Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity

フォーマット:

論文

責任表示:

Oshima, Masanobu ; Suzki, Hiromi ; Guo, Xiaoying ; Oshima, Hiroko

言語:

英語

出版情報:

日本実験動物学会 = Japanese Association for Laboratory Animal Science, 2007-01-01

著者名:

• Oshima, Masanobu
• Suzki, Hiromi
• Guo, Xiaoying
• Oshima, Hiroko

掲載情報:

Experimental Animals

ISSN:

1341-1357      

巻:

56

通号:

4

開始ページ:

309

終了ページ:

313

バージョン:

publisher

概要:

We have previously demonstrated that short-term exposure to hypergravity at 2G for 4 h induces expression of cyclooxygenase-2 (COX-2) in the mouse heart. Moreover, expression of vascular endothelial growth factor (VEGF) is also induced in the heart in a COX-2-dependent manner. Here, we demonstrate that long-term exposure of mice to 2G for 24 h resulted in a significant increase of serum VEGF level, although expression of COX-2 and VEGF in the heart decreased … to the 1G-control level. Moreover, increase of serum VEGF was not suppressed by treatment with COX-2 inhibitor, indicating that VEGF was induced in a COX-2-independent manner. These results suggest that gravitational force contributes to maintenance of the serum VEGF level. 続きを見る

URL:

http://hdl.handle.net/2297/28450