Co-expression of NGF and Its High-affinity Receptor TrkA in the Rat Carotid Body Chief Cells

フォーマット:

論文

責任表示:

山本, 美由紀 ; 井関, 尚一

言語:

英語

出版情報:

日本組織細胞化学会, 2003-01-01

著者名:

• 山本, 美由紀
• 井関, 尚一

掲載情報:

Acta Histochemica et Cytochemica

ISSN:

0044-5991      

巻:

36

通号:

4

開始ページ:

377

終了ページ:

383

バージョン:

publisher

概要:

金沢大学大学院医学系研究科がん細胞学<br />The expression and localization of NGF and its high-affinity receptor, TrkA, in the rat carotid body was investigated by use of in situ hybridization and immunohistochemistry, respectively. The immunoreactivity … for TrkA was detected in most of chief cells and sustentacular cells, as well as in some nerve axons and perineurial cells, but not in Schwann cells. In electron microscopy, the immunoreactivity was localized to the cytoplasm. The mRNA for NGF was localized to most of chief cells and possibly also to sustentacular cells. These results demonstrated that carotid body chief cells, having the neural crest origin, produce both NGF and TrkA, implying a paracrine-autocrine role of NGF in the carotid body. 続きを見る

URL:

http://hdl.handle.net/2297/6776