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| 1.
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須山, 知香 ; 吉川, 博章 ; Suyama, Chika ; Yoshikawa, Hiroaki
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| 2.
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Furukawa, Yutaka ; Yoshikawa, Hiroaki ; Iwasa, Kazuo ; Yamada, Masahito
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金沢大学保健管理センター<br />115<br />To clarify the long-term efficacy, safety and the cytokine network-modulating effects of tacr
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olimus in myasthenia gravis, medical records of 86 newly diagnosed consecutive patients and nine steroid-dependent patients were retrospectively reviewed, and peripheral blood mononuclear cells (PBMC) were cultured for the cytokine profile. Steroid reduction effects were observed by using tacrolimus, and no serious adverse effects were observed. The culture study showed reduced IL-12, IL-17, IFN-γ, GM-CSF, TNF-α and MIP-1β, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells. © 2008 Elsevier B.V. All rights reserved.
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| 3.
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Negami, Masako ; Maruta, Takahiro ; Takeda, Chie ; Adachi, Yumi ; Yoshikawa, Hiroaki
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Objective: The purpose of this study is to investigate the usefulness of sympathetic skin response (SSR) and heart rate variability (HRV) for the differential diagnosis of patients with dementia with Lewy bodies (DLB). Design:
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A diagnostic test study. Setting: Single centre in Japan. Participants: We examined 20 patients with probable Alzheimer's disease (AD) diagnosed with NINCDSADRDA criteria and 20 with probable DLB diagnosed with the criteria of the third international DLB workshop. Methods: For the SSR measurement, surface electrodes were used: the active recording electrode was placed on the palm of the hand and the reference electrode was placed on the dorsum of the same hand. SSR was induced by a median nerve electrical stimulation at an amplitude of 20 mA. For the HRV measurement, the A-A intervals were measured twice for 2 min with an interval of 5 min in a sitting position after a rest of 5 min. From the low-frequency power (LF; 0.02-0.15 Hz) and high-frequency power (HF; 0.15-0.50 Hz), the ratio of LF to HF power (LF/HF) was calculated using the maximal entropy method. Results: SSR and HRV could detect the abnormality of autonomic function in patients with DLB at sensitivities of 85% and 90%, respectively. On the other hand, SSR and HRV detected an abnormality of autonomic function in patients with AD at sensitivities of 15% and 25% (p<0.05). The combination of the SSR and the HRV (double-positive) indicated abnormal autonomic function was recorded in only 1 of 20 patients (5%) with AD. In contrast, this combination indicated autonomic abnormality in 15 of 20 patients with DLB by our criteria (75%). Conclusions: SSR and HRV can be applied to differentiate DLB from AD.
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| 4.
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Kobayashi, Shota ; Yokoyama, Shigeru ; Maruta, Takahiro ; Negami, Masako ; Muroyama, Akiko ; Mitsumoto, Yasuhide ; Iwasa, Kazuo ; Yamada, Masahito ; Yoshikawa, Hiroaki
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Autoantibody against nicotinic acetylcholine receptor (nAChR) α3 subunit has been implicated in the pathogenesis of para
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neoplastic neurological syndrome. To examine the effect of anti-α3 subunit autoantibody on cell-surface nAChRs, we established human embryonic kidney 293 cells stably co-expressing α3 and β4 subunits. Upon incubation with seropositive patient's serum, this cell line showed co-accumulation of patient's IgG and α3 subunits in the cytoplasm. These data support the hypothesis that anti-α3 subunit autoantibody induces internalization of cell-surface nAChRs and thereby impairs synaptic transmission. © 2012 Elsevier B.V. All rights reserved.
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| 5.
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Yoshikawa, Hiroaki ; Kiuchi, Takahiro ; Saida, Takahiko ; Takamori, Masaharu
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Objectives: To evaluate the ability of tacrolimus to reduce the corticosteroid dose in patients with myasthenia gravis (MG) and the drug's safety in a double-blind, placebo-controlled, parallel group study. Methods: Patients being
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treated with oral prednisolone at doses equivalent to 10-20 mg/day, and with stable symptoms, were randomised to tacrolimus or placebo in a 28-week double-blind study. The dose of corticosteroid was tapered with the procedures specified in the protocol. The primary efficacy endpoint was the mean daily prednisolone dose given in the last 12 weeks of the study. Results: Eighty patients received the study drug (40 patients in each group) and were included in the full analysis set. In the full analysis set, there was no significant difference in the primary efficacy endpoint between the two groups (p = 0.078). However, some secondary analyses suggested the steroid-sparing effect of tacrolimus. Tacrolimus was well tolerated, and no safety concerns were noted. Conclusions: This study suggests that tacrolimus has a potential advantage as a steroid-sparing agent in the treatment of MG patients. Copyright Article author (or their employer) 2011.
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Mabuchi, Kazunori ; Yoshikawa, Hiroaki ; Takamori, Masaharu ; Yokoji, Hidehiro ; Takahira, Masayuki
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金沢大学保健管理センター<br />A pseudo-Argyll Robertson pupil is a neurological sign indicating a normal near reflex but the absence
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of a light reflex (light-near dissociation), a lack of miosis, and pupil irregularity. It has been reported in patients with diabetes mellitus, multiple sclerosis, Wernicke's encephalopathy, sarcoidosis, tumours, and haemorrhage.1 Although the appearance of pseudo-Argyll Robertson pupil is very similar to Holmes-Adie pupil, the first is distinguishable from the second by the location of lesions and pharmacological response. The responsible lesion in pseudo-Argyll Robertson pupil is in the central region, whereas that of Holmes-Adie pupil is peripheral. Dilute pilocarpine constricts the pupils of patients with Holmes-Adie pupil, but it is not effective in patients with pseudo-Argyll Robertson pupil. We present a patient with spinocerebellar ataxia type 1 (SCA1) and her asymptomatic younger brother who both exhibited pseudo-Argyll Robertson pupil.
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Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
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金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth
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enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved.
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| 8.
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Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
概要:
金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth
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enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved.
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| 9.
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Edahiro, Shigeki ; Yoshikawa, Hiroaki ; Iwasa, Kazuo ; Hashii, Minako ; Yamada, Masahito
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金沢大学医薬保健研究域医学系<br />TE671 is a cell line obtained from the rhabdomyosarcoma cells. In the present study, we examined [Ca
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2+]i alteration induced by acetylcholine (ACh) in TE671/RD cells with the special attention to ryanodine receptor (RyR) and inositol 1,4,5-triphosphate receptor (IP3R). The change of [Ca2+]i was mediated by muscarinic type 3 (m3) AChR. Both phosphatidylinositol-specific phospholipase C blocker (U73122) and IP3R blocker (2-APB) inhibited ACh-induced [Ca2+]i elevation, suggesting that IP3 pathway is involved in [Ca2+]i alteration. Ryanodine and FK506 increased ACh-induced [Ca2+]i elevation, which was decreased by RyR blocker (ruthenium red). These results suggest that RyR and FK506 binding protein 12 kDa (FKBP12) complex was involved in [Ca2+]i change, and that TE671/RD cell line has a hybrid characteristic of smooth and skeletal muscles. Copyright © 2005 Biomedical Research Press.
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| 10.
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吉川, 弘明 ; Yoshikawa, Hiroaki
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金沢大学保健管理センター<br />学生相談室利用者（S群）と非利用者（H群）を比較した。S群は交感神経活動が高く、副交感神経活動が低かった。睡眠解析ではS群では寝返り回数が多く、覚醒時間が長かった。活動量解析ではS群で歩数合計、生活活動エ
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クササイズ合計が少なかった。SF-12はS群は身体機能、社会生活機能、日常役割機能、心の健康において点数が低かった。STAIはS群で不安が高かった。レジリエンス尺度はS群で低かった。AQはS群が高得点であった。WAISはIQに差はなかったが、言語理解がS群で高く作動記憶はH群で高かった。GAD65抗体はH群、S群ともに陰性であった。「香り」は、S群の特性をH群に近づけることがわかった。<br />We compared students who received psycho-counseling at the university counseling room (Group S) and those who did not (Group H). Group S had higher sympathetic activities and lower para-sympathetic activities. Sleep analyses revealed many rolling overs and long waking time after bed in S Group. SF-12 indicated lower points in physical functioning (PF), social functioning (SF), Role-Emotional (RE) and Mental Health (MH) of Group S. STAI indicated high anxiety in Group S. Resilience score was low in Group S. The score of Autism-Spectrum Quotient (AQ) was high in Group S. Though, there was no difference in IQ of WAIS, the language comprehension was good in Group S. the evaluation of working memory was excellent in Group H. The titer of anti-GAD65 antibody was negative in both Group H and S. The use of favorable fragrance improved the unfavorable features of Group S.<br />研究課題/領域番号:15H03084, 研究期間(年度):2015-04-01 - 2018-03-31
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