※一部利用できない機能があります
| 1.
論文 |
論文
|
Kobayashi, Mio ; Kakuda, Yuko ; Harada, Kenichi ; Sato, Yasunori ; Sasaki, Motoko ; Ikeda, Hiroko ; Terada, Mitsuhiro ; Mukai, Munenori ; Kaneko, Shuichi ; Nakanuma, Yasuni ; 小林, 水緒 ; 原田, 憲一 ; 佐藤, 保則 ; 佐々木, 素子 ; 池田, 博子 ; 金子, 周一 ; 中沼, 安二
概要:
金沢大学医薬保健研究域医学系<br />AIM: To investigate histological and immunohistochemical differences in hepatitis between autoimmune
…
hepatitis (AIH) and primary biliary cirrhosis (PBC) with AIH features. METHODS: Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined. The activity of periportal and lobular inflammation was scored 0 (none or minimal activity) to 4 (severe), and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3. The infiltration of mononuclear cells positive for CD20, CD38, CD3, CD4, and CD8 and positive for immunoglobulins (IgG, IgM, and IgA) at the periportal areas (interface hepatitis) and in the hepatic lobules (lobular hepatitis) were semiquantitatively scored in immunostained liver sections (score 0-6). Serum aspartate aminotransferase (AST), immunoglobulins, and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions. RESULTS: Lobular hepatitis, hepatitic rosette formation, and emperipolesis were more extensive and frequent in AIH than in PBC. CD3+, CD4+, and CD8+ cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC. The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC, but to a lesser degree in AIH. CD20+ cells were mainly found in the portal tracts and, occasionally, at the interface in both diseases. Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration, specifically CD38+ cells in PBC. No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH. While most AIH cases were IgG-predominant at the interface, PBC cases were divided into IgM-predominant, IgM/IgGequal, and IgG-predominant types, with the latter sharing several features with AIH. CONCLUSION: These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
続きを見る
|
||||
| 2.
論文 |
論文
|
Sato, Hirohide ; Sato, Yasunori ; Harada, Kenichi ; Sasaki, Motoko ; Hirano, Katsuyasu ; Nakanuma, Yasuni ; 佐藤, 保則 ; 原田, 憲一 ; 佐々木, 素子 ; 中沼, 安二
概要:
金沢大学医薬保健研究域医学系<br />A 77-year-old woman complained of epigastralgia, and a tumor (5 cm in diameter) of the gallbladder n
…
eck was detected by image analysis. Following cholecystectomy, the tumor was pathologically diagnosed as intraductal papillary neoplasm (IPN), gastric type, with associated invasive carcinoma. About 10 mo later, intraluminal multiple masses (3 foci, up to 1.8 cm) were noted in the extrahepatic bile duct, and the resected specimen showed that all tumors had similar gross and microscopic features as seen in gallbladder IPN without invasion, and they were synchronous multiple lesions. This case showed a papillary tumor of the gallbladder of gastric phenotype, and confirmed that the gallbladder is a target of IPN in addition to the bile ducts. © 2013 Baishideng. All rights reserved.
続きを見る
|
||||
| 3.
論文 |
論文
|
Sasaki, Motoko ; Araki, Ichiro ; Yasui, Toshiaki ; Kinoshita, Masaru ; Itatsu, Keita ; Nojima, Takayuki ; Nakanuma, Yasuni ; 佐々木, 素子 ; 野島, 孝之 ; 中沼, 安二
概要:
金沢大学医薬保健研究域医学系<br />We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old
…
man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type. © 2009 The WJG Press and Baishideng. All rights reserved.
続きを見る
|
||||
| 4.
論文 |
論文
|
佐々木, 素子 ; Sasaki, Motoko
概要:
金沢大学医学系研究科形態機能病理学<br />総説
|
||||
| 5.
論文 |
論文
|
Sasaki, Motoko ; Ikeda, Hiroko ; Nakanuma, Yasuni ; 佐々木, 素子 ; 中沼, 安二
概要:
金沢大学大学院医学系研究科がん細胞学<br />Mucin secreted by mucosal epithelial cells plays a role in the protection of the mucosal surface
…
and also is involved in pathological processes. So far, MUC1-4, 5AC, 5B, 6-8, 11-13 and 15-17 genes coding the backbone mucin core protein have been identified in humans. Their diverse physiological distribution and pathological alterations have been reported. We have studied the expression profiles of MUC genes in the intrahepatic biliary system in developmental, normal and diseased livers using immunohistochemistry and in situ hybridization. Fetal intrahepatic bile ducts and ductal plates frequently express MUC1, while intrahepatic large bile ducts after birth express mainly MUC3 mucin. In hepatolithiasis, MUC5AC (gastric foveolar epithelial type) and MUC6 (pyloric gland type) mucins are newly expressed in surface epithelial cells and proliferated peribiliary glands, respectively, and the expression of gel-forming mucin may play a role in lithogenesis. Most biliary epithelial dysplasias and cholangiocarcinomas associated with hepatolithiasis expressed MUC5AC, suggesting that intrahepatic bile ducts express the gastric foveolar phenotype during carcinogenesis. In addition, intestinal metaplasia, intraductal papillary tumor and mucinous carcinoma, characterized by MUC2 expression, are occasionally associated with hepatolithiasis in a CDX2 homeobox gene-dependent manner. These findings may suggest the presence of intestinal metaplasia-related carcinogenesis in the intrahepatic biliary system as in the stomach.
続きを見る
|
||||
| 6.
論文 |
論文
|
中沼, 安二 ; 原田, 憲一 ; 木村, 康 ; 佐藤, 保則 ; 佐々木, 素子 ; 池田, 博子
概要:
胆道癌の病理(肉眼像と組織像)を、『胆道癌取扱い規約』に従い、胆道癌を中心に解説した。胆道癌、とくに肝門部癌の分類と位置づけを述べた。現在、胆道癌の患者は世界的に増加傾向にあり、また外科的切除が唯一の根治的治療法であることから、手術に関連し
…
た病理情報が患者の予後の推定、治療法の開発、手術法の改善に重要である。また、胆道癌の予後良好群の設定とその解析、さらには胆道癌の前癌病変の解析も今後の課題と思われる。
続きを見る
|
||||
| 7.
論文 |
論文
|
佐々木, 素子 ; 中沼, 安二
概要:
肝内結石症などの慢性胆道疾患を背景に発生する胆道癌には, 顕微鏡下に捉えられる前癌性異型上皮病変の存在することが知られ, 胆嚢上皮デイスプラジアなどの名称で呼ばれてきた. 最近, この異型病変についてbiliary intraepithel
…
ial neoplasia (BilIN)の名称が普及しつつあり, WHOの消化器癌分類(2010)や胆道癌取り扱い規約第6版に掲載された. BilINは胆道癌の多段階発癌過程を反映する前癌病変・初期癌病変と考えられている. 病理組織学的には平坦型あるいは微小乳頭状の形態を示し, 異型度に応じてBilIN-1, BilIN-2, BilIN-3に分類される. BilIN分類を用いた病理診断については, 本稿で触れるいくつかの課題が残されている. しかし, BilINの臨床病理学的解析は, 胆道癌の発癌機序の解明, 早期診断への応用などへの貢献が期待される.
続きを見る
|
||||
| 8.
論文 |
論文
|
天谷, 奨 ; 平松, 活志 ; 片柳, 和義 ; 佐々木, 素子 ; 中沼, 安二
概要:
ヘリコバクター菌, 特にヘリコバクターピロリ(以下HP)は, 正常胃粘膜から慢性胃炎, 胃癌への進展に関係する病原因子として注目されている. しかしながら, これまでHPと胃以外の疾患との関連性に関してはほとんど知られていない. われわれは
…
最近, 肝内結石症の胆管粘膜で胃粘膜化生がみられることを明らかにした. 現在, 同部でのHP感染があるかどうかについて, 検討を行なっており, その成績の一部をここで述べる. HPと胆道系疾患との関係では文献的に, 胆嚢疾患での胆汁抵抗性ヘリコバクター種の関与が示唆されている. われわれの予備的な検討により, 肝内結石と胆管癌の肝内胆管粘膜でHPが免疫染色で高頻度で検出された. 最近の胆道系におけるヘリコバクター種の研究を総合すると, HPを含めたヘリコバクター種が胆道系疾患の発生, 進展に関連している可能性が考えられる. 今後, 各種の学際的方法により胆道系疾患の病態とヘリコバクター種感染の研究が必要であろう.
続きを見る
|
||||
| 9.
論文 |
論文
|
佐々木, 素子 ; 宮腰, 菜沙美 ; 佐藤, 保則 ; 中沼, 安二
|
||||
| 10.
論文 |
論文
|
千葉, 真由美 ; 佐々木, 素子 ; 北村, 星子 ; 中沼, 安二
|
