and Prediction of Long- and Short-term Dynamics of Pan-Japan Sea Area-Construction of Monitoring Network and Assessment of Human Effects" (Leader : Kazuichi Hayakawa, Graduate School of Natural Science and Technology, Kanazawa University) concentrates on atmospheric pollution caused by human activities occurred in countries, Japan, China, Korea and Russia, surrounding Pan-Japan Sea as one of major projects. My talk focuses on atmospheric pollution caused by polycyclic aromatic hydrocarbon (PAH) and nitropolycyclic aromatic hydrocarbon (NPAH), which clearly exists in this area, and demonstrates the following aspects concerning this issue : 1) The 21st Century "Environmental Monitoring and Prediction of Long- and Short-term Dynamics of Pan-Japan Sea Area-Construction of Monitoring Network and Assessment of Human Effects," 2) Importance of PAH and NPAH as hazardous pollutants emitted from combustion of fossil fuels such as coal and oil, 3) Current status of atmospheric pollution of PAH and NPAH of Pan-Japan Sea Area, focusing on coal combustion systems such as heating in China and diesel-engine automobiles in Japan, and 4) Health effects of PAH and NPAH such as lung cancer and endocrine disruption. 続きを見る
58.

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論文
木津, 良一 ; 東, 信一 ; 早川, 和一 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  35  pp.250-255,  1986-03-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/25011
概要: 金沢大学医薬保健研究域薬学系<br />血しょう及び尿中の制がん性白金錯体オキザラート(トランス-l-1,2-ジアミノシクロヘキサン)プラチニウム(II)(l-OHP)の分析法を研究した.種々検討した結果,分析条件は以下のように定めた.前処 理;Dowex 1-X8,Dowex 50 W-X4及びSep-Pak C_<18>カートリッジを一連のカラムとして構成する.この前処理カラムに血しょう及び尿の1mlと引き続き水を流す.前処理カラム溶出液の最初の6ml部分は捨て,次の10ml部分を分取し,高速液体クロマトグラフィー(HPLC)の試料とした.HPLC条件;カラム:Finepak SIL C_<18>(4.6mm i.d.×25cm),カラム温度:50℃,溶離液:水-メタノール(95:5),流速:1ml/min,検出波長:210nm,試料注入量:100μlピーク高さによる検量線は,原点を通る良い直線性を示した.定量下限は,血しょう及び尿中l-OHP濃度0.5μM,再現性はR.S.D.3%程度であった.血しょう及び尿中のl-OHPを高感度で精度良く定量することができた. A method for determination of (trans-l-1, 2-diaminocyclohexane) oxalatoplatinum (II) (l-OHP), introduced by Kidani et al. as one of the promising antineoplastic platinum complexes, in plasma and urine by high performance liquid chromatography (HPLC) was investigated in order to contribute for metabolic study of l-OHP. The recommended pretreatment procedures and HPLC conditions are as follows. Pretreatment of plasma and urine ; pretreatment column is composed of Dowex 1-X8 (5mm i. d.×6cm), Dowex 50W-X4 (5 mm i. d.×3 cm) and Sep-Pak C_<18> cartridge. Blood samples are centrifuged at 1000 g for 3 min to obtain plasma. One ml of plasma or urine is immediately placed on the pretreatment column and is eluted with water at the flow rate of 1.2 ml/min. The initial 6 ml portion of effluent is discarded and subsequent 10 ml portion is collected. An aliquot (100 μl) of the effluent collected is subjected to HPLC. All of these pretreatment procedures are carried out at 5±2℃. HPLC conditions ; column : Finepak SIL C_<18> (4.6 mm i. d.×25cm), eluent : H_2O-MeOH (95 : 5), column temperature : 40℃, flow rate : 1 ml/min, detection wavelength : 210 nm, injection volume : 100 μl. Under the conditions described above, a linear relationship was obtained between peak height and l-OHP concentration in plasma and urine. Determination limit was 0.5 μM l-OHP in sample solutions. Recovery of l-OHP in pretreatment was 86±3% in plasma and 83±2% in urine. A sensitive and precise determination of l-OHP in plasma and urine will be possible by this method. 続きを見る
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早川, 和一 ; 蛯名, 令子 ; 松本, 美枝子 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  33  pp.390-392,  1984-07-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24891
概要: 金沢大学医薬保健研究域薬学系<br />Determination of inorganic anions and cations in some vegetable juices was examined by ultraviolet p hotometric ion chromatography with a conventional HPLC system equipped with a UV monitor and a separating column packed with popular ion exchangers. Inorganic anions such as Cl^-, NO_3^-, and SO_4^<2-> in sample solution were completely separated on a Zipax SAX packed column (50 cm × 2.1 mm I. D.) with 5 × 10^<-3> M disodium phthalate as an eluent and detected at 240 nm. Inorganic cations such as Na^+, NH_4^+, K^+, Mg^<2+>, and Ca^<3+> in sample solution were completely separated on a Zipax SCX packed column (25 cm × 4.6 mm I. D.) with 2.5 × 10^<-3> M copper sulfate as an eluent and detected at 220 nm. Under the conditions described above, the three anions in juices of Chinese cabbage, tomato, and radish, and the five cations in Sep-pak C_<18> treated juice of Chinese cabbage were determined. 続きを見る
60.

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村田, 勝夫 ; 山下, 伸典 ; 小川, 伸明 ; 早川, 和一 ; 谷口, 博士
出版情報: 分析化学 = Japan analyst.  43  pp.203-207,  1994-03-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24843
概要: 金沢大学医薬保健研究域薬学系<br />銅板の日本海型腐食を調べるため, 秋田県, 石川県, 鳥取県の3県に数ヶ所の観測点を設け, 定期的に試料を回収して, その表面を高感度反射・フーリエ変換赤外分光法を用いて分析した.その結果, 腐食生成 物に関して新な化学種の生成は見られなかったが, 表面の酸化物やスルファト錯体の生成の面で, 冬季に著しい腐食反応の進行が見られた.この点は, 瀬戸内海側や太平洋側での観測結果と非常に異なる特徴を示している.又臨海部の試料に特徴的な赤外スペクトルにおけるベースラインの高波数領域への斜傾化は, エメリーペーパーによる試料表面の研磨による検討から, 表面の物理的荒れ現象であることが判明した. Copper plates were exposed to the ambient atmosphere in locations at different distances from the Sea of Japan coastline in order to investigate matal corrosion characteristic of weathering in winter. The samples from along the Sea of Japan coastline at Akita, Kanazawa, and Tottori districts were compared with those of Naruto district. The samples were analyzed by FT-IR reflection absorption spectroscopy (RAS). The formation of sulfato complexes and hydroxy species as well as oxides of Cu_2O and CuO was observed on the samples in all regions, but the formation rate of their species was different. The formation rate of the species from samples along the Sea of Japan coastline rapidly proceeds while that of the samples in Naruto district proceeds slowly in the winter season. Polishing the surface of the copper plate with emery paper revealed that an oblique baseline observed in the IR-RAS spectrum of the corroded samples is attributable to roughness on the surface of the copper plates which is mainly caused by weathering. 続きを見る
61.

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宮川, みどり ; 坂井, 恒 ; 塩谷, 稔哉 ; 木津, 良一 ; 早川, 和一
出版情報: 水環境学会誌 = Journal of Japan Society on Water Environment.  26  pp.869-874,  2003-12-10.  日本水環境学会 = Japan Society on Water Environment
URL: http://hdl.handle.net/2297/24823
概要: 金沢大学医薬保健研究域薬学系
62.

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綿谷, 敏彦 ; 早川, 和一 ; 能村, 京子 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  43  pp.817-822,  1994-10-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24844
概要: 金沢大学医薬保健研究域薬学系<br />The differential chromatogram method was useful to reduce large changes in background response in si ngle column ion chromatography using stepwise elution. Cations (Na^+, K^+, Mg^<2+> and Ca^<2+>) were separated on cation exchange column by stepwise elution using both 0.01 mM and 3.0 mM copper sulfate eluents and detected at 230 nm by indirect photometry. Anions (lactate, acetate, propionate, formate, citrate, Cl^-, NO_2^-, Br^-, NO_3^-, SO_4^<2->, S_2O_3^<2-> and I^-) were separated on an anion exchange column using both 0.3 mM and 1.5 mM disodium phthalate eluents and detected at 270 nm. This method was also successfully applied to conductometric detection. 続きを見る
63.

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石川, 雅章 ; 山本, 政利 ; 増井, 俊夫 ; 早川, 和一 ; 宮崎, 元一 ; 中澤, 裕之 ; 藤田, 昌彦
出版情報: 分析化学 = Japan analyst.  35  pp.309-311,  1986-03-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24840
概要: 金沢大学医薬保健研究域薬学系<br />Determination of inorganic ions in aqueous infusions was studied by photometric ion chromatography ( PIC) using a conventional HPLC system equipped with a UV monitor. Inorganic cations (Na^+, K^+, Mg^<2+> and Ca^<2+>) could be separated on a strong cation exchange column, Oyobunko ASC-4000 column (4.6 mm i. d.×250 mm), with 1×10^<-4> M CuSO_4 for Na^+, K^+ and 2×10^<-3> M CuSO_4 for Mg^<2+>, Ca^<2+> as eluents, and detected at 220 nm. Inorganic anions (Cl^-, PO_4^<3-> and SO_4^<2->) could be separated on a strong anion exchange column, Oyobunko ASA-4000 column (4.6 mm i. d.×250 mm), with 1×10^<-3> M disodium phthal- ate (pH 10) as an eluent, and detected at 260 nm. A sample solution was simply diluted with distilled water, and could be analyzed by PIC. Relative standard deviations (n=5) for above ions in a commercial infusion were below 2.0%. 続きを見る
64.

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村橋, 毅 ; 早川, 和一 ; 岩本, 侑子 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  43  pp.1017-1020,  1994-11-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24842
概要: 金沢大学医薬保健研究域薬学系<br />A simultaneous determination method for polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs (NPAH s) in airborne particulates was developed. Airborne particulates were extracted with benzene/ethanol, cleaned up by liquid-liquid partition, refluxed in the presence of NaSH and then the resultant solution was injected into an HPLC system. The system was hybridized into two systems with different optimum conditions for PAHs and NPAHs by introducing a switching valve and a mini separation column. Mobile phases were acetonitrile/water (75 : 25) for PAHs, and acetonitrile/imidazole HClO_4 buffer (1 : 1) for NPAHs and the postcolumn reagent solution for NPAHs was an acetonitrile solution containing bis(2,4,6-trichlorophenyl)oxalate and H_2O_2. By this method, four NPAHs (1,3-, 1,6-, 1,8-dinitropyrenes and 1-nitropyrene) and eight PAHs (fluoranthene, pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene and coronene) in sub-milligram quantities of airborne particulates were determined chemilumigenically and fluorogenically, respectively using 2-fluoro-7-nitrofluorene as an internal standard within sixty minutes. 続きを見る
65.

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木津, 良一 ; 加藤, 詳子 ; 薄井, 修 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  48  pp.617-622,  1999-05-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/25012
概要: 金沢大学医薬保健研究域薬学系<br />エストロゲン作用の新しいin vitroアッセイ法として, ヒト乳がん由来MCF-7細胞におけるプロゲステロン受容体(PgR)の発現量を指標とする方法を提案し, 現在最もはん用されてぃるE-Scree nアッセイ法と比較するとともに, C重油のエストロゲン作用を検討した. 試料としては, 重油のエタノール抽出物を用いた. PgRの発現量をウエスタンブロット法で測定したところ, 17β-エストラジオール(E_2)処理によりPgRの発現量が高まり, 更にE_2アンタゴニストであるタモキシフェンの処理を加えるとPgRの発現量は減少した. E-Screenアッセイにおいても, E_2及びタモキシフェン処理に対して類似の応答を示し, PgR発現量がエストロゲン作用の良い指標であることが明らかになった. 次に, 重油抽出物のエストロゲン作用について検討した. E_2非存在下では重油抽出物の処理でわずかながらPgRの発現量が高まったが, E_2存在下ではPgRの発現量は減少した. 以上の結果から, 重油中には弱いエストロゲン作用を示し, E_2アンタゴニストとして作用する化合物が含まれることが明らかとなった. また, 重油抽出物の処理では死細胞数の増加が観察された. 重油や環境試料のように細胞死を引き起こす成分を含む可能性がある試料については, 本研究のPgRの発現量を指標とする方法が適していると考えられた. The authors have proposed a new in vitro assay method for estrogenicity. The cellular progesterone receptor (PgR) level in the human breast cancer cell line MCF-7 was measured because PgR has been known to be upregulated by 17β-estradiol (E_2). The cellular PgR level was measured by a western blotting technique. While an E_2 treatment increased the PgR level, tamoxyfen, a typical E_2 antagonist decreased the PgR level elevated by the E_2 treatment. These results revealed that the cellular PgR level is a good indication to evaluate the estrogenicity. Next, the estrogenic activities of Nakhodka heavy oil and a commercial C-heavy oil were examined. Heavy oil crude extracts prepared with ethanol were subjected to the assay. While the extracts increased the PgR level under the E_2-free condition, the extracts decreased the PgR level elevated by the E_2 treatment. These results indicate that the heavy oil contains compounds which show weak estrogenic activity and act as E_2 antagonists. Dead cells were observed after the oil extract treatment, and their number increased with an increase of oil extract concentration in the cell-culture medium. Environmental samples such as oil-extract, river water, and air particulate extract comprise a wide variety of compounds, and are thought to have a cell-killing effect. A cellular PgR expression method is considered to be more appropriate for assessing the estrogenic activities of environmental samples, compared with the existing assay methods, such as the cell-proliferation method (E-Screen assay) and the reporter-gene methods. 続きを見る
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中村, 誠治 ; 今泉, 範子 ; 早川, 和一 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  38  pp.537-577,  1989-11-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/25035
概要: 金沢大学医薬保健研究域薬学系<br />ノンサプレッサー型イオンクロマトグラフィー(IC)としてはん用される電気伝導度検出ICと間接吸光度検出ICの感度特性を検出原理式に基づき,強酸性物質と弱酸性物質について比較した.両法に用いることができ る溶離液種として安息香酸及びフタル酸を用いると,硝酸イオンなどの強酸性物質の検出では,低pH溶離液の電気伝導度検出のほうが感度が高く,弱酸性物質の検出では,高pH溶離液の間接吸光度検出のほうが高かった.共通溶離液としてはん用される低pHのフタル酸溶離液を用いたときの両者による強酸性物質の分析値の相関は良かった.又,溶離液として,1,5-ナフタレンジスルホン酸やベンゼンジスルホン酸を用いると,間接吸光度検出による感度を向上させることができ,強酸性物質の検出でも低pHフタル酸溶離液を用いたときの感度を上回った. The detection sensitivities of anionic compounds by conductivity detection (CD) and indirect photometric detection (IPD) were compared in non-suppressed ion chromatography. The reciprocal of peak area to noise ratio was used to compare the two detection methods for such common eluents as benzoate and phthalate at pH 4.3 and pH 6.7. The sensitivities of strong acid compounds were highest by CD at pH 4.3, while those of weak acid compounds were highest by IPD at pH 6.7. These results were consistent with theoretical equations for the two detection methods. The sensitivities of strong acid compounds by IPD exceeded those by CD with the phthalate eluent at pH 4.3, using eluent species such as 1, 5-naphthalenedisulfonate. Correlations between the two methods were excellent in the determination of inorganic anions in soluble fractions of monthly collected deposits 続きを見る
67.

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玉村, 修司 ; 佐藤, 努 ; 大田, 由貴恵 ; 唐, 寧 ; 早川, 和一 ; 米田, 哲朗
出版情報: 粘土科学討論会講演要旨集.  50  pp.138-139,  2006-09-07.  日本粘土学会
URL: http://hdl.handle.net/2297/6737
概要: 金沢大学大学院自然科学研究科環境動態<br />金沢大学薬学部
68.

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伊藤, 宏 ; 早川, 和一 ; 山本, 敦 ; 村瀬, 篤 ; 星野, 邦広 ; 久野, 稔 ; 早川, 和美
出版情報: 分析化学 = Japan analyst.  54  pp.221-226,  2005-03-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24841
概要: 金沢大学医薬保健研究域薬学系<br />ガスクロマトグラフ(GC)は, 大気, 室内空気をはじめ環境試料中の悪臭, におい分析など幅広い用途で多用される分析装置である.GC装置は, キャピラリーカラムやマススペクトロメトリー検出器の開発に伴 う分離, 同定能力の向上後は, 成熟した分析装置と見られることが多くなった.しかし, インジェクターのセプタムにシリコンゴムシールが使われている.このため, (1)使用温度に上限がある, (2)セプタムの汚染によるバックグラウンドの上昇や妨害ピークが発生する, (3)加熱脱着, 熱分解分析などに専用の装置を必要とする, などの課題が残されている.これらの課題を解決するため, 従来のキャリヤーガスライン外側にもう一層のガスラインを設け, このガスでキャリヤーガスシールする方法(セプタムフリーインジェクターと呼称する)を検討した.その結果, 複雑なシール機構を必要としたインジェクター部の構造を簡略化でき, 前述の課題を解決できることが分かった. The gas-chromatograph (GC) is a type of analytical equipment that has been most commonly used in environmental studies such as concerning offensive odors and residual pesticides. The GC has been regarded as being a well-developed analytical equipment, since the introduction of a capillary column made high-resolution analysis possible, and hyphenation with a mass-spectrometry detector advanced the identification ability. There are, however, several disadvantages to be improved. For instance, a silicone rubber seal is used in a septum for a sample injector. Therefore, (1) there is an upper limit to the applicable temperature, (2) the background level increases and/or interferences are formed by contamination of the septum, and (3) the GC injector requires an exclusive type of equipment for thermal desorption, pyrolysis analyses and so on. To solve these problems, we introduced another carrier gas line, instead of the septum seal outside of the conventional carrier gas line. When the two gas lines are set at the same pressure, leakage of the carrier gas is likely to be prevented, regardless of the existence of hole for the preparing the syringe needle. We called it a "septum-free injector". In this paper, we demonstrate the analytical features of this novel injector. 続きを見る
69.

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宮川, みどり ; 小寺, 康丈 ; 塩谷, 稔哉 ; 木津, 良一 ; 早川, 和一
出版情報: 水環境学会誌 = Journal of Japan Society on Water Environment.  26  pp.437-442,  2003-07-01.  日本水環境学会 = Japan Society on Water Environment
URL: http://hdl.handle.net/2297/24821
概要: 金沢大学医薬保健研究域薬学系
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早川, 和一 ; 平木, 博美 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  34  pp.71-76,  1985-07-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24890
概要: 金沢大学医薬保健研究域薬学系<br />入手が容易なイオン交換カラムを備えた普及型HPLC装置で可能な,無機陰イオンの微量分析条件を検討した.無機陰イオン(炭酸イオン,塩化物イオン,亜硝酸イオン,リン酸イオン,臭化物イオン,硝酸イオン,硫酸 イオン,ヨウ化物イオン)は,フタル酸二ナトリウム溶液を溶離液として,陰イオン交換カラムで分離溶出された後,ベースラインの谷として紫外検出される.炭酸イオン,塩化物イオン,リン酸イオン,臭化物イオン,硝酸イオン,硫酸イオンの同時分析の最適条件は,カラム:Zipax SAX (2.1 mm i.d.×50cm):溶離液:5×10^<-4> Mフクル酸二ナトリウム;流速:1 ml/min; 温度:室温;検出波長:240 nm;注入量:100μlであった.この条件で,検出下限はppbレベルであり,ピーク高さ法と面積法のいずれでも検量線は直線となった.本法を用いると,環境試料中の主要無機陰イオンが短時間に一斉分析でき,しかも本法の分析値は,他法の結果ともよく一致した. A photometric determination method of microamounts of inorganic anions has been developed by conventional high performance liquid chromatography using a popular ion exchange column. Inorganic anions (HCO_3^-, Cl^-, NO_2^-, H_2PO_4^-, Br^-, NO_3^-, SO_4^<2->, and I^-) were separated on an anoin exchange column by using disodium phthalate solution as an eluent, and detected as troughs in the base line absorbance by a UV monitor. The optimum conditions for the determination of HCO_3^-, C1^-, H_2PO_4^-, Br^-, NO_3^-, and SO_4^<2-> were as follows : column, Zipax SAX (2.1 mm i.d. ×50cm) ; eluent, 5×10^<-4>M disodium phthalate ; flow rate, 1 ml/min ; column temperature, ambient ; detection wavelength, 240 nm. Under the conditions described above, detection limits of these anions were at levels as low as ppb. The calibration curves gave straight lines by either peak height or peak area method. Main inorganic anions contained in environmental samples could be simultaneously determined by the proposed method, and their analytical results were close to those obtained by other methods. 続きを見る
71.

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早川, 和一 ; 内海, 彰子 ; 鹿角, 昌平 ; 鳥羽, 陽 ; 木津, 良一 ; 阪口, 利文 ; 山村, 晃 ; 森田, 資隆 ; 民谷, 栄一
出版情報: 水環境学会誌 = Journal of Japan Society on Water Environment.  23  pp.731-736,  2000-11-10.  日本水環境学会 = Japan Society on Water Environment
URL: http://hdl.handle.net/2297/24822
概要: 金沢大学医薬保健研究域薬学系
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早川, 和一 ; 山本, 敦
出版情報: 分析化学 = Japan analyst.  44  pp.417-436,  1995-06-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24839
概要: 金沢大学医薬保健研究域薬学系<br />これまで, 液体クロマトグラフィーにおける吸光度検出器は専ら光吸収を有する化合物を検出する装置であり, その原理と検出器は既に完成されたものとの印象が強かった.本総説は, 上述の概念を大きく変革しつつ ある吸光度検出法の新展開として, 光吸収のない対象物質を検出できる間接吸光度検出法と, 更にその考え方を光学活性物質の検出に向けた偏光吸光度検出法に焦点を合わせ, 著者らの研究成果も含めて紹介する. New photometric detection methods developed for use in liquid chromatography have been reviewed. Differential photometric detection using UV-visible absorbing modifiers enabled us to examine the retention and detection mechanism of not only analytes but also mobile phases. Indirect photometric detection ion chromatography based on this theory separately and sensitively determines ionic compounds using a conventional high-performance liquid chromatographic system with a UV-visible absorbance detector. This method is useful for many kinds of samples such as environmental water, foods and biological materials. Polarized photometric detection mathods with two polarizers on either side of a UV-visible absorbance detector flow cell have been developed. The monitor determines optically active compounds as the change in absorbance. This method was effectively applied for determining sugars and organic acids 続きを見る
73.

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論文
早川, 和一 ; 鳥羽, 陽 ; 亀田, 貴之 ; 唐, 寧
出版情報: 分析化学 = Japan analyst.  56  pp.905-920,  2007-11-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24835
概要: 金沢大学医薬保健研究域薬学系<br />化石燃料の消費量の増加は,大気中に大量の汚染物質を排出し,深刻な健康影響を招いている。有害大気汚染物質の一つに多環芳香族炭化水素(PAH)とニトロ多環芳香族炭化水素(NPAH)がある.このうち,NPA Hは極めて強い変異原性を有するものがあるにもかかわらず,環境中の濃度はPAHよりはるかに低く,しかもNPAHを追跡できる高感度な分析法もなかったため,PAHに比較するとNPAHの環境動態や健康影響に関する研究は大きく立ち遅れていた.本総説では,1980年代の後半から始まった高感度なNPAH分析法の開発研究を解説し,更にそれを用いて急速に展開しているNPAHの発生と大気内動態の解析,並びにヒト暴露測定について最近の動向までを解説する. With an increase in the consumption of fossil fuels, large amounts of pollutants released into the atmosphere cause serious health problems. Polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are among the atmospheric hazardous pollutants. The mutagenicities of several NPAHs are much stronger than those of PAHs, but the concentrations of NPAHs are much lower than those of PAHs in the environment. However, the progress of studies on the environmental behaviors and health effects of NPAHs has been much slower than that of PAHs, because of the lack of a sensitive analytical method available for trace NPAHs. This review deals with the development of sensitive determination methods for NPAHs starting the in late 1980s and recent studies on the contributors and atmospheric behaviors of NPAHs and human exposure to them. 続きを見る
74.

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早川, 和一 ; 平木, 博美 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  32  pp.504-505,  1983-08-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24889
概要: 金沢大学医薬保健研究域薬学系<br />A novel method for the determination of micro amounts of inorganic ions has been developed. The sepa ration of alkaline metal ions (Li^+, Na^+, and K^+) was accomplished on a Zipax SCX packed column (4.6 mm × 12 cm) with 2.5×10^<-4> M copper sulfate as an eluent, and the separation of halogen ions (F^-, Cl^-, and Br^-) was accomplished on a Zipax SAX packed column (4.6 mm × 15cm) with 1.0 × 10^<-3> M sodium benzoate as an eluent. The eluted ions were detected as troughs in base line absorbance of eluent ion at 220 nm or 240 nm. Under the conditions described above, the six ions were easily separated and determined at the levels as low as ppb by using either a peak height method or a peak area method which gave straight calibration curves. Other inorganic ions can be also determined by changing composition and concentration of the eluent. Moreover, this analytical method is economical and simple, since it can be performed with a conventional HPLC system equipped with a single separation column packed with inexpensive and easily available ion exchanger and a photometric detector. 続きを見る
75.

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早川, 和一 ; 西島, 美知子 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  31  pp.160-161,  1982-03-05.  The Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/24888
概要: 金沢大学医薬保健研究域薬学系<br />A novel method for the separation of halogenated anion complexes of platinum metals by reversed-phas e ion-pair partition chromatography has been developed. The separation of RhBr_5^<2->, PdBr_4^<2->,and PtBr_6^<2-> was accomplished on a Hitachi #3050 packed column (3mm×30cm), where 30 % (v/v) acetonitrile-0.02 M phosphate buffer (pH 7) mixture containing 0.1 M tetrabutylammonium bromide and 0.025 M sodium bromide was used as a mobile phase. These anion complexes can be determined at 310nm, and as low as 5×10^<-11> mol of PtBr_6^<-2> can be determined with the peak height method which gave a straight calibration curve. Detecting wavelengths and retention times of the complexes can be altered if the complexes are formed with other halogen ions. This analytical method for micro amounts of platinum metals can remove the mutual metal interferences. 続きを見る
76.

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その他
Chung, Sang Woon ; Hayakawa, Kazuichi ; 早川, 和一
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.54-54,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35305
概要: [研究概要]
77.

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その他
岡, 秀雄 ; 早川, 和一 ; Oka, Hideo ; Hayakawa, Kazuichi
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.55-55,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35306
概要: [研究概要]
78.

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その他
阿久津, 和彦 ; 早川, 和一 ; Akutsu, Kazuhiko ; Hayakawa, Kazuichi
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.64-64,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35315
概要: [研究概要]
79.

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飯尾, 麗子 ; 早川, 和一 ; Iio, Reiko ; Hayakawa, Kazuichi
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.65-65,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35316
概要: [研究概要]
80.

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伊藤, 宏 ; 早川, 和一 ; Ito, Hiroshi ; Hayakawa, Kazuichi
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.66-66,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35317
概要: [研究概要]
81.

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その他
楊, 小陽 ; 早川, 和一 ; Yang, Xiaoyang ; Hayakawa, Kazuichi
出版情報: 金沢大学大学院自然科学研究科環境科学専攻紀要 = Memoirs of Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University.  1  pp.67-67,  2006-03-01.  金沢大学大学院自然科学研究科環境科学専攻幹事会 / 金沢大学
URL: http://hdl.handle.net/2297/35318
概要: [研究概要]
82.

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朴木, 英治 ; 早川, 和一
出版情報: 大気環境学会年会講演要旨集.  44  pp.506-,  2003-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45061
83.

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論文
鈴木, 元気 ; 森川, 多津子 ; 柏倉, 桐子 ; 唐, 寧 ; 鳥羽, 陽 ; 早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  50  pp.117-122,  2015-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45057
概要: 首都圏3地点(野毛、九段、つくば)において、野毛および九段では2006~2013年まで、つくばでは2010~2013年までの夏と冬の大気粉塵を捕集し、多環芳香族炭化水素 (PAH) 9種類およびニトロ多環芳香族炭化水素 (NPAH) 3種類 をそれぞれHPLC-蛍光検出法、HPLC-化学発光検出法で測定し、その濃度の変遷を明らかにした。PAH濃度は野毛、九段で2006年から2008年の間の冬に低下傾向が認められた。NPAH濃度は、野毛では2006年から2011年の間の夏と冬、九段では2007年から2009年の間の夏および2006年から2011年の間の冬に低下傾向が認められた。つくばでは観測期間が2010年から2013年と短く、PAHとNPAHのいずれについても明確な変動傾向は認められなかった。また野毛および九段で[1-NP]/[Pyr]値の低下が確認され、PAH、NPAH濃度低下の要因の一つとして自動車排ガス規制による粉塵およびNOx排出量の減少が考えられた。 Airborne particulates were collected in Noge and Kudan, Japan, in the summer and winter from 2006 to 2013 and in Tsukuba, Japan, in the summer and winter from 2010 to 2013. The polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) were determined by HPLC with fluorescence and chemiluminescence detections, respectively. The decreasing tendencies of the total concentrations of nine PAHs were observed at Noge and Kudan in the winter from 2006 to 2008. The decreasing tendencies of the total concentrations of three NPAHs were observed in both the summer and winter in Noge from 2006 to 2011. The decreasing tendencies of the NPAH concentrations were also observed in Kudan in the winter from 2006 to 2011 and in the summer from 2007 to 2009. The concentration ratio of 1-nitropyrene to pyrene also decreased in Noge and Kudan. As the main reason for the decrease in the urban atmospheric PAH and NPAH concentrations, the Japanese regulation of exhaust gas/particulates from automobiles was considered. 続きを見る
84.

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論文
早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  47  pp.105-110,  2012-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45058
概要: 化石燃料の燃焼に伴って二酸化炭素の他にも種々の化学物質が発生し、気候変動の要因となるばかりでなくヒトの健康や生態系にも影響を及ぼしている。こうした有害化学物質の一つに多環芳香族炭化水素(PAH)及びニトロ多環芳香族炭化水素(NPAH)がある 。以前からPAH、NPAHに発がん性を有するものが多いことは知られていたが、最近、これらの酸化体である水酸化体やキノン体のなかに、内分泌かく乱作用や活性酸素過剰産生作用を示すものがあることも明らかになり、肺がんだけでなく、喘息などのアレルギー疾患や心疾患などとの関連も疑われるようになった。著者は、20年ほど前にHPLC-化学発光検出法による超高感度なNPAH分析法を開発したことを契機に、我が国のみならず、日本海を挟む中国、韓国、ロシアの研究者と協力して大気PAH/NPAHモニタリングネットワークを組織した。そして、今日まで10年以上にわたって、これらの国々の都市とバックグラウンド地点で大気粉塵を継続捕集し、PAH、NPAHを追跡し、汚染レベルや発生源の変化、大気反応、長距離輸送などを追跡してきた。そこで、本大気環境学会賞総説では、著者の東アジアにおけるPAH、NPAHに関する研究成果を中心に、分析法や毒性にも触れながら紹介する。With the increase of consumption of fossil fuels, large amounts of pollutants released into the atmosphere cause serious health problems. Polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are one of the atmospheric hazardous pollutants. The mutagenicities of several NPAHs are much stronger than those of PAHs, but the concentrations of NPAHs are much lower than those of PAHs in the environment. However, the progress of the study on the environmental behaviors and health effects of NPAHs have been much slower than that of PAHs, because of the lack of sensitive analytical methods for trace NPAHs. I developed a highly sensitive determination method for NPAHs by using HPLC with chemiluminescence detection. We organized an atmospheric PAHs and NPAHs monitoring network which covered East-Asian countries surrounding the Japan Sea (Japan, China, Korea and Russia) to collect air samples and applied the above method for the determination of PAHs and NPAHs. This review deals with analytical methods, behaviors and toxicities of PAHs and NPAHs in East Asia. 続きを見る
85.

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論文
浜, 寛貴 ; 徳田, 貴裕 ; 伊崎, 陽彦 ; 大野, 友子 ; 渡辺, 有梨 ; 神田, 哲雄 ; 唐, 寧 ; 亀田, 貴之 ; 鳥羽, 陽 ; 早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  47  pp.1-8,  2012-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45056
概要: 石川県金沢市藤江の幹線道路脇において12年間(1999~2010年)の夏と冬の大気粉塵を捕集し、多環芳香族炭化水素(PAH)6種類(pyrene、benz[a]anthracene、chrysene、benzo[b]fluoranthene 、benzo[k]fluoranthene、benzo[a]pyrene)およびニトロ多環芳香族炭化水素(NPAH)7種類(1,3-、1,6-、1,8-dinitropyrenes、1-nitropyrene、6-nitrochrysene、7-nitrobenz[a]anthracene、6-nitrobenzo[a]pyrene)をそれぞれHPLC-蛍光検出法、HPLC-化学発光検出法で測定し、その変遷を明らかにした。この間に、PAH濃度は冬63.9%、夏75.6%減少、NPAH濃度は冬88.0%、夏89.2%減少した。また[1-NP]/[Pyr]値は冬と夏ともに著しく減少した。自動車排ガス規制の強化によって排出源としての自動車の寄与率が低下したことが、大気中PAH、NPAH濃度および[1-NP]/[Pyr]値が顕著に減少した主要因と考えられた。 Airborne particulates were collected at a roadside site in Kanazawa, Japan, in the summer and winter, 1999, 2004/2005, 2007/2008 and 2010. The polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) were determined by HPLC with fluorescence and chemiluminescence detections, respectively. The total concentration of six PAHs (pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene and benzo[a]pyrene) decreased by the factor of 63.9% in the winter and 75.6% in the summer from 1999 to 2010. The total concentration of seven NPAHs (1,3-, 1,6-, 1,8-dinitropyrenes, 1-nitropyrene, 6-nitrochrysene, 7-nitrobenz[a]anthracene and 6-nitrobenzo[a]pyrene) significantly decreased by the factor of 88.0% in the winter and 89.2% in the summer during the same period. The concentration ratio of 1-nitropyrene to pyrene also significantly decreased in this period, suggesting a decrease in the emission amount. As the main reason for the significant decrease in the PAHs and NPAHs, the regulation of exhaust gas/particulates from automobiles was considered. 続きを見る
86.

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論文
早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  48  pp.pref03_1-,  2013-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45060
87.

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論文
片山, 裕規 ; 後藤, 知子 ; 亀田, 貴之 ; 唐, 寧 ; 松木, 篤 ; 鳥羽, 陽 ; 早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  46  pp.20-29,  2011-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45055
概要: 本研究では,日本および近年大気汚染の著しい中国における大気中多環芳香族炭化水素(PAH)キノン濃度レベルを把握すること,さらに大気内動態を解明するための基礎的なデータを得ることを目的とし,PAHキノンの一種である1,2-benzanthra quinone(benz[a]anthracene-7,12-dione; BAQ)の実大気中観測,ならびに光やオゾンによるPAHの酸化反応によるBAQの生成を実験的に検討した。北京,大阪,輪島における実大気粒子中BAQ濃度を測定したところ,最も高かった北京・冬の濃度は,輪島・冬の濃度の約200倍高い値を示した。またBAQ/benzo[k]fluoranthene(BkF)濃度比を比較したところ,いずれの地点においても夏季のほうが冬季よりも低いという結果を得た。夏季には強い太陽光強度の影響により,BAQの光分解がBkFの光分解以上に促進され,BAQ/BkF比が小さくなったものと考えられた。北京で大規模な黄砂が観測された時期においては,黄砂のほとんど観測されなかった春季よりもBAQ/BkF比は高い値となった。室内反応実験により,中国砂漠土壌粒子表面に担持させたBaAからのBAQ生成を,光照射およびオゾンとの反応によって調べたところ,参照とするグラファイト粒子,およびテフロン粒子よりも土壌粒子表面において反応が促進される傾向があることがわかった。このことから,黄砂期にBAQ/BkF比が高くなる理由の一つとして,黄砂表面上におけるBAQの二次生成が示唆された。 Selected polycyclic aromatic hydrocarbons (PAH), nitrated PAH, and quinoid PAH (PAH-quinone) in airborne particles were simultaneously determined at Beijing, China, Osaka, Japan, and Wajima, Japan. The concentration of particle-associated 1,2-benzanthraquinone (benz[a]anthracene-7,12-dione; BAQ), a quinoid PAH, at Beijing was higher than that at Osaka and Wajima by factors of 35 and 200, respectively. Strong correlations between the BAQ and 2-nitropyrene concentrations in the summer and between the BAQ and 1-nitropyrene concentrations in the winter imply that atmospheric secondary reactions and primary emissions significantly contribute to the occurrence of atmospheric BAQ in the summer and winter, respectively. The concentration ratios of BAQ to benz[k]fluoranthene (BkF) in the summer were lower than those in the winter due to the instability of BAQ under sunlight. The BAQ/BkF ratio at Beijing in the Asian dust season was significantly higher than that in the regular spring season, suggesting that the secondary formation of BAQ is promoted by catalytic effects on the Asian dust surface. 続きを見る
88.

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論文
早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  45  pp.Pref01_1-,  2010-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45054
89.

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論文
早川, 和一
出版情報: 大気環境学会誌 = Journal of Japan Society for Atmospheric Environment.  44  pp.359-359,  2009-01-01.  大気環境学会 = Japan Society for Atmospheric Environment
URL: http://hdl.handle.net/2297/45059
90.

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論文
早川, 和一 ; 塚脇, 真二
出版情報: 日本海域研究 = Japan sea research.  45  pp.1-2,  2014-03-19.  金沢大学環日本海域環境研究センター = Institute of Nature and Environmental Technology Kanazawa University
URL: http://hdl.handle.net/2297/36990
91.

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論文
早川, 和一
出版情報: 日本海域研究 = Japan sea research.  45  pp.61-62,  2014-03-19.  金沢大学環日本海域環境研究センター = Institute of Nature and Environmental Technology Kanazawa University
URL: http://hdl.handle.net/2297/37021
92.

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論文
北村, 敬一郎 ; 中野, 淳 ; 川部, 季美 ; 早川, 和一 ; 佐藤, 雄亮 ; 根本, 鉄 ; 大嶋, 雄治 ; 島崎, 洋平 ; 遠藤, 雅人 ; 服部, 淳彦 ; 鈴木, 信雄
出版情報: 日本海域研究 = Annals of th e Research Institute of the Japan Sea Region.  42  pp.27-34,  2011-03-10.  金沢大学環日本海域環境研究センター = Kanazawa University Institute of Nature and Environmental Technology
URL: http://hdl.handle.net/2297/30435
93.

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唐, 寧 ; 小操, 征司 ; 渡辺, 有梨 ; 田畑, 勝弘 ; 鳥羽, 陽 ; 木津, 良一 ; 早川, 和一
出版情報: 日本海域研究所報告 = Bulletin of the Japan Sea Research Institute, Kanazawa University.  33  pp.77-86,  2002-03-13.  金沢大学日本海域研究所 = The Japan Sea Research Institute Kanazawa University Kakuma-machi, Kanazawa, Japan
URL: http://hdl.handle.net/2297/19878
94.

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鈴木, 信雄 ; 服部, 淳彦 ; 早川, 和一
出版情報: 年報 金沢大学環日本海域環境研究センター = K-INET Kanazawa University.  平成20年度  pp.86-87,  2010-01-29.  金沢大学環日本海域環境研究センター = Institute of Nature and Environmental Technology, Kanazawa University, Japan
URL: http://hdl.handle.net/2297/30164
概要: [研究報告]
95.

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山田, 丸 ; 岩坂, 泰信 ; 石, 広玉 ; 松木, 篤 ; Trochkine, Dmitri ; 張, 代洲 ; 長谷, 正博 ; 長谷, 徹志 ; 沈, 志宝 ; 早川, 和一
出版情報: 金沢大学自然計測応用研究センター年報.  2005  pp.76-77,  2005-01-01.  金沢大学自然計測応用研究センター
URL: http://hdl.handle.net/2297/6893
96.

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谷内口, 孝治 ; 松本, 典子 ; 羽賀, 雄紀 ; 鈴木, 元治 ; 松村, 千里 ; 鶴川, 正寛 ; 奥野, 俊博 ; 中野, 武 ; 川部, 季美 ; 鳥羽, 陽 ; 早川, 和一 ; 服部, 淳彦 ; 鈴木, 信雄
出版情報: 金沢大学環日本海域環境研究センター臨海実験施設研究概要・年次報告= Annual Report of Noto Marine Laboratory Institute of Nature and Environmental Technology, Kanazawa University.  10  pp.15-17,  2012-01-01.  金沢大学環日本海域環境研究センター臨海実験施設
URL: http://hdl.handle.net/2297/45454
97.

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川部, 季美 ; 鈴木, 信雄 ; 早川, 和一
出版情報: 金沢大学環日本海域環境研究センター臨海実験施設研究概要・年次報告= Annual Report of Noto Marine Laboratory Institute of Nature and Environmental Technology, Kanazawa University.  10  pp.18-19,  2012-01-01.  金沢大学環日本海域環境研究センター臨海実験施設
URL: http://hdl.handle.net/2297/45456
98.

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松本, 典子 ; 鈴木, 信雄 ; 笹山, 雄一 ; 早川, 和一
出版情報: 金沢大学環日本海域環境研究センター臨海実験施設研究概要・年次報告= Annual Report of Noto Marine Laboratory Institute of Nature and Environmental Technology, Kanazawa University.  10  pp.21-21,  2012-01-01.  金沢大学環日本海域環境研究センター臨海実験施設
URL: http://hdl.handle.net/2297/45460
99.

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鈴木, 信雄 ; 服部, 淳彦 ; 早川, 和一
出版情報: 金沢大学環日本海域環境研究センター臨海実験施設研究概要・年次報告= Annual Report of Noto Marine Laboratory Institute of Nature and Environmental Technology, Kanazawa University.  7  pp.14-15,  2009-01-01.  金沢大学環日本海域環境研究センター臨海実験施設
URL: http://hdl.handle.net/2297/42993
100.

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早川, 和一
出版情報: 金沢大学サテライトプラザミニ講演記録.  9  2008-09-27.  金沢大学地域連携推進センター
URL: http://hdl.handle.net/2297/12183
概要: 東アジアは世界でも産業経済が急激に発展している地域です。日本海を囲む日本及び中国,韓国,ロシアの4カ国のみで現在,世界のエネルギー消費量の1/4以上を占めて います。しかし,大量の化石燃料の燃焼により酸性雨や粉じん汚染,黄砂の飛来,あるいは タンカーの油流出事故等,無視できない環境問題を発生しています。演者が現 在,国際共同研究として取り組んでいるこの地域の大気・水環境問題の現状と日本の 役割について考えてみましょう。<br />年月日:2008年9月27日(土)2時~3時30分, 場所:金沢大学サテライト・プラザ 講義室 続きを見る