1.

図書

図書
Kazuichi Hayakawa ... [et al.], editors
出版情報: New York : Nova Science Publishers, c2018
シリーズ名: Environmental research advances series
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2.

図書

図書
Kazuichi Hayakawa, editor
出版情報: Singapore : Springer, c2018
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3.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2005.3
シリーズ名: 科学研究費補助金(基盤研究(B)(2))研究成果報告書 ; 平成15年度~平成16年度
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4.

図書

図書
田崎和江・早川和一(編著)
出版情報: 金沢 : 金沢大学21世紀COEプログラム, 2006.12
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図書
editorial supervisor, Kazuichi Hayakawa ; editors, Ning Tang ... [et al.]
出版情報: Tokyo : Maruzen, c2006
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図書
早川, 和一 ; 木津, 良一(1955-) ; 鎌田, 直人(1962-)
出版情報: Kanazawa : Kanazawa University, c2004
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7.

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宮崎元一,早川和一共著
出版情報: 東京 : 南江堂, 1986.10
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8.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2004.3
シリーズ名: 科学研究費補助金(基盤研究(B)(2))研究成果報告書 ; 平成14年度~15年度
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9.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 2001.3
シリーズ名: 科学研究費補助金(基盤研究(B)(1))研究成果報告 ; 平成10年度〜12年度
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10.

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図書
中島憲一郎, 早川和一編
出版情報: 東京 : 南山堂, 2000.1
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11.

図書

図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1998.3
シリーズ名: 科学研究費補助金基盤研究(C)(2)研究成果報告書 ; 平成8〜9年度
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12.

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図書
研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1992.3
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13.

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研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1996.3
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研究代表者 早川和一
出版情報: [金沢] : [早川和一], 1996.3
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15.

論文

論文
小村, 和久 ; 稲垣, 美幸 ; 西川, 方敏 ; 中西, 孝 ; 早川, 和一 ; 唐, 寧 ; 楊, 小陽 ; 飯田, 孝夫 ; 森泉, 純 ; Komura, Kazuhisa ; Inagaki, Miyuki ; Nishikawa, Katatoshi ; Hayakawa, Kazuichi ; Tang, Ning ; Yang, Xiaoyang ; Iida, Takao ; Moriizumi, Jyun
出版情報: 地球科学 = Earth Science.  61  pp.335-342,  2007-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00063583
概要: 金沢大学環日本海域環境研究センター<br />Variations of radiation levels before and after the Noto Hanto Earthquake in 2007 have been analy zed from the point of view of environmental radioactivity. The 210Pb activities in the airborne particles are collected from Nishi-Futamata in Wajima, are analyzed. The Radon activity at Hegura Island located 50km North of Wajima, and the spatial gamma rays at Nishi-Futamata are measured since April 21, 2007. Abnormal increase of 210Pb activity started 3 weeks before the earthquake are found, suggesting the maximum value just before the earthquake, because it decrease to normal level after 2 weeks. Increase of radon level was not observed at Hegura Island, however, increase of radiation level at Nishi-Futamata area continued for 6 weeks after the earthquake, and settled to normal level in middle of May 2007.<br />環境放射能の観点から能登半島地震発生前後の放射能関連のデータの解析を試みた.解析したのは,輪島市西二又地区で採取した大気浮遊塵中の210Pb,輪島沖50kmに位置する舳倉島のラドン濃度,地震発生後の4月21日から西二又地区で連続測定を実施した空間γ線レベルの3項目である.その結果,地震発生約3週間前から大気浮遊塵試料のラドンの娘核種210Pbの濃度が増加し,地震直前にピークに達した後に低下に転じ,約2週間後にほぼ平常値に回復していたことが分かった.舳倉島のラドンには地震の影響は見られなかったが,西二又における空間γ線レベルはラドンに由来すると考えれる高い値が約6週間後も続き5月中頃に平常値に戻ったことが明らかになった. 続きを見る
16.

論文

論文
Hayakawa, Kazuichi ; Miyoshi, Yasuko ; Kurimoto, Hiroaki ; Matzushima, Yuko ; Takayama, Nariaki ; Tanaka, Seishi ; Miyazaki, Motoichi ; 早川, 和一 ; 三好, 裕子 ; 栗本, 博昭 ; 松島, 優子 ; 高山, 成明 ; 田中, 星司 ; 宮崎, 元一
出版情報: Biological and Pharmaceutical Bulletin.  16  pp.817-821,  1993-09-15.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063584
概要: 金沢大学理工研究域自然システム学系<br />A HPLC determination method for methamphetamine (MA) and its metabolites in the urine samples of abusers has been developed. MA, amphetamine (AP), norephedrine (NE), p-hydroxymethamphetamine (pOHMA), p-hydoroxyamphetamine (pOHAP) and an internal standard, namely β-phenylethylamine (PEA) were derivatized with dansyl chloride. They were separated on a reversed phase column with gradient elution using an acetonitrile/tetrahydrofuran/imidazole buffer mobile phase and chemilumigenically determined using bis(2, 4, 6-trichlorophenyl)-oxalate/hydrogen peroxide as post column reagents. The lower determination limits were as low as 1×10-14-3×10-14mol. AP, NE, pOHAP and PEA were derivatized with naphthalene-2, 3-dicarboxaldehyde, and were separated on a reversed phase column using an acetonitrile/imidazole buffer mobile phase and chemilumigenically determined. The lower determination limits were 3×10-16-1.5×10-15mol. Enzymatic hydrolysis of glucuronides of pOHMA (pOHMAG) and pOHAP (pOHAPG) allowed them to be determined as pOHMA and pOHAP, respectively. After adjusting the pH of the urine samples to 10.5 and adding PEA, all metabolites except glucuronides were extracted quantitatively into chloroform-isopropanol (3 : 1). Utilizing the two methods, MA and all metabolites were determined in urine samples of MA abusers. The tendency, in order of decreasing concentration was : [MA]>[A]>[pOHMAG]>[pOHMA]>[NE]>[pOHAPG]>[pOHAP]. Although ephedrine (EP) was detected in several samples, it was not considered to be a metabolite of MA but rather a component derived from cough medicine. 続きを見る
17.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  45  pp.797-801,  2009-08-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063588
概要: 金沢大学理工研究域自然システム学系
18.

論文

論文
山本, 敦 ; 早川, 和一 ; Yamamoto, Atsushi ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  34  pp.34-38,  1998-01-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063589
概要: 金沢大学理工研究域自然システム学系
19.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ファルマシア = Farumashia くすりの科学.  40  pp.195-197,  2004-03-01.  Pharmaceutical Society of Japan 日本薬学会
URL: http://hdl.handle.net/2297/00063590
概要: 金沢大学理工研究域自然システム学系
20.

論文

論文
後藤, 純雄 ; 峯木, 茂 ; 杉田, 和俊 ; 遠藤, 治 ; 村山, 留美子 ; 内山, 巌雄 ; 田中, 基裕 ; 早川, 和一 ; Goto, Sumio ; Mineki, Shigeru ; Sugita, Kazutoshi ; Endo, Osamu ; Murayama, Rumiko ; Uchiyama, Iwao ; Tanaka, Motohiro ; Hayakawa, Kazuichi
出版情報: 環境化学 = Journal of Environmental Chemistry.  7  pp.553-559,  1997-09-12.  環境化学研究会 Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/00063597
概要: 金沢大学理工研究域自然システム学系<br />ナホトカ号から流出し日本海沿岸に漂着した重油の汚染状況を把握するための調査研究の一環として, 平成9年1月16日に採取した漂着重油, ナホトカ号船首部分の重油および市販C重油中に含まれる多環芳香 族炭化水素 (PAH) の分析及び抽出物の変異原性を測定した。その結果, 漂着重油のベンゾ (a) ピレン (BaP) 含有量は1984年に採取された東京都市部の土砂51試料の平均値の約1/4であることやその変異原比活性は同土砂の約4倍であることなどを認めた。<br />As a part of research studies on the pollution at heavy-oil coated parts of the Sea of Japan coastline, resulting from the wrecked Russian tanker Nakhodka on Jan. 2, the following experiments were performed using three heavy oil samples. Polycyclic aromatic hydrocarbons (PAH) were analyzed by HPLC in the heavy oil that washed ashore, which was collected at Mikuni-cho in Fukui Prefecture on Jan. 16, 1997, heavy oil in the oil compartment of the bow of the tanker, and commercial heavy oil (class C) .Mutagenicities of the extracts of these oil samples were also measured. The amount of benzo (a) pyrene (BaP) contained in the heavy oil that washed ashore was about a quarter of the average in 51 soil extracted samples, which were collected at an urban area in Tokyo in 1984, and mutagenicity of the extract from the oil was about 4-fold higher than the average in the extracts from the soil samples. 続きを見る
21.

論文

論文
佐川, 岳人 ; 西, 香菜子 ; 納富, 美穂 ; 平岡, 龍之 ; 塚本, 和巳 ; 早川, 和一 ; Sagawa, Takehito ; Nishi, Kanako ; Notomi, Miho ; Hiraoka, Tatsuyuki ; Tsukamoto, Kazumi ; Hayakawa, Kazuichi
出版情報: 日本食品科学工学会誌 = Nippon Shokuhin Kagaku Kogaku Kaishi.  58  pp.222-228,  2011-05-15.  日本食品科学工学会 Journal of the Japanese Society for Food Science and Technology
URL: http://hdl.handle.net/2297/00063602
概要: 金沢大学理工研究域自然システム学系<br />生スィートバジルを乾燥する際に引き起こされる香りの変化を,香気成分バランスやスィートバジルの組織構造とそのレオロジー特性について,比較解析を行う事で,生スィートバジルの香りを維持する為に必要とさ れる因子の探索を行った.スィートバジルの香気寄与成分として特定したシネオール,リナロール,オイゲノール,オクタナール,1-オクタノール,(E)-2-ヘキセナール,(Z)-3-ヘキセノールの7種類の香気成分は官能評価の特徴を説明する因子となると考えられる.その中でも,生スィートバジルの香りを特徴づける因子としては,微量成分バランスが大きな役割を果たし,ハーブ自体には (E)-2ヘキセナールや (Z)-3-ヘキセノールが存在するが,それがハーブティーに溶出されずオクタナールが高い比率で溶出されることが重要であった.そのような性質を持つ組織構造は,葉内部の細胞壁の形状が乾燥工程を経ても維持されており,その状態は貯蔵弾性率の測定でも比較説明が可能であることが明らかになった.これらの結果により,ハーブの組織構造とハーブティーとして溶出される香気成分バランスに密接な関係がある可能性が示唆された.但し,今回確認された (E)-2-ヘキセナールや (Z)-3-ヘキセノールはみどりの香りと称される物質の1つである.これらの物質は植物中のリノレン酸や配糖体を前駆体として酵素が関与し発現するものであり12),食品加工時に発生することも知られている14)~16) .今後は配糖体量の変化と酵素の関係についても検討を行い,組織構造変化の香りに対する影響をより明確にしてゆく必要があると考える.しかしながら,細胞壁の損傷が少ない状態であった真空乾燥スィートバジルが生特有の香りを保持していたという事実から,乾燥工程を経ることで喫食時に感じる香りの違いは,単純な香気成分の増減という因子だけではなく,組織構造変化という因子からも説明できる可能性が示唆された.乾燥ハーブの香りに対する品質評価を行う上で,乾燥ハーブからハーブティーに抽出されてゆく香気成分のバランス変化や内部組織構造変化の比較といった多面的なアプローチは,今後の有効な評価手法の1つとなることが期待できる.<br />A quality evaluation method for dried herbs was studied with sweet basil leaves (fresh, air-dried, freeze-dried and vacuum-dried sweet basil leaves) as herbal teas, involving hot-water extraction. Sensory evaluation revealed that the flavor of herbal tea with vacuum-dried sweet basil leaves was similar to that with fresh leaves. Seven odor-active compounds (cineole, linalool, eugenol, octanal, 1-octanol, (E)-2-hexenal and (Z)-3-hexenol) from herbal teas were identified by capillary gas chromatographic-mass spectrometry and olfactometry analysis, and it was considered that three compounds (octanal, (E)-2-hexenal and (Z)-3-hexenol) were key compounds for describing the results of sensory evaluation. The structure of dried sweet basil leaves with water-absorption and fresh leaves was observed by differential interference contact microscopy, and their rheological characteristics were measured for storage modulus. As a result, the characteristics of vacuum-dried sweet basil were similar to those of fresh basil. These results suggest that investigation of the aroma using hot-water extraction, tissue structure and rheological characteristics could be effective approaches to qualitatively evaluate dried herbs. 続きを見る
22.

論文

論文
神山, 和夫 ; 小池, 益人 ; 平尾, 宜司 ; 鳥羽, 陽 ; 早川, 和一 ; Koyama, Kazuo ; Koike, Masuhito ; Hirao, Takashi ; Toriba, Akira ; Hayakawa, Kazuichi
出版情報: 日本食品工学会誌 = Japan Journal of Food Engineering.  13  pp.43-49,  2012-09-15.  日本食品工学会 Japan Society for Food Engineering
URL: http://hdl.handle.net/2297/00063603
概要: 金沢大学理工研究域自然システム学系<br />製造工程中に起きるデンプンの部分糊化が,レトルトカレーの最終粘度に及ぼす影響を調べた.レトルトカレーの粘度は,煮込みとそれに続くレトルト殺菌工程で,原料中のデンプンが糊化することで上昇する.しか し,煮込み工程前の原料混合工程の温度が高過ぎると,最終粘度が十分に上昇しないことが経験的にわかっている.そこで,原料混合工程の温度とデンプンの糊化状態をアミロース溶出度,膨潤度,動的粘弾性および示差走査熱量分析から調べ,最終粘度との関係を考察した.その結果,原料混合工程の温度が65℃以上であると,デンプンの部分糊化が起こるため,その後の煮込み工程と殺菌工程での粘度上昇は抑制されることがわかった.<br />The effect of partial gelatinization of starch during precooking operation on the final viscosity of retort curry at serving temperature was investigated. While the increase in the viscosity of retort curry is largely due to the starch gelatinization during the heating processes of cooking and sterilization, it is known empirically that a high temperature during the material mixing operation before cooking may result in a lower final viscosity. The relationship between the temperature and the partial starch gelatinization during material mixing was therefore studied by measuring amylose leaching, swelling ratio, dynamic viscoelasticity, and by differential scanning calorimetry (DSC). When the mixing temperature was at or higher than 65℃, the starch was partially gelatinized under the low water condition, and as the result, the increase in the viscosity during cooking and sterilization was suppressed. This finding is expected to be useful in controlling the viscosity of starch-containing retort foods. 続きを見る
23.

論文

論文
鳥羽, 陽 ; 笠原, 千栄子 ; 戸次, 加奈江 ; 佐溝, 将之 ; 唐, 寧 ; 早川, 和一 ; Toriba, Akira ; Kasahara, Chieko ; Bekki, Kanae ; Samizo, Masayuki ; Ning, Tang ; Hayakawa, Kazuichi
出版情報: 分析化学 = BUNSEKI KAGAKU.  68  pp.839-845,  2019-11-05.  日本分析化学会 The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/00063604
概要: 金沢大学理工研究域自然システム学系<br />大気中の粒子状物質(PM)中の水酸化多環芳香族炭化水素(OHPAH)を定量することを目的とするGC/MSによる分析法を開発した.母核の環数が2〜4環のOHPAH 10種を分析対象とし,トリメチル シリル(TMS)誘導体化したうえで検出し,3種類の重水素化,または安定同位体標識化OHPAHを内部標準物質として用いてPM試料の定量に適用した.OHPAHのTMS誘導体の選択イオン検出(SIM)における検出限界(S/N=3)は,12〜930 fgの範囲で,すべての分析対象物質について10.5分で分離・検出することができた.都市大気標準粉じんや金沢で捕集したPM試料はジクロロメタンで抽出したのち,シリカゲル固相により精製しTMS誘導体化して定量した.金沢で捕集したPM試料中の8種のOHPAHを定量することに成功し,それらの濃度範囲は,20〜4100 fg m−3であり,3-hydroxyfluorantheneのPM中濃度の報告は本研究が初めてである.確立した分析法は,大気粉じん中のOHPAHを定量する際の分析法の選択肢の一つとして有用である.<br />A GC/MS method was developed for the quantification of hydroxylated polycyclic aromatic hydrocarbons (OHPAHs) in airborne particulate matter (PM). Ten OHPAHs having 2 - 4 rings were detected after trimethylsilyl (TMS) derivatization, and the derivatives in PM samples were quantified with three kinds of deuterated or stable isotope labeled OHPAHs as internal standards. The detection limits (S/N = 3) of the derivatives of OHPAHs in the selected ion monitoring (SIM) mode ranged from 12 to 930 fg and all analytes were separated and detected within 10.5 min. A commercially available urban PM sample and PM samples collected in Kanazawa were extracted with dichloromethane, and then the extracts were purified with silica gel solid phase and derivatized OHPAHs in the extracts were quantified. We successfully quantified 8 OHPAHs in PM samples collected in Kanazawa, and their concentrations were in the range of 20 - 4100 fg m−3 and the levels of 3-hydroxyfluoranthene were reported for the first time. This method should be useful as an optional analytical method to quantify OHPAHs in PM samples. 続きを見る
24.

論文

論文
Bekki, Kanae ; Toriba, Akira ; Ning, Tang ; Kameda, Takayuki ; Hayakawa, Kazuichi ; 戸次, 加奈江 ; 鳥羽, 陽 ; 唐, 寧 ; 亀田, 貴之 ; 早川, 和一
出版情報: Journal of UOEH = 産業医科大学雑誌.  35  pp.17-24,  2013-03-01.  産業医科大学 University of Occupational and Environmental Health
URL: http://hdl.handle.net/2297/00063611
概要: 金沢大学理工研究域自然システム学系<br />Polycyclic aromatic hydrocarbons (PAHs) are included in various environmental pollutants such as airborne particles and have been reported to induce a variety of toxic effects. On the other hand, PAH derivatives are generated from PAHs both through chemical reaction in the atmosphere and metabolism in the body.PAH derivatives have become known for their specific toxicities such as estrogenic/antiestrogenic activities and oxidative stress, and correlations between the toxicities and structures of PAH derivatives have been shown in recent studies. These studies are indispensable for demonstrating the health effects of PAH derivatives, since they would contribute to the comprehensive toxicity prediction of many kinds of PAH derivatives.<br />多環芳香族炭化水素類(PAHs)は大気粉塵などの多種類の環境汚染物質に含まれ,長年の研究によって多様な生体影響を引き起こすことが知られている.一方で,PAHsは生体内での代謝反応や,大気中での化学反応によって多種多様な誘導体を生成することが知られている.近年では,PAHだけでなくPAH誘導体の毒性影響が着目されており,エストロゲン様/抗エストロゲン作用,酸化ストレス反応など,PAHとは異なる誘導体独自の毒性影響の存在が報告されている.また,生成するPAH誘導体には多くの構造異性体が存在するが,PAH誘導体が示す毒性作用と構造との間に相関性,いわゆる構造活性相関があることが示されている.以上の研究は,環境中に存在するPAH 誘導体の生体影響を解明する上で重要な研究であるとともに,多種多様なPAH誘導体の総合的な毒性影響予測に貢献できると考えられる. 続きを見る
25.

論文

論文
中澤, 章 ; 唐, 寧 ; 井上, 嘉則 ; 上茶谷, 若 ; 加藤, 敏文 ; 齊藤, 満 ; 小原, 健嗣 ; 鳥羽, 陽 ; 早川, 和一 ; Nakazawa, Akira ; Ning, Tang ; Inoue, Yoshinori ; Kamachitani, Waka ; Katoh, Toshifumi ; Saito, Mitsuru ; Obara, Kenji ; Toriba, Akira ; Hayakawa, Kazuichi
出版情報: Journal of UOEH = 産業医科大学雑誌.  39  pp.69-74,  2017-03-01.  産業医科大学 University of Occupational and Environmental Health
URL: http://hdl.handle.net/2297/00063612
概要: 金沢大学理工研究域自然システム学系<br />著者らが開発した繊維状吸着材(DAM不織布)は,両性イオン型高分子であるジアリルアミン‐マレイン酸共重合体(diallylamine-maleic acid copolymer: DAM)を含有 し,繊維表面に水和層を形成する.本研究では,悪臭物質の一つである半揮発性有機酸(C1-C5)を対象に水溶液だけでなくガス状でもDAM不織布の吸着特性評価を行った.まず,水溶液中のギ酸はDAM不織布の水和層へ溶解した後,DAMのイミノ基との静電相互作用で吸着することがわかった.一方ガス状では,ギ酸,プロピオン酸,酪酸,吉草酸,イソ吉草酸について高い吸着能を有し,吸着量は曝露時間に依存して増加する傾向があった.ガス状有機酸に対する吸着も水溶液と同様の機序で生じていると考えられるが,さらに酢酸を除く有機酸の吸着速度定数と空気 / 水分配係数(log Kaw)が良好な相関性を有したことから,DAM不織布は大気中から不織布表面に形成される水和層へ移行性が高い親水性化合物に対するほど高い選択性をもつことが示された.<br />Diallylamine-maleic acid copolymer (DAM)-nonwoven fabric (DAM-f), a fibrous adsorbent, contains DAM with zwitter-ionic functional groups and forms a hydration layer on the surface. The aim of this report was to evaluate the adsorption selectivity of DAM-f to semi-volatile organic acid (C1-C5). In the aqueous phase, formic acid dissolved in the hydration layer bound to the imino group of DAM-f due to anion exchange interaction. In the gas phase, the adsorption amounts of organic acids increased with the exposure time. Moreover, the adsorption rate constants correlated with the air/water partition coefficients (log Kaw) for formic acid, propionic acid, butyric acid, valeric acid and isovaleric acid, except for acetic acid. These results indicate that DAM-f is highly selective to hydrophilic compounds which easily move from the air to the hydration layer of DAM-f. 続きを見る
26.

論文

論文
早川, 和一 ; 加賀谷, 重浩 ; Hayakawa, Kazuichi
出版情報: ぶんせき.  456  pp.724-726,  2012-12-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48486
27.

論文

論文
早川, 和一 ; 唐, 寧 ; 鳥羽, 陽 ; 亀田, 貴之 ; Hayakawa, Kazuichi ; Ning, Tang ; Toriba, Akira ; Kameda, Takayuki
出版情報: ぶんせき.  402  pp.278-284,  2008-06-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48485
概要: 東アジア地域では,急速な産業発展に伴って,環境問題も深刻化している。本稿では,筆者(早川)が拠点リーダーを務め平成14~18 年度にわたって実施した文部科学省21世紀COE プログラム「環日本海域の環境計測と長期・短期変動予測」の研究成果を 含め,東アジアの有害大気汚染物質としてクローズアップされている多環芳香族炭化水素とニトロ多環芳香族炭化水素に焦点を合わせて,分析化学研究の現状を紹介し,今後の課題について展望する。 続きを見る
28.

論文

論文
小玉, 修嗣 ; 早川, 和一 ; Kodama, Shuji ; Hayakawa, Kazuichi
出版情報: ぶんせき.  303  pp.167-168,  2000-03-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48484
29.

論文

論文
早川, 和一 ; Hayakawa, Kazuichi
出版情報: ぶんせき.  268  pp.323-327,  1997-04-05.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48483
30.

論文

論文
早川, 和一 ; 山本 , 敦 ; 宮崎, 元一 ; Hayakawa, Kazuichi ; Yamamoto, Atsushi ; Miyazaki, Motoichi
出版情報: ぶんせき.  197  pp.358-363,  1991-05-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48481
31.

論文

論文
早川, 和一 ; 宮崎, 元一 ; Hayakawa, Kazuichi ; Miyazaki, Motoichi
出版情報: ぶんせき.  193  pp.47-53,  1991-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/48480
32.

論文

論文
Higashi, Tomomi ; Ohkura, Noriyuki ; Fujimura, Masaki ; Nakai, Satoshi ; Honda, Yasushi ; Saijoh, Kiyofumi ; Hayakawa, Kazuichi ; Kobayashi, Fumihisa ; Michigami, Yoshimasa ; Olando, Anyenda Enoch ; Hitomi, Yoshiaki ; Nakamura, Hiroyuki ; 東, 朋美 ; 大倉, 徳幸 ; 藤村, 政樹 ; 西條, 淸史 ; 早川, 和一 ; 小林, 史彦 ; 道上, 義正 ; 人見, 嘉哲 ; 中村, 裕之
出版情報: Atmospheric Environment.  97  pp.544-551,  2014-11-01.  Elsevier Ltd
URL: http://hdl.handle.net/2297/00049597
概要: 金沢大学医薬保健研究域医学系<br />Asian dust, known as kosa in Japanese, is a major public health concern. In this panel study, we eva luated the effects of exposure to kosa on daily cough occurrence. The study subjects were 86 patients being treated for asthma, cough variant asthma, or atopic cough in Kanazawa University Hospital from January 2011 to June 2011. Daily mean concentrations of kosa and spherical particles were obtained from light detection and ranging (LIDAR) measurements, and were categorized from Grade 1 (0 μg/m3) to 5 (over 100 μg/m3). The association between kosa and cough was analyzed by logistic regression with a generalized estimating equation. Kosa effects on cough were seen for all Grades with potential time lag effect. Particularly at Lag 0 (the day of exposure), a dose-response relationship was observed: the odds ratios for Grades 2, 3, 4, and 5 above the referent (Grade 1) were 1.111 (95% confidence interval (CI): 0.995-1.239), 1.171 (95% CI: 1.006-1.363), 1.357 (95% CI: 1.029-1.788), and 1.414 (95% CI: 0.983-2.036), respectively. Among the patients without asthma, the association was higher: the odds ratios for Grades 2, 3, 4 and 5 were 1.223 (95% CI: 0.999-1.497), 1.309 (95% CI: 0.987-1.737), 1.738 (95% CI: 1.029-2.935) and 2.403 (95% CI: 1.158-4.985), respectively. These associations remained after adjusting for the concentration of spherical particles or particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5). Our findings demonstrate that kosa is an environmental factor which induces cough in a dose-response relationship. © 2014 Elsevier B.V.<br />Embargo Period 12 months 続きを見る
33.

その他

その他
金沢大学フロンティアサイエンス機構 ; 早川, 和一 ; 太田, 富久 ; 池本, 良子 ; Hayakawa, Kazuichi ; Ohta, Tomihisa ; Ikemoto, Ryoko
出版情報: FSO Newsletter = Frontier Science Organization Newsletter.  8  pp.11-11,  2011-11-01.  金沢大学フロンティアサイエンス機構 = Frontier Science Organization Kanazawa University
URL: http://hdl.handle.net/2297/30125
34.

論文

論文
戸次, 加奈江 ; 滝上, 英孝 ; 鈴木, 剛 ; 唐, 寧 ; 鳥羽, 陽 ; 亀田, 貴之 ; 早川, 和一
出版情報: 環境化学 = journal of environmental chemistry.  21  pp.27-33,  2011-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39396
概要: Polycyclic aromatic hydrocarbons (PAHs) and dioxins have several toxic properties, including mutagenicity, carcinogenici ty and reproductive toxicity. PAHs mainly originate from the burning of petroleum and coal, while dioxins originate mainly from waste incineration and agrochemicals. Both PAHs and dioxins have aryl hydrocarbon receptor (AhR) binding activity which is related to toxicity of PAHs and dioxins. In this study, we evaluated AhR binding activity of airborne particles collected in Beijing, China and Kanazawa, Japan by DR-CALUX and the contribution of PAHs and dioxins to this activity. AhR binding activity of airborne particles in Beijing (1,200 ng • m-3) was four hundred times higher than in Kanazawa (2.7 ng • m-3). The composition of PAHs didn′t show large difference in Beijing and Kanazawa. The contribution of the PAHs to CALUX-TEQ was higher than dioxins and especially high in Kanazawa (10.4 %). These results suggest that PAHs show large contribution to the toxicity of airborne particles, and other kinds of PAH and PAH related compounds will also contribute to that toxicity. The difference of concentration and composition of these compounds result in the different level of toxicity of airborne particles in each city. 続きを見る
35.

論文

論文
早川, 和一 ; 木津, 良一 ; 安藤, 京子 ; 村橋, 毅 ; 東, 成見 ; 山本, 茂樹 ; 長谷川, 幸司 ; 中浜, 慶子 ; 山下, 克美 ; 松本, 健 ; 後藤, 純雄
出版情報: 環境化学 = journal of environmental chemistry.  7  pp.545-552,  1997-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39393
概要: 「ナホトカ号」から抜き取った重油, 環境試料 (大気, 漂着重油, 海水) 中の芳香族成分をGC/MS, 蛍光検出HPLCで定着した。重油からはベンゼン, トルエン, エチルベンゼン, キシレン, ナフタレン, アセナフテン, フルオレン, アントラセン, フルオランテン, ピレン, ベンツ [a] アントラセン, クリセン, ベンゾ [b] フルオランテン, ベンゾ [k] フルオランテン, ベンゾ [a] ピレン, ジベンツ [a, h] アントラセン, ベンゾ [ghi] ペリレンが検出された。 大気中ベンゼン, トルエン, キシレン, ナフタレン濃度は有毒なレベルより遥かに低かった。しかし, モデル実験から重油流出直後はベンゼン, トルエン, キシレン, ナフタレン濃度は高いことが推定された。漂着重油中のナフタレン濃度は低下傾向が認められたが, ピレン, ベンゾ [a] ピレン濃度はほとんど同じであった。ナフタレンの減少は揮散のためと考えられた。また, 海岸砂中の多環芳香族炭化水素類の組成は漂着重油中のそれと類似していた。ベンゾ [a] ピレンの海水中濃度は低下傾向を示した。 重油の変異原性, DNA損傷についても調べた。重油はSalmonella typhimurium TA98及びTA100株に対し間接変異原性を示した。また, 重油で処理するとヒトFL細胞中でp53遺伝子を活性化させることから, DNA損傷を引き起こすことが明らかとなった。 Aromatic hydrocarbons in the oil spilled from“the Nakhodka”and in the environmental samples including air, reached oil and sea water were determined by gas chromatography/mass spectrometric detection and high-performance liquid chromatography/fluorescence detection. Aromatic hydrocarbons determined in the oil were as follows: benzene, toluene, ethylbenzene, xylenes, naphthalene, acenaphthene, fluorene, anthracene, fluoranthene, pyrene, benz [a] anthracene, chrysene, benzo [b] fluoranthene, benzo- [k] fluoranthene, benzo [a] pyrene, dibenz [a, h] anthracene and benzo [ghi] perylene. Concentrations of benzene, toluene, xylenes and naphthalene in the air collected at contaminated seashores were much lower than their toxic levels. However, a model experiment suggested that their concentrations in the air might be higher just after the oil spill. Although the naphthalene concentration in the reached oil samples tended to decrease with time, pyrene and benzo [a] pyrene concentrations were relatively constant. The decrease in naphthalene concentration in the reached oil samples was considered to be due to vaporization. Benzo [a] pyrene concentrations in sea water tended to decrease with time. The mutagenicity and DNA damage of the oil were assayed. The oil showed indirectacting mutagenicity in the Salmonella typhimurium TA98 and TA100 strains in the presence of S9 mix. Production of p53 protein was enhanced in human FL cells after the treatment with the oil, indicating that the oil caused DNA damage. 続きを見る
36.

論文

論文
早川, 和一 ; 今泉, 範子
出版情報: 水質汚濁研究 = Japan journal of water pollution research.  11  pp.79-82,  1988-01-01.  水環境学会 = Japan Society on Water Environment
URL: http://hdl.handle.net/2297/39387
37.

論文

論文
岸田, 真男 ; 今村, 清 ; 亀田, 貴之 ; 早川, 和一 ; 坂東, 博
出版情報: 環境化学 = journal of environmental chemistry.  20  pp.173-181,  2010-01-01.  日本環境化学会 = Japan Society for Environmental Chemistry
URL: http://hdl.handle.net/2297/39404
概要: A determination method of atmospheric oxygenated polycyclic aromatic hydrocarbons (Oxy-PAHs) in particulate matter and t he gaseous phase using gas chromatograph (GC)-mass spectrometer (MS) was studied in the present study. First, we obtained fundamental data of GC-MS analyses (mass spectra and calibration curves) of twelve Oxy-PAHs as follows: acenaphthenequinone (AceQ), 1,4-naphtoquinone (1,4-NQ), 9-fluorenone (9-F-one), 1,4-phenanthrenequinone (1,4-PQ), 1,4-, 9,10-anthaquinone (1,4-, 9,10-AQ), 1-hydroxyanthrquinone (1-OHAQ), 1,2-benzanthraquinone (1,2-BAQ), benz[c]phenanthrene[1,4]quinine (BcP-1,4Q), 3,4-dihydrobenzo[a]anthracene-1(2H)-one (BaA-one), 1,4-chrysenequinone (1,4-CQ) and 9,10-dihydrobenzo[a]pyrene-7(8H)-one (BaP-one). Subsequently, to evaluate collection efficiency of Oxy-PAHs, air was passed through a quartz-fiber filter (QFF) spiked with authentic Oxy-PAHs and then through cleaned polyurethane form (PUF) plugs using a mini-pump or a low-volume air sampler for 24 h in the dark at a constant room temperature (20 or 35 °C). Oxy-PAHs retained on the QFF and those trapped within PUF plugs were simultaneously Soxhlet extracted, purified with silica by gel column chromatography and determined using GC-MS. The calibration curves for the determination of the twelve Oxy-PAHs were proportional in the concentration range between 0.02 and 1.0 μg/mL with r2 values of 0.960-0.999. Among the twelve Oxy-PAH compounds examined, recoveries of six compounds (1,4-NQ, 9-F-one, 9,10-AQ, 1,2-BAQ, BaA-one and BaP-one) during sampling, Soxhlet-extraction and clean-up procedures sufficiently yielded 79-127% at a room temperature of 20 °C and 57-127% at 35 °C . The method detection limits (MDLs) of the six compounds ranged between 0.61-1.07 ng/m3. The proposed method was applied to the determination of the six Oxy-PAH compounds in the atmosphere. Air sample was collected at an urban location of Osaka, Japan for 12-13 February 2007. 1,4-NQ, 9-F-one and 9-F-one were detected in the sample at concentration level of approximately 0.7-3 ng/m3. 続きを見る
38.

論文

論文
戸次, 加奈江 ; 唐, 寧 ; 鳥羽, 陽 ; 早川, 和一
出版情報: 産業医科大学雑誌.  30  pp.39-45,  2008-03-01.  産業医科大学学会
URL: http://hdl.handle.net/2297/32486
概要: 大気中には様々な有機汚染物質が含まれている.そのうち多環芳香族炭化水素(PAH)およびニトロ多環芳香族炭化水素(NPAH)は,化石燃料などの燃焼に伴って発生し,ヒトの健康に影響をおよぼす物質である.環日本海域の4ヶ国,中国,ロシア,韓国,日 本は,主要エネルギーの種類や生活様式,産業構造や事業所の設備などが異なり,その結果大気汚染のレベルと中身も大きく異なると推定される.そこで,本報では中国と日本の製鉄業を中心とする都市である鉄嶺と北九州を選び大気粉塵を捕集後PAH,NPAH,変異原性,活性酸素種(ROS)生成能を測定し化学物質と毒性の点から比較評価を行った.PAH,NPAH濃度は中国で高濃度を示し,冬高夏低の傾向が見られた.また変異原性は冬に高いが,ROS生成能は夏に高くなる傾向が見られ,変異原性とROS生成能には異なる原因物質が関与すると考えられた.PAH,NPAHとは異なる化合物の寄与も大きいことが考えられた. Airborne participate matters contain many kinds of organic pollutants. Among them, polycyclic aromatic hydrocarbons (PAH), nitropolycyclic aromatic hydrocarbons (NPAH) and quinoid PAHs were reported to have several human health effects. We collected airborne particulates in Kitakyushu, Japan and Tieling, China in summer and winter, and analyzed the PAH and NPAH to evaluate the direct- and indirect-acting mutagenicities and generating activities of reactive oxygen species (ROS). The concentrations of PAHs and NPAHs in Tieling were much higher than in Kitakyushu, with seasonal variations. The mutagenicity level was higher in winter while the ROS generation activity was higher in summer. These results suggest that concentrations of PAH and NPAH didn' t correlate with mutagenicity and ROS generation activity. More studies are needed on the environmental behaviors of compounds other than PAHs and NPAHs, such as quinoid PAHs, and their biological activities. 続きを見る
39.

論文

論文
唐, 寧 ; 伊崎, 陽彦 ; 徳田, 貴裕 ; 季, 若男 ; 董, 麗君 ; 呉, 慶 ; 周, 志俊 ; 黄, 蓉 ; 林, 振宇 ; 亀田, 貴之 ; 鳥羽, 陽 ; 島, 正之 ; 早川, 和一
出版情報: 分析化学 = BUNSEKI KAGAKU.  62  pp.267-273,  2013-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/36937
概要: Urban air contains various kinds of organic pollutants. Among them, several polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are carcinogenic and/or endocrine disrupting. PAHs and NPAHs in the atmosphere mainly originate from imperfect combustion of organic matter, such as petroleum and coal. In this study, total suspended particles (TSP) were collected in three different particulate size fractions by using Andersen low-volume air samplers in Shenyang, Shanghai and Fuzhou, China, in the winter and summer seasons in 2010. Nine PAHs and twelve NPAHs in the extracts from the TSP were analyzed by HPLC with fluorescence detection and chemiluminescence detection, respectively. The mean concentrations of the sums of the nine PAHs and twelve NPAHs were highest in Shenyang and lowest in Fuzhou. In each city, more than 80% of the total PAHs and total NPAHs were found in the fine particulate fraction (<2.1 μm). All PAHs and NPAHs were clearly higher in the winter than in the summer. Furthermore, the ratio of the molar concentrations of 1-nitropyrene to pyrene ([1-NP]/[Pyr]), which is a suitable indicator to estimate the contribution of diesel-engine vehicles and coal combustion to urban TSP, were smaller in Shenyang in the winter. However, in Shanghai, Fuzhou and Shenyang (summer), the [1-NP]/[Pyr] ratios were close to those of particulates released from diesel-engine automobiles. Our study showed that the major contributors of atmospheric PAHs and NPAHs were diesel-engine vehicles both in the winter and the summer in Shanghai and Fuzhou, and in the summer in Shenyang. However, in the winter in Shenyang, atmospheric PAHs and NPAHs seemed to be affected by the mixture of coal combustion systems, such as coal heating and diesel-engine vehicles. 2010年の冬季及び夏季に中国の東部に位置する瀋陽,上海及び福州で総浮遊粒子状物質をアンダーセン式ローボリウムエアサンプラーを用いて粒径別(<2.1 μm,2.1~7 μm,>7 μm)に捕集した.強い発がん性または内分泌かく乱性を有する9種の多環芳香族炭化水素(PAH)と12種のニトロ多環芳香族炭化水素(NPAH)をそれぞれ高速液体クロマトグラフ(HPLC)蛍光検出法,HPLC化学発光検出法で分析した.その結果,3都市の大気中PAH,NPAH濃度はいずれも冬高夏低の季節変動を呈し,また季節によらず瀋陽で最も高く,福州で最も低いことが分かった.また3都市の大気中PAH,NPAHの80% 以上は呼吸器への沈着率の高い微小粒子画分(<2.1 μm)に存在した.さらに,大気中PAH,NPAHの主要発生源の識別マーカーであるピレンに対する1-ニトロピレン濃度比を3都市で比較した結果,上海,福州及び夏季の瀋陽の大気中PAH,NPAHの主要発生源がディーゼル車であり,冬季の瀋陽はディーゼル車と石炭暖房施設の両方であることが明らかになった. 続きを見る
40.

論文

論文
唐, 寧 ; 伊崎, 陽彦 ; 徳田, 貴裕 ; 季, 若男 ; 董, 麗君 ; 呉, 慶 ; 周, 志俊 ; 黄, 蓉 ; 林, 振宇 ; 亀田, 貴之 ; 鳥羽, 陽 ; 島, 正之 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  62  pp.267-273,  2013-01-01.  日本分析化学会
URL: http://hdl.handle.net/2297/43418
概要: Urban air contains various kinds of organic pollutants. Among them, several polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are carcinogenic and/or endocrine disrupting. PAHs and NPAHs in the atmosphere mainly originate from imperfect combustion of organic matter, such as petroleum and coal. In this study, total suspended particles (TSP) were collected in three different particulate size fractions by using Andersen low-volume air samplers in Shenyang, Shanghai and Fuzhou, China, in the winter and summer seasons in 2010. Nine PAHs and twelve NPAHs in the extracts from the TSP were analyzed by HPLC with fluorescence detection and chemiluminescence detection, respectively. The mean concentrations of the sums of the nine PAHs and twelve NPAHs were highest in Shenyang and lowest in Fuzhou. In each city, more than 80% of the total PAHs and total NPAHs were found in the fine particulate fraction (<2.1 μm). All PAHs and NPAHs were clearly higher in the winter than in the summer. Furthermore, the ratio of the molar concentrations of 1-nitropyrene to pyrene ([1-NP]/[Pyr]), which is a suitable indicator to estimate the contribution of diesel-engine vehicles and coal combustion to urban TSP, were smaller in Shenyang in the winter. However, in Shanghai, Fuzhou and Shenyang (summer), the [1-NP]/[Pyr] ratios were close to those of particulates released from diesel-engine automobiles. Our study showed that the major contributors of atmospheric PAHs and NPAHs were diesel-engine vehicles both in the winter and the summer in Shanghai and Fuzhou, and in the summer in Shenyang. However, in the winter in Shenyang, atmospheric PAHs and NPAHs seemed to be affected by the mixture of coal combustion systems, such as coal heating and diesel-engine vehicles. 2010年の冬季及び夏季に中国の東部に位置する瀋陽,上海及び福州で総浮遊粒子状物質をアンダーセン式ローボリウムエアサンプラーを用いて粒径別(<2.1 μm,2.1~7 μm,>7 μm)に捕集した.強い発がん性または内分泌かく乱性を有する9種の多環芳香族炭化水素(PAH)と12種のニトロ多環芳香族炭化水素(NPAH)をそれぞれ高速液体クロマトグラフ(HPLC)蛍光検出法,HPLC化学発光検出法で分析した.その結果,3都市の大気中PAH,NPAH濃度はいずれも冬高夏低の季節変動を呈し,また季節によらず瀋陽で最も高く,福州で最も低いことが分かった.また3都市の大気中PAH,NPAHの80% 以上は呼吸器への沈着率の高い微小粒子画分(<2.1 μm)に存在した.さらに,大気中PAH,NPAHの主要発生源の識別マーカーであるピレンに対する1-ニトロピレン濃度比を3都市で比較した結果,上海,福州及び夏季の瀋陽の大気中PAH,NPAHの主要発生源がディーゼル車であり,冬季の瀋陽はディーゼル車と石炭暖房施設の両方であることが明らかになった. 続きを見る
41.

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亀田, 貴之 ; 片山, 裕規 ; 後藤, 知子 ; 鳥羽, 陽 ; 唐, 寧 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  62  pp.979-984,  2013-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44505
概要: A simple and sensitive method for measuring quinoid polycyclic aromatic hydrocarbons (PAHQs) in soluble organic fraction (SOF) of airborne particles based on two-dimensional high-performance liquid chromatography (HPLC) with fluorescence detection was established. The system involves a reversed phase column with naphtylethyl groups bonded silica packing material for sample clean-up, a 6-port switching valve, an ODS column for trapping the fraction containing PAHQs, a reversed phase column with cholesteryl groups bonded silica packing material for sample separation, and a Pt-Rh catalytic column for the reduction of PAHQs to a corresponding fluorescent compound. The accuracy of the assay, as applied to airborne particulate sample extracts spiked with known amounts of PAHQs were 91 – 107%. The detection limits were 19 to 2000 fmol per injection (signal-to-noise ratio = 3), and the calibration range was from 1 to 100 pmol with excellent proportionality (R2≥0.9992) for four kinds of PAHQs: benz[a]anthracene-7,12-dione, fluoranthene-2,3-dione, pyrene-1,6-dione, and pyrene-1,8-dione. PAHQs in SOF of airborne particles collected in Kyoto, Japan were successfully measured using the established analytical method with simple sample-preparation steps: ultrasonic extraction in organic solvent and concentration under reduced pressure and/or a nitrogen stream. 続きを見る
42.

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鳥羽, 陽 ; 本間, 千春 ; 宇於崎, 和香 ; Chuesaard, Thanyarat ; 唐, 寧 ; 早川, 和一
出版情報: 分析化学 = Japan analyst.  63  pp.23-29,  2014-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44506
概要: A high-performance liquid chromatographic (HPLC) method with fluorescence detection was developed for the quantification of polycyclic aromatic hydrocarbons (PAHs) in cigarette mainstream and sidestream smoke particulates. Fifteen kinds of PAHs classified as priority pollutants by the US EPA were quantified with six perdeuterated PAHs as internal standards. The smoke filter samples obtained from 3 brands of cigarettes using standardized smoking conditions were extracted with dichloromethane, and then treated with tandem solid phase extraction cartridges (Silica and Neutral Alumina). The limits of detection ranged from 0.24 to 2.2 pg, and were more sensitive than those by GC-MS. The analytes were quantified by using the internal standards, and the developed method achieved sufficient reproducibility and accuracy. The PAH levels in mainstream and sidestream smoke from 3 cigarette brands were in the range of 0.2 – 305 ng cigarette−1 and 26.4 – 6160 ng cigarette−1, respectively. The total PAH content in sidestream smoke was more than 10 times higher compared with that of mainstream smoke. This method should be useful as an optional analytical method to quantify PAHs in cigarette smoke particulates. 続きを見る
43.

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今成, 登志男 ; 大久保, 登 ; 早川, 和一 ; 宮崎, 元一
出版情報: 分析化学 = Japan analyst.  28  pp.285-288,  1979-01-01.  日本分析化学会 = The Japan Society for Analytical Chemistry
URL: http://hdl.handle.net/2297/44504
概要: 生体試料中の金属を電気透析試料調製器によって陽イオンとして直接抽出する方法(A法)とEDTA-金属錯体として陰イオンとして抽出する方法(B法)について条件の検討を行った. A法の条件は泳動液0.05N酢酸,電流密度15mA/cm2,抽出時間 (20~40)分,B法の条件は泳動液0.05N水酸化アンモニウム-1m M EDTA,電流密度20mA/cm2,抽出時問(20~40)分であった.A法では鉄(III),銅(II)の回収率80%,亜鉛(II)の回収率は90%,一方B法については鉄(III),亜鉛(II)の回収率100%,銅(II)の回収率は95%であった.たん白質として牛血清アルブミン,電解質として塩化ナトリウムの共存の影響を調べた後,B法を血しょう中のアルブミン結合亜鉛の分析に応用した. The extraction of metals from biological materials by an electrodialytic sample preparator was studied. Two procedures are proposed in this method : one depends on the extraction of metals as cationic ions (Mode A) and the other depends on the extraction of metal-EDTA complexes as anionic ions (Mode B). The basic conditions for Mode A are : carrier solution; 0.05 N CH3COOH, current density; 15 mA/cm2, extraction time; (2040) min. The conditions for Mode B are : carrier solution; 0.05 N NH4OH-1 mM EDTA, current density; 20 mA/cm2 and extraction time; (2040)min. The recoveries of Fe(III), Cu(II) and Zn(II) in Mode A were 90, 80 and 90%, and in Mode B the recoveries were 100, 95 and 100% respectively. The effects of electrolytes and proteins on the extraction of metals were examined, and the application of Mode B for the determination of albumin bound zinc in human plasma was carried out as follows : the supernatant containing albumin bound zinc was obtained by polyethylene glycol treatment and subjected to electrodialysis for 40 min according to the conditions described in Mode B. Albumin bound zinc in the extract was determined by atomic absorption spectrometry (AAS). Total plasma zinc was measured according to direct dilution method by AAS and α2-macroglobulin bound zinc was obtained by the difference. 続きを見る
44.

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木津, 良一 ; 安藤, 京子 ; 早川, 和一
出版情報: 衛生化学 = Eisei kagaku.  44  pp.321-333,  1998-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44931
概要: The Russian tanker Nakhodka met a hull-broken accident in sailing in the Sea of Japan on January 2, 1997, releasing approximately 6200 kl of heavy oil into the Sea of Japan. The spilled oil was driven by the prevailing winds and water currents and polluted the coastline from the Shimane Prefecture through the Yamagata Prefecture. While much effort was made to remove the reached oil, many workers engaged in oil-removing complained of an eyeache, giddiness, a headache, etc. These symptoms were considered to be caused by volatile chemicals in the oil. Although the greater part of the oiled coastline was cleaned shortly after the oil pollution, there is concern that sands, rocks and sea water of the shore were still contaminated with chemicals included in the oil. Furthermore, some part has remained not to be treated. Extensive scientific studies were conducted to 1) evaluate the influence of volatile chemicals in the spilled oil on the health of oil-removing workers, 2) assess the impact of the spill on the ecosystem, 3) where and how long the contamination by the oil or chemicals persists in the environment. This paper reviews the activities and researches made after the Nakhodka oil spill accident. 続きを見る
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山本, 敦 ; 松永, 明信 ; 関口, 久義 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  31  pp.47-50,  1985-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44930
概要: Photometric ion chromatography is a novel method by using the photometer as a detector. A feature of this method is the use of light absorbing ion in the mobil phase, and the appearance of transparent sample ion in the effluent is detected by "trough"in the base line absorbance. We applied this technique by using a conventional HPLC system equipped with a commercially available ion exchange separation column to the determination of bromate in such foodstuffs as bread and kamaboko. Sample solution was prepared by aqueous extraction and mixed with acetone for removal of proteins. After evaporation of the organic solvent, the aqueous solution was dechlorinated by a DOWEX column (Ag-form), and then was subjected to chromatography. Samples of bread and kamaboko were spiked with 5.4 ppm and 8.4 ppm of bromate, respectively, and examined by the above method. The average recoveries were 88.3% in bread and 82.9% in kamaboko, and the coefficients of variation were 7.7% and 7.9%, respectively. The detection limit was 1 ppm. The above findings indicate that bromate can be detected by HPLC using conventional instrumentation, and the sensitivity of this system is comparable to conductimetric detection. 続きを見る
46.

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早川, 和一 ; 山本, 敦 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  40  pp.1-12,  1994-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44934
概要: Ion chromatography (IC), which was introduced in 1975, has become widely used for the sensitive and simultaneous determination of ions. In the early stage, the IC system consisted of two ion-exchange columns (separator and suppressor, respectively) and a conductivity detector. Although this combination is still the most popular, new forms of separation and suppression have been developed. On the other hand, an indirect photometric detection using a UV detector has become popular in IC and other detectors commonly used in HPLC also have been used. Each of them has specific advantages for different types of analyses. Thus, IC is now defined as a form of liquid chromatography of ions. This article reviews new developments of the different forms of IC and their applications, especially to environmental samples, foods, biological materials and drugs, from reports published since 1990. 続きを見る
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吉田, 育世 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  31  pp.317-323,  1985-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44928
概要: Simultaneous determination of carboxylic acids and inorganic anions was investigated by photometric ion chromatography w ith phthalate solution as an eluent. The retention time and the peak area of carboxylic acids changed remarkably with eluent pH. The optimum conditions at present were as follows : analytical column, OYOBUNKO ASA-4000 (4.6 mm i.d.×25 cm) ; eluent, 5×10-4 M disodium phthalate ; flow rate, 2 ml/min ; column temperature, 40°C ; detection wavelength, 240 nm ; injection volume, 100 μl. The detection limits for several carboxylic acids as 3 times noise were 0.05-0.07 mg/l in sample solution. Their calibration curves showed straight lines by the peak area method. The present method has an advantage to determine simultaneously not only carboxylic acids but also inorganic anions. Under the condition described above, both carboxylic acids and inorganic anions in several liquid foods were easily determined by direct injection of the sample prepared with only dilution. 続きを見る
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松永, 明信 ; 山本, 敦 ; 水上, 英一 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  34  pp.70-74,  1988-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44933
概要: A high-performance liquid chromatographic method using post column reaction system was established for the determination of polyphosphates (PP). Linear polyphosphates with the range of polymerization from 2 to 9 (P2-P9) could be separated on an anion exchange column, TSK GEL DEAE-5PW (Toyo Soda), with 0.01 M HNO3 containing NaNO3 as a mobile phase at flow rate of 1.0 ml/min, with a linear gradient in NaNO3 concentration at one hour intervals. PP were detected as the decrease of absorbance at 500 nm of ferric-sulfosalicylate complex by means of an on-line post column reaction at room temperature, with 0.5 mM FeCl3 containing 2.5 mM sulfosalicylic acid as reaction reagent at flow rate of 0.5 ml/min. The proposed method was applied to the analysis of 30 different commercial products of soft drinks. The pretreatment only necessary after mixing the sample with an equal volume of 0.01 M HNO3 was filtration through 0.45 μm pore size filter. P2-P6 (total 0.231 g/kg) and P2-P4 (0.070 g/kg) were found from 2 kinds of the samples, respectively. The determination limit was 0.02 m mol/kg for all of the PP. 続きを見る
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宮崎, 元一 ; 早川, 和一 ; 飯田, 寿恵 ; 藤井, ちず子
出版情報: 衛生化学 = Eisei kagaku.  28  pp.282-285,  1982-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44932
概要: A simple method by using a column packed with Amberlyst-15 resin was established to remove metal ions which affect on PO V and TBA tests for lipid peroxidation. A methanol solution (2 ml) of lipid containing metal ions was applied to the column (0.5 cm×5 cm), and eluted with methanol (6 ml). Metal ions such as Cu2+, Fe3+ and Mn2+ were retained on the column, whereas linoleic acid, linolenic acid and methyl linolenate were completely recovered in the eluate (8 ml). By testing the peroxidized lipid with POV and TBA methods, the recoveries of the lipid mixture after the procedure were more than 85% (POV) and more than 99% (TBA). This pretreatment by using Amberlyst-15 column is available for the peroxidation tests of lipid. 続きを見る
50.

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山本, 敦 ; 松永, 明信 ; 牧野, 正雄 ; 早川, 和一 ; 宮崎, 元一
出版情報: 衛生化学 = Eisei kagaku.  33  pp.174-178,  1987-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44937
概要: A method for the simultaneous determination of organic acids was investigated by photometric ion chromatography by using two different eluents. A 4.6 mm i.d.×25 cm stainless column packed with MCI GEL SCA 01 (Mitsubishi Chemical Ind., Ltd.) was used as a separator column. Sample was injected into this column previously equilibrated with 1 mM citraconic acid at pH 6.8. After elution of monobasic organic acids, the eluent was exchanged to a stronger one, 1 mM m-sulfobenzoic acid at pH 6.8. Dibasic organic acids were eluted before the column reequilibration with the secondary eluent. On the other hand, tribasic organic acids such as citric acid were eluted with the secondary eluent. To prevent the base line disorder due to the eluent exchange, the determination at 254 nm was performed. Because this wave length is an isosbestic point of the two eluents. Sour-taste agents in soft drinks could be analysed directly after dilution of samples. 続きを見る