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論文

論文
Nomura, Akitaka ; Mizukami, Yuji ; Matsubara, Fujitsugu ; Shimizu, Junzo ; Oda, Makoto ; Watanabe, Yoh ; Kamimura, Ryoichi ; Takashima, Tsutomu
出版情報: Internal medicine (Tokyo, Japan).  31  pp.756-765,  1992-06-01.  日本内科学会 = Japanese Society of Internal Medicine
URL: http://hdl.handle.net/2297/16779
概要: 金沢大学医薬保健研究域保健学系<br />Seven patients (mean age, 50.7 +/- 20.4 years; range 21-77) with plasma cell granuloma (PCG) of the lung are reported. Cough and sputum were the most common presenting symptoms, followed by fever. Elevated erythrocyte sedimentation rate and serum C-reactive protein levels were found in all patients tested. Radiologically, five cases presented as solitary, well-circumscribed masses and two as ill-defined, pneumonia-like densities. One showed focal calcification. No predilection of occurrence was observed in either lobe of the lung. Histologically, the lesions consisted of a proliferation of mature plasma cells and reticulo-endothelial cells supported by a stroma of granulation tissue, with varying degrees of myxoid change or collagenization. Angioinvasion within the lesion was observed in 4 of the 7 cases. Immunohistochemical staining revealed the IgG-predominant polyclonal nature of the plasma cells, indicating a reactive inflammatory process rather than a neoplastic one. Electron microscopy confirmed the benign nature of the plasma cells with fibroblast and myofibroblast proliferation admixed with that of other inflammatory cells. 続きを見る
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論文

論文
Nomura, Akitaka ; Mizukami, Yuji ; Shimizu, Junji ; Oda, Makoto ; Watanabe, Yoh ; Kamimura, Ryoichi ; Takashima, Tsutomu ; Kitagawa, Masanobu
出版情報: Internal medicine (Tokyo, Japan).  31  pp.1396-1400,  1992-12-01.  日本内科学会 = Japanese Society of Internal Medicine
URL: http://hdl.handle.net/2297/16781
概要: 金沢大学医薬保健研究域保健学系<br />A case with primary plasmacytoma of the lung is described. The patient, a 55-year-old Japanese fema le, who simultaneously had a pulmonary plasmacytoma and bladder carcinoma. The bladder tumor was treated with transurethral resection. Pathologically, the bladder tumor was a non-invasive, papillary transitional cell carcinoma, grade II. The lung tumor was located in the right upper lobe and upper lobectomy was performed. The tumor measured 2.8 x 2.7 x 2.0 cm and had a white-yellowish cut surface. Histologic, electron microscopic and immunohistochemical examinations of the lung tumor revealed monoclonal proliferation of plasma cells (IgA, lambda light chain). There was no evidence of multiple myeloma. 続きを見る
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論文

論文
Nomura, Akitaka ; Mizukami, Yuji ; Hirone, Takae ; Ohtake, Shigeki ; Yoshida, Takashi ; Nakamura, Shinobu ; Matsuda, Tamotsu ; Naito, Katsusuke ; Tachibana, Osamu ; Muramoto, Hiroaki
出版情報: Internal medicine (Tokyo, Japan).  32  pp.139-144,  1993-02-01.  日本内科学会 = Japanese Society of Internal Medicine
URL: http://hdl.handle.net/2297/16777
概要: 金沢大学医薬保健研究域保健学系<br />We report a case of unusual B-cell malignant lymphoma of the kidney and mediastinum. Renal biopsy s howed prominent myxoid changes and sarcomatous features, leading to considerable difficulty in histologic diagnosis on routinely stained histologic sections. However, immunohistochemical staining for lymphocyte markers led to the final histologic diagnosis of B-cell malignant lymphoma. Although myxoid change is not generally found in malignant lymphoma, malignant lymphoma should not be excluded from consideration when one encounters a small round cell sarcoma with myxoid stroma, especially in extranodal soft tissue tumors. 続きを見る