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Hara, Akinori ; Furuichi, Kengo ; Koshino, Akihiko ; Yasuda, Haruka ; Tran, Trang Thi Thu ; Iwata, Yasunori ; Sakai, Norihiko ; Shimizu, Miho ; Kaneko, Shuichi ; Nakamura, Hiroyuki ; Wada, Takashi ; 原, 章規 ; 古市, 賢吾 ; 岩田, 恭宜 ; 坂井, 宣彦 ; 清水, 美保 ; 金子, 周一 ; 中村, 裕之 ; 和田, 隆志
概要:
金沢大学医薬保健研究域医学系<br />Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) in type
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2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diabetes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology<br />Embargo Period 12 months
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Konno, Tetsuo ; Hayashi, Kenshi ; Fujino, Noboru ; Nagata, Yoji ; Hodatsu, Akihiko ; Masuta, Eiichi ; Sakata, Kenji ; Nakamura, Hiroyuki ; Kawashiri, Masa-aki ; Yamagishi, Masakazu ; 今野, 哲雄 ; 林, 研至 ; 藤野, 陽 ; 永田, 庸二 ; 寳達, 明彦 ; 坂田, 憲治 ; 中村, 裕之 ; 川尻, 剛照 ; 山岸, 正和
概要:
金沢大学医薬保健研究域医学系<br />Background: Myocardial scarring can be assessed by cardiac magnetic resonance imaging with late gado
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linium enhancement and by endomyocardial biopsy. However, accuracy of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens remains unknown in hypertrophic cardiomyopathy. We investigated whether late gadolinium enhancement in the whole heart reflects microscopic myocardial scarring in the small biopsied specimens in hypertrophic cardiomyopathy. Methods and Results: Twenty-one consecutive patients with hypertrophic cardiomyopathy who were examined both by cardiac magnetic resonance imaging and by endomyocardial biopsy were retrospectively studied. The right interventricular septum was the target site for endomyocardial biopsy in all patients. Late gadolinium enhancement in the ventricular septum had an excellent sensitivity (100%) with a low specificity (40%) for predicting microscopic myocardial scarring in biopsied specimens. The sensitivity of late gadolinium enhancement in the whole heart remained 100% with a specificity of 27% for predicting microscopic myocardial scarring in biopsied specimens. Quantitative assessments of fibrosis revealed that the extent of late gadolinium enhancement in the whole heart was the only independent variable related to the microscopic collagen fraction in biopsied specimens (β = 0.59, 95% confident interval: 0.15-1.0, p = 0.012). Conclusions: Although there was a compromise in the specificity, the sensitivity of late gadolinium enhancement was excellent for prediction of microscopic myocardial scarring in hypertrophic cardiomyopathy. Moreover, the severity of late gadolinium enhancement was independently associated with the quantitative collagen fraction in biopsied specimens in hypertrophic cardiomyopathy. These findings indicate that late gadolinium enhancement can reflect both the presence and the extent of microscopic myocardial scarring in the small biopsied specimens in hypertrophic cardiomyopathy. © 2014 Konno et al.
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Higashi, Tomomi ; Ohkura, Noriyuki ; Fujimura, Masaki ; Nakai, Satoshi ; Honda, Yasushi ; Saijoh, Kiyofumi ; Hayakawa, Kazuichi ; Kobayashi, Fumihisa ; Michigami, Yoshimasa ; Olando, Anyenda Enoch ; Hitomi, Yoshiaki ; Nakamura, Hiroyuki ; 東, 朋美 ; 大倉, 徳幸 ; 藤村, 政樹 ; 西條, 淸史 ; 早川, 和一 ; 小林, 史彦 ; 道上, 義正 ; 人見, 嘉哲 ; 中村, 裕之
概要:
金沢大学医薬保健研究域医学系<br />Asian dust, known as kosa in Japanese, is a major public health concern. In this panel study, we eva
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luated the effects of exposure to kosa on daily cough occurrence. The study subjects were 86 patients being treated for asthma, cough variant asthma, or atopic cough in Kanazawa University Hospital from January 2011 to June 2011. Daily mean concentrations of kosa and spherical particles were obtained from light detection and ranging (LIDAR) measurements, and were categorized from Grade 1 (0 μg/m3) to 5 (over 100 μg/m3). The association between kosa and cough was analyzed by logistic regression with a generalized estimating equation. Kosa effects on cough were seen for all Grades with potential time lag effect. Particularly at Lag 0 (the day of exposure), a dose-response relationship was observed: the odds ratios for Grades 2, 3, 4, and 5 above the referent (Grade 1) were 1.111 (95% confidence interval (CI): 0.995-1.239), 1.171 (95% CI: 1.006-1.363), 1.357 (95% CI: 1.029-1.788), and 1.414 (95% CI: 0.983-2.036), respectively. Among the patients without asthma, the association was higher: the odds ratios for Grades 2, 3, 4 and 5 were 1.223 (95% CI: 0.999-1.497), 1.309 (95% CI: 0.987-1.737), 1.738 (95% CI: 1.029-2.935) and 2.403 (95% CI: 1.158-4.985), respectively. These associations remained after adjusting for the concentration of spherical particles or particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5). Our findings demonstrate that kosa is an environmental factor which induces cough in a dose-response relationship. © 2014 Elsevier B.V.<br />Embargo Period 12 months
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中村, 裕之
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研究紹介
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中村, 裕之
概要:
「学会開催報告」
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金沢大学十全医学会 ; 中村, 裕之 ; 河﨑, 洋志
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「オレキシンによる睡眠・覚醒調節の神経メカニズム」三枝理博 / 「臓器線維化機序の解明と治療法への展開」坂井宣彦 / 「細胞老化と炎症・がん：腸内細菌代謝物による肝がん促進作用」大谷直子 / 「腸内細菌叢の癌と炎症における役割」飯田宗穂 /
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「Metabolic Information Highways : 固体レベルでの糖・脂質・エネルギー代謝調節機構」片桐秀樹 / 「自律神経・ペプチド連関を基軸とするエネルギー代謝と免疫制御機構の研究」中里雅光 / 「視床下部インスリン作用による肝糖代謝調節」井上啓
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中村, 裕之
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中村, 裕之
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中村, 裕之 ; Nakamura, Hiroyuki
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金沢大学医薬保健研究域医学系<br />アレルギー疾患、特に難治性の気管支喘息と肥満の合併が、共通した食生活の問題から生じることが指摘されている。25年度にリクルートできた年齢3-5歳の児で3年間に喘息が消失した人の子4人と、存続した子5人
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、花粉症が存続した4人について、採取した糞便より、腸内菌種解析とメタゲノム解析を行った。その結果、3群間には、炭水化物摂取の差と、Enterobacteriaceaeなどの発現パターンの差が認められた。特に、喘息消失群と存続群ではBidfidobacteriuの発現パターンと体重増加の関係が認められることから、小児の喘息の消失には、炭水化物などの摂取を控えた体重増加の抑制が有効であると推測された。<br />The combination of allergic diseases such as asthma and obesity or overweight are considered to be produced by the eating habits. We have performed 3 years follow-up study on infants aged 3-5 years from 2013 and analyzed the strain of intestinal flora and metagenome. Four infants disappeared asthma and 5 did not, and 4 still showed pollinosis. We have observed the differences in the pattern of the expressions of enterobacteriaceae together with the intake of carbohydrates among the three groups. There was a correlation between the pattern of the expressions of the bidfidobacteriu and the increase in weight of infants after comparing between the infants with and without the disappearance of asthma. These results suggest that inhibiting unnecessary intake of carbohydrates, subsequently suppressing the excess of weight gain lead to the disappearance of asthma in infants.<br />研究課題/領域番号:25670295, 研究期間(年度):2013-04-01 - 2016-03-31
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中村, 裕之 ; Nakamura, Hiroyuki
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金沢大学医薬保健研究域医学系<br />アレルギー性疾患の原因については、胎児期あるいは小児期の前半に最も頻繁に感染するRespiratory syncytialウイルスなどのウイルスの関与がよく知られるようになったが、その病態の背景である
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感受性遺伝子との相互作用はよく知られていない。妊娠モデルマウスの児の脾臓細胞のIL4RA遺伝子におけるCpG部位のメチル化と感染の関係が出産直後において認められた。疫学研究では、臍帯血単核球のIL4RAにおけるCpG部位のメチル化がハウスダスト感作による喘息との関係において認められた。これらの結果から、出生直後の児において感染が成立するとともにアレルギー関連の遺伝子が発現していると考えられた。<br />The infection of virus such as respiratory syncytial virus is involved in pathogenesis of allergy during prenatal and postnatal infants, although the interaction between candidate genes and virus infection remains to be elucidated. We demonstrated hypomethylation of CpG islands produced by virus infection in IL4RA gene in splenic cells for postpartum infants from pregnant model mouse. Epidemiologic study showed the hypomethylation of CpG islands in in IL4RA gene in monocytes in cord blood of pregnant patients with asthma sensitized by house dust. These results suggest expression of IL4RA gene in just new born infants is produced by infection of RS virus.<br />研究課題/領域番号:23390160, 研究期間(年度):2011-04-01 - 2014-03-31
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