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石崎, 純子 ; 横川, 弘一 ; 中島, 恵美 ; 古田, 壽一 ; 越野, 好文 ; 関, 秀俊 ; 谷口, 昂 ; 長谷川, 光広 ; 山下, 純宏 ; 市村, 藤雄
概要:
金沢大学大学院自然科学研究科分子作用学<br />金沢大学医学部附属病院薬剤部<br />金沢大学大学院医学系研究科<br />A fully automated enzyme immunoassay system, Omni (BIO-T
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EK Co.) (ELISA system), using Markit-M Excegran and Markit-M Haloperidol (Dainippon Pharmaceutical Co.) was evaluated to determine the concentrations of zonisamide (ZNS) and haloperidol (HP) in human plasma. At first, the within-run (ZNS : n=8, HP : n=10) and the between-run (4 days) precisions of ZNS and HP were examined. The coefficient of the variations in both the within-run and the between-run previsions of HP were below 5.0 and 7.00/0, respectively. In contrast, the some values of ZNS were below 6.5 and 8.40/0, respectively. A good correlation was observed between this ELISA system and HPLC (r=0.917), which was used to determine the plasma ZNS concentration. In the case of HP, a good correlation was seen between this ELISA system and the manual ELISA method (r=0.978). This method was thus used to monitor the serum levels in patients receiving ZNS or HP therapy. The relationship was observed between the daily dose (mg/kg) and the plasma concentration of the trough level for ZNS and HP, respectively (r=0.750 p<0.001, r= 0.669 p<0.001). However, the ratio of the plasma concentration of ZNS and the daily dose increased significantly with aging.
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| 2.
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石崎, 純子 ; 横川, 弘一 ; 中島, 恵美 ; 永野, 耐造 ; 前田, 均 ; 市村, 藤雄
概要:
大学院自然科学研究科分子作用学<br />金沢大学医学部付属病院薬剤部<br />金沢大学大学院医学系研究科<br />Analysis of fasting effect on biperiden distribution in rats
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was examined. The plasma concentration at 24hr after i. v. injection of 3.2 mg/kg varied between 0.4 ng/ml (10-week-old fasted rats) and 1.4 ng/ml (10-week-old normal rats). The steady state distribution volume of biperiden in the fasted rats was smaller by 2/3 than that in the normal rats. The determined percentage of fat tissue per body weight reduced from 7.6 to 2.35 was caused by fasting. There was a good cerrelation between the steady state distribution volume of biperiden per lean mass body weight and the fat volume per lean mass body weight (r=0.989) in four different groups (10-week-old fasted 4-, 10-, and 50-week-old normal rats). The fat/plasma concentration ratios at 8hr after the i. v. injection varied between 380 (10-week-old normal rats) and 550 (10-week-old fasted rats), whereas the brain/plasma concentration ratios were identical to those at steady state among the two groups. The time courses of biperiden concentration in plasma, brain, and fat were simulated using a physiological pharmacokinetic model. There was reasonable agreement between the model predictions and the observed data, suggesting that the change in the fat volume is a dominant determinant of the distribution volume of biperiden in rats. Changes in fasted tissue and plasma concentrations are discussed in relation to the clinical usefulness of the blood level monitoring.
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中島, 恵美 ; 竹田, 正美 ; 石崎, 純子 ; 横川, 弘一 ; 松下, 良 ; 市村, 藤雄
概要:
金沢大学大学院自然科学研究科分子作用学<br />金沢大学医学部附属病院薬剤部<br />金沢大学大学院医学系研究科<br />Simple and sensitive methods are developed for microdete
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rmination of drugs acting on the central nervous system. The assay employs the partially purified synaptosomal membrane isolated from rat brain. In the assay, 3H-Quinuclidinyl benzylate competes with drugs for binding to the receptor. The detection limit for scopolamine was 20 ng/ml. This method was applied for the measurement of other drugs acting on the central nervous system. The values of IC 50 were lower than 0.1μg/ml in biperiden, trihexyphenidyl, levomepromazine, and promethazine. The method has been used to determine plasma levels in 9-week-old and 21-week-old rats after i.v. injection of 1 mg/kg scopolamine. The blood levels of scopolamine at each time after the administration are significantly different between 9-week-old and 21-week-old rats. The values of V_<dss> determined in 21-week-old rats were significantly increased as compared to the 9-week-old rats, whereas CL_<tot> were not changed.
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木戸, 日出喜 ; 倉田, 孝一 ; 木原, 義春 ; 水野, 義陽 ; 山口, 成良 ; 横川, 弘一 ; 市村, 藤雄
概要:
金沢大学医学部附属病院
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古川, 裕之 ; 平戸, 久美子 ; 古瀬, 裕 ; 旭, 満里子 ; 横川, 弘一 ; 島貫, 喜一 ; 田村, 裕喜男 ; 中野, 修 ; 打和, 寿子 ; 中島, 恵美 ; 市村, 藤雄
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金沢大学医学部付属病院薬剤部<br />education program hospital pharmacy practice pharmacy education
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木戸, 日出喜 ; 倉田, 孝一 ; 田端, 修 ; 岸谷, 和之 ; 山口, 成良 ; 横川, 弘一 ; 市村, 藤雄
概要:
金沢大学医学部附属病院
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倉田, 孝一 ; 木戸, 日出喜 ; 伊藤, 達彦 ; 小林, 克治 ; 山口, 成良 ; 松原, 六郎 ; 市村, 藤雄 ; 横川, 弘一 ; 山名, 月中
概要:
金沢大学医学部附属病院
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