Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulb

フォーマット:

論文

責任表示:

Kinoshita, Yayoi ; Shiga, Hideaki ; Washiyama, Kohshin ; Ogawa, Daisuke ; Amano, Ryohei ; Ito, Makoto ; Tsukatani, Toshiaki ; Furukawa, Mitsuru ; Miwa, Takaki

言語:

英語

出版情報:

Oxford University Press, 2008-01-01

著者名:

Kinoshita, Yayoi

Shiga, Hideaki

Washiyama, Kohshin

Ogawa, Daisuke

Amano, Ryohei

Ito, Makoto

Tsukatani, Toshiaki

Furukawa, Mitsuru

Miwa, Takaki

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掲載情報:

Chemical Senses

ISSN:

0379-864x      

巻:

33

通号:

1

開始ページ:

73

終了ページ:

78

バージョン:

author

概要:

金沢大学医学部附属病院耳鼻咽喉科<br />Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration. In this study, we show that an alkali metal ion, thallium is transported in the ol … factory nerve fibers to the olfactory bulb in mice. The olfactory nerve fibers of mice were transected on both sides of the body under anesthesia. A double tracer solution (thallium-201, 201Tl; manganese-54, 54Mn) was administered into the nasal cavity the following day. Radioactivity in the olfactory bulb and nasal turbinate was analyzed with gamma spectrometry. Auto radiographic images were obtained from coronal slices of frozen heads of mice administered with 201Tl or 54Mn. The transection of the olfactory nerve fibers was confirmed with a neuronal tracer. The transport of intranasal administered 201Tl/54Mn to the olfactory bulb was significantly reduced by the transection of olfactory nerve fibers. The olfactory nerve transection also significantly inhibited the accumulation of fluoro-ruby in the olfactory bulb. Findings indicate that thallium is transported by the olfactory nerve fibers to the olfactory bulb in mice. The assessment of thallium transport following head injury may provide a new diagnostic method for the evaluation of olfactory nerve injury. © The Author 2007. Published by Oxford University Press. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/9540