The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis

フォーマット:

論文

責任表示:

Ando, Hitoshi ; Takamura, Toshinari ; Matsuzawa-Nagata, Naoto ; Shima, Kosuke R. ; Nakamura, Seiji ; Kumazaki, Masafumi ; Kurita, Seiichiro ; Misu, Hirofumi ; Togawa, Naoyuki ; Fukushima, Tatsunobu ; Fujimura, Akio ; Kaneko, Shuichi

言語:

英語

出版情報:

Elsevier, 2009-03-13

著者名:

Ando, Hitoshi

Takamura, Toshinari

Matsuzawa-Nagata, Naoto

Shima, Kosuke R.

Nakamura, Seiji

Kumazaki, Masafumi

Kurita, Seiichiro

Misu, Hirofumi

Togawa, Naoyuki

Fukushima, Tatsunobu

Fujimura, Akio

Kaneko, Shuichi

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掲載情報:

Biochemical and Biophysical Research Communications

ISSN:

0006-291x      

巻:

380

通号:

3

開始ページ:

684

終了ページ:

688

バージョン:

author

概要:

金沢大学医薬保健研究域医学系<br />Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clo … ck remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH. © 2009 Elsevier Inc. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/17062