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Hormone levels in the saliva of lactating Vietnamese mothers in a dioxin hot-spot area

フォーマット:
論文
責任表示:
Dang, Duc Nhu ; Kido, Teruhiko ; Naganuma, Rie ; Saito, Kae ; Suzuki, Hiroyuki ; Kuroda, Naoko ; Honma, Seijiro ; Pham, The Tai ; Maruzeni, Shoko ; Nishijo, Muneko ; Nakagawa, Hideaki ; Nguyen, Ngoc Hung ; Le, Thi Hong Thom
言語:
英語
出版情報:
金沢大学つるま保健学会 = the Tsuruma Health Science Society, Kanazawa University, 2009-12-25
著者名:
Dang, Duc Nhu
Kido, Teruhiko
Naganuma, Rie
Saito, Kae
Suzuki, Hiroyuki
Kuroda, Naoko
Honma, Seijiro
Pham, The Tai
Maruzeni, Shoko
Nishijo, Muneko
Nakagawa, Hideaki
Nguyen, Ngoc Hung
Le, Thi Hong Thom
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掲載情報:
金沢大学つるま保健学会誌 = Journal of the Tsuruma Health Science Society Kanazawa University
ISSN:
1346-8502  CiNii Research  Webcat Plus  JAIRO
巻:
33
通号:
2
開始ページ:
59
終了ページ:
66
バージョン:
publisher
概要:
【目的】アメリカ軍は1961年から1971年の間に8000万リットル以上の枯葉剤を南ベトナムに撒布した。この研究の目的はベトナムの枯葉剤高濃度汚染地域(Binh Dinh省Phu Cat県)と非汚染地域(Ha Nam省Kim Bang県)において枯葉剤(オレンジ剤)の暴露と人体への健康影響との関連を検討することである。【方法】2つの地域において疫学的調査を実施した。対象者は授乳中で生後4週から16週の乳児を持つ20-30歳の母親とし、汚染地域では58名、非汚染地域では53名で あった。疾患の危険因子等に関する情報は母親への面接調査から得た。母乳をすべての対象者から採取したが、唾液を採取したのは汚染地域41名、非汚染地域19名であった。母親と子どもの身体計測を行い2地域間で比較を行った。【結果と考察】汚染地域における乳児の体重と胸囲は有意に非汚染地域よりも小さいが、年齢(週数)も汚染地域の方が有意に低かった。汚染地域における母親とその家族の現病歴は非汚染地域よりも有意に多かった。母親の視力は両眼とも2地域間で有意差は認められなかった。汚染地域と非汚染地域双方の母親の唾液中のコルチゾン値は、母乳中のコルチゾン値と高い相関を示した。汚染地域と非汚染地域間で唾液中のホルモン値には有意差は認められなかった。Objective : Between 1961 and 1971 the US military used over 80 million litres of herbicides in southern Vietnam. This study aims to assess hormone levels in the saliva of lactating Vietnamese mothers and human health effects in a dioxin hot spot (Phu Cat district, Binh Dinh province) and a non-exposed (Kim Bang district, Ha Nam province) area in Vietnam. Materials and Methods : An epidemiological study was carried out in both areas. The subjects were 58 lactating females in the hot spot area and 53 lactating females in the non-exposed area. All were aged between 20 and 30 years with infants aged between 4 and 16 weeks. Information about disease risk factors was obtained through interviews with mothers. Breastmilk samples were taken from all subjects, whereas saliva samples were obtained from 41 mothers in the hot spot area and 19 in the non-exposed area. Body measurements for both mothers and their infants were compared between the two areas. Result and Discussion : The weight and chest circumference of infants in the hot spot area were significantly lower than those in the non-exposed area, whereas age (weeks) is also significantly younger in hot spot area than non-exposed area. Present maternal and family diseases in the hot spot area were significantly higher than those in the non-exposed area. Maternal eyesight in both eyes did not differ significantly between the two areas. The cortisone levels in saliva have been found to be closely related to those in breast milk samples of both mothers in hot spot and non-exposed areas. No significant difference was found between salivary hormone levels of mothers in the hot spot and non-exposed areas. 続きを見る
URL:
http://hdl.handle.net/2297/20310
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