※一部利用できない機能があります
Comparison of eplerenone and spironolactone for the treatment of primary aldosteronism
- フォーマット:
- 論文
- 責任表示:
- Karashima, Shigehiro ; Yoneda, Takashi ; Kometani, Mitsuhiro ; Ohe, Masashi ; Mori, Shunsuke ; Sawamura, Toshitaka ; Furukawa, Kenji ; Seta, Takashi ; Yamagishi, Masakazu ; Takeda, Yoshiyu
- 言語:
- 英語
- 出版情報:
- 日本高血圧学会 = Japanese Society of Hypertension, 2016-03-01
- 著者名:
Karashima, Shigehiro Yoneda, Takashi Kometani, Mitsuhiro Ohe, Masashi Mori, Shunsuke Sawamura, Toshitaka Furukawa, Kenji Seta, Takashi Yamagishi, Masakazu Takeda, Yoshiyu - 掲載情報:
- Hypertension Research
- ISSN:
- 0916-9636
- 巻:
- 39
- 通号:
- 3
- 開始ページ:
- 133
- 終了ページ:
- 137
- バージョン:
- author
- 概要:
- The mineralocorticoid receptor (MR) is expressed in the kidneys and in adipose tissue, and primary aldosteronism (PA) is associated with metabolic syndrome. This study assessed the effects of MR blockade by eplerenone (EPL) and spironolactone (SPL) on blood pressure (BP) and metabolic factors in patients with PA. Fifty-four patients with PA were treated with one of two MRAs, EPL (25-100 mg daily, n=27) or SPL (12.5-100 mg daily, n=27) for 12 months. Visceral … (VAT) and subcutaneous adipose tissue were quantified using CT and FatScan imaging analysis software. Body mass index, homeostasis model assessment-insulin resistance (HOMA-IR), serum creatinine, potassium and lipids, urinary albumin excretion (UAE) and plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were measured before and after treatment. EPL and SPL decreased BP and increased serum potassium levels to similar degrees. PAC and PRA did not differ between the two groups. Although treatment with the MRAs did not change HOMA-IR or serum lipids, they significantly decreased UAE and VAT (P<0.05). These results suggest that EPL and SPL are effective and safe for the treatment of PA. The long-term metabolic and renal effects of these MRAs should be further investigated. © 2016 The Japanese Society of Hypertension. All rights reserved.<br />Embargo Period 6 months 続きを見る
- URL:
- http://hdl.handle.net/2297/44875
類似資料:
Japanese Society of Internal Medicine = 日本内科学会 | |
Wolters Kluwer Health / Lippincott Williams & Wilkins |
Hindawi Publishing Corporation |
Baishideng Publishing Group | |
Nature Publishing Group |
Hindawi Publishing Corporation |
5
論文
Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index
Hindawi Publishing Corporation | |
日本老年医学会 = The Japan Geriatrics Society |
Japanese Society of Internal Medicine = 日本内科学会 |