※一部利用できない機能があります
| 1.
論文 |
論文
|
Sakai, Kenji ; Asakawa, Miwako ; Takahashi, Ryoichi ; Ishida, Chiho ; Nakamura, Ritsuko ; Hamaguchi, Tsuyoshi ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito ; 坂井, 健二 ; 中村, 律子 ; 濵口, 毅 ; 小野, 賢二郎 ; 岩佐, 和夫 ; 山田, 正仁
概要:
金沢大学附属病院神経内科<br />Embargo Period 12 months
|
||||
| 2.
論文 |
論文
|
Yoshita, Mitsuhiro ; Ishida, Chiho ; Yanase, Daisuke ; Yamada, Masahito
概要:
金沢大学医薬保健研究域医学系<br />Myasthenic symptoms and the echocardiographic findings of dilated cardiomyopathy are very rare in pr
…
imary AL amyloidosis. We report a 59yearold man with dyspnea on effort and weakness after exercise. His electrocardiogram showed ischemic heart disease and echocardiography indicated dilated cardiomyopathy. Muscle biopsy revealed amyloidosis with deposits of lambda light chainderived amyloid within the vessel wall. Treatment with PGE1 resulted in improvement of the myasthenic symptoms. This patient indicates that myasthenic symptoms and dilated cardiomyopathy would be a unique syndrome associated with systemic AL amyloidosis involving mainly the small vessels, i.e., AL amyloid angiopathy, in the skeletal muscles and myocardium vessels.
続きを見る
|
||||
| 3.
論文 |
論文
|
Ishida, Chiho ; Sakajiri, Ken-ichi ; Yoshita, Mitsuhiro ; Joutel, Anne ; Cave-Riant, Florence ; Yamada, Masahito
概要:
金沢大学医薬保健研究域医学系<br />We report a 38-year-old Japanese woman who had cerebral autosomal dominant arteriopathy with subcort
…
ical infarcts and leukoencephalopathy (CADASIL) with a novel mutation (TGT to TAT) at nucleotide position 1241 (C388Y) in exon 7 of the Notch3 gene (NOTCH3). Immunostaining of a skin biopsy with a Notch3 monoclonal antibody is a beneficial method for the screening of CADASIL, particularly in the case of rare mutations outside the mutation hotspots in NOTCH3 as shown in this patient.
続きを見る
|
||||
| 4.
論文 |
論文
|
Shima, Keisuke ; Ishida, Chiho ; Okino, Soichi ; Kotani, Takeharu ; Higashi, Kotaro ; Yamada, Masahito
概要:
金沢大学医薬保健研究域医学系
|
||||
| 5.
論文 |
論文
|
Ishida, Chiho ; Furui, Eisuke ; Sakashita, Yasuo ; Yamada, Masahito
概要:
金沢大学医薬保健研究域医学系<br />We report a case of a 53-year-old man with Behçet’s disease (BD) and paradoxical stroke. This patien
…
t suddenly developed sensory aphasia, right oculomotor palsy, nystagmus, and left ataxic hemiparesis. MR images showed fresh embolic infarcts in the midbrain and the left parietotemporal lobe. He presented with uveitis, oral aphthous ulcers and genital ulcers. An electrocardiogram revealed no abnormalities, and a transesophageal echocardiogram disclosed a patent foramen ovale. Since venous involvement is common in BD, we suspected the presence of smaller thrombi probable in this patient. We conclude that embolic stroke is a notable complication of BD with right-to-left shunting.
続きを見る
|
||||
| 6.
論文 |
論文
|
Kato-Motozaki, Yuko ; Koma, Kiyonobu ; Takahashi, Kazuya ; Ishida, Chiho ; Ueda, Masami ; Kusunoki, Susumu ; Yamada, Masahito
概要:
金沢大学医薬保健研究域医学系<br />Polyethylene glycol-interferon ﾎｱ (PEG-IFNﾎｱ) has been used as the standard treatment for hepatitis
…
C virus (HCV) infection. There have been no previous reports of polyradiculoneuropathy with anti-ganglioside antibodies induced by PEG-IFNﾎｱ-2b. We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN ﾎｱ-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in his symptoms accompanied by a reduction in the antibody level. PEG-IFN ﾎｱ-2b may induce peripheral neuropathy mediated by anti-GA1 and anti-GM1 antibodies. © 2009 The Japanese Society of Internal Medicine.
続きを見る
|
||||
| 7.
論文 |
論文
|
Ishida, Chiho ; Fujii, Eisuke ; Sakashita, Yasuo ; Yamada, Masahito
概要:
We report a case of a 53-year-old man with Behçet's disease (BD) and paradoxical stroke. This patient suddenly developed
…
sensory aphasia, right oculomotor palsy, nystagmus, and left ataxic hemiparesis. MR images showed fresh embolic infarcts in the midbrain and the left parietotemporal lobe. He presented with uveitis, oral aphthous ulcers and genital ulcers. An electrocardiogram revealed no abnormalities, and a transesophageal echocardiogram disclosed a patent foramen ovale. Since venous involvement is common in BD, we suspected the presence of smaller thrombi probable in this patient. We conclude that embolic stroke is a notable complication of BD with right-to-left shunting.
続きを見る
|
||||
| 8.
論文 |
論文
|
Motozaki, Yuko ; Sugiyama, Yu ; Ishida, Chiho ; Komai, Kiyonobu ; Matsubara, Shiro ; Yamada, Masahito
概要:
金沢大学医学部附属病院神経内科<br />A family with familial amyloid polyneuropathy (FAP) due to a transthyretin (TTR) Leu58Arg mutation
…
was investigated clinicopathologically. The proband presented with sensorimotor-autonomic polyneuropathy and autopsy demonstrated massive amyloid deposition in the peripheral nerves and heart. However, the mother was characterized by carpal tunnel syndrome and ocular vitreous opacities. Thus, there was considerable phenotypic heterogeneity among family members despite the identical TTR genotype. © 2007 Elsevier B.V. All rights reserved.
続きを見る
|
||||
| 9.
論文 |
論文
|
Hirohata, Mie ; Yasukawa, Yoshihiro ; Ishida, Chiho ; Komai, Kiyonobu ; Yamada, Masahito
概要:
金沢大学医学部附属病院放射線部<br />We report a 50-year-old woman with primary Sjögren's syndrome (SjS) who initially showed forgetful
…
ness, and later developed disturbance of consciousness. In addition to aseptic meningoencephalitis revealed by cerebrospinal fluid examination and magnetic resonance imaging (MRI), the presence of serum anti-SS-A and anti-SS-B antibodies and inflammatory findings in lip biopsy indicated primary SjS. Fluid attenuated inversion recovery (FLAIR) of MRI revealed well defined small, high signal intensity areas in the cortex involving the subcortical white matter. Corticosteroid therapy resulted in rapid and nearly complete resolution of the cortical lesions with marked improvement of the clinical manifestations. Memory disturbance is a rare initial manifestation in meningoencephalitis associated with SjS. Our patient with SjS showed inflammatory cortical lesions on MRI, which were reversed by corticosteroid therapy. © 2005 Elsevier B.V. All rights reserved.
続きを見る
|
||||
| 10.
論文 |
論文
|
Sakai, Kenji ; Ikeda, Yoshihisa ; Ishida, Chiho ; Matsumoto, Yasuko ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito
概要:
Inclusion body myositis is a form of inflammatory myopathy. We identified 4 cases of inclusion body myositis showing gra
…
nuloma formation in muscle tissue and aimed to assess the features of this atypical form of inclusion body myositis. We retrospectively reviewed consecutive patients who satisfied European Neuromuscular Centre IBM Research Diagnostic Criteria 2011. Then, we assessed clinical profiles and pathological findings in patients with inclusion body myositis with granuloma and compared these findings with those of typical inclusion body myositis without granuloma. We identified 15 patients with inclusion body myositis. Four patients showed granuloma formation in muscle tissue in addition to typical pathological features of inclusion body myositis. Granulomas comprised a mixture of inflammatory cells, such as macrophages, epithelioid histiocytic cells, and lymphocytes. One patient was found to have mediastinal granulomatous lymphadenopathy; however, the evidence in other patients was insufficient for a diagnosis of systemic sarcoidosis. There were no significant differences between groups with and without granuloma regarding clinical manifestations, laboratory findings, response to immunomodulating therapies, or myopathological profiles. We established a new form of inclusion body myositis showing granuloma formation in muscle tissue. Inclusion body myositis and granuloma formation could have identical pathomechanisms concerning dysregulation of autophagy. © 2015 Elsevier B.V.<br />in Press / Embargo Period 12 months
続きを見る
|
