1.

論文
論文
1. Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells
Kobayashi, Shota ; Yokoyama, Shigeru ; Maruta, Takahiro ; Negami, Masako ; Muroyama, Akiko ; Mitsumoto, Yasuhide ; Iwasa, Kazuo ; Yamada, Masahito ; Yoshikawa, Hiroaki
出版情報: Journal of Neuroimmunology.  257  pp.102-106,  2013-04-15.  Elsevier B.V.
URL: http://hdl.handle.net/2297/33430
概要: Autoantibody against nicotinic acetylcholine receptor (nAChR) α3 subunit has been implicated in the pathogenesis of para … neoplastic neurological syndrome. To examine the effect of anti-α3 subunit autoantibody on cell-surface nAChRs, we established human embryonic kidney 293 cells stably co-expressing α3 and β4 subunits. Upon incubation with seropositive patient's serum, this cell line showed co-accumulation of patient's IgG and α3 subunits in the cytoplasm. These data support the hypothesis that anti-α3 subunit autoantibody induces internalization of cell-surface nAChRs and thereby impairs synaptic transmission. © 2012 Elsevier B.V. All rights reserved. 続きを見る
2.

論文
論文
2. Autoantibody to dihydropyridine receptor in myasthenia gravis
Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
出版情報: Journal of Neuroimmunology.  208  pp.125-129,  2009-03-31.  Elsevier
URL: http://hdl.handle.net/2297/16736
概要: 金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth … enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved. 続きを見る
3.

論文
論文
3. Autoantibody to dihydropyridine receptor in myasthenia gravis
Maruta, Takahiro ; Yoshikawa, Hiroaki ; Fukasawa, Shuichi ; Umeshita, Sho ; Inaoka, Yoshihiro ; Edahiro, Shigeki ; Kado, Hirotsugu ; Motozaki, Yuko ; Iwasa, Kazuo ; Yamada, Masahito
出版情報: Journal of Neuroimmunology.  208  pp.125-129,  2009-03-31.  Elsevier BV
URL: http://hdl.handle.net/2297/17330
概要: 金沢大学保健管理センター<br />To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasth … enia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodies showed no significant correlation with autoantibodies to acetylcholine nor ryanodine receptors. The DHPR antibody is another marker for thymoma in MG, and it might have some role in clinical symptoms related to E-C coupling. © 2009 Elsevier B.V. All rights reserved. 続きを見る