多環芳香族炭化水素類の生体影響に対し輸送及び生体内代謝がどのように関与しているのか

フォーマット:

論文

責任表示:

戸次, 加奈江 ; 鳥羽, 陽 ; 唐, 寧 ; 亀田, 貴之 ; 滝上, 英孝 ; 鈴木, 剛 ; 早川, 和一

言語:

日本語

出版情報:

日本薬学会 = The Pharmaceutical Society of Japan, 2012-01-01

著者名:

戸次, 加奈江

鳥羽, 陽

唐, 寧

亀田, 貴之

滝上, 英孝

鈴木, 剛

早川, 和一

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掲載情報:

藥學雜誌 = Journal of the Pharmaceutical Society of Japan

ISSN:

0031-6903      

巻:

132

通号:

3

開始ページ:

325

終了ページ:

329

バージョン:

publisher

概要:

Polycyclic aromatic hydrocarbons (PAHs), some of which are carcinogenic/mutagenic, are generated by combustion of fossil fuels and also released through tanker or oilfield accident to cause a large scale environmental pollution. PAHs concentration in China is especially high in East Asia because of many kinds of generation sources such as coal heating systems, vehicles and factories without exhaust gas/particulate treatment systems. So, … the atmospheric pollution caused by PAHs in China has been seriously concerned from the view point of health effects. Like yellow sand and sulfur oxide, PAHs exhausted in China are also transported to Japan. Additionally, strongly mutagenic nitrated PAHs (NPAHs), estrogenic/antiestrogenic PAH hydroxides (PAHOHs) and reactive oxygen species-producing PAH quinones (PAHQs) are formed from PAHs by the chemical reaction during the transport. Furthermore these PAHOHs and PAHQs are produced by the metabolism in animal body. In the biological activities caused by the above PAH derivatives, the structure-activity relationship was observed. In this review, our recent results on the generation of PAH derivatives by atmospheric transport and metabolism are reported. Also, the existing condition of PAHs as atmospheric pollutants is considered. 続きを見る

URL:

http://hdl.handle.net/2297/44502